Patents by Inventor Ashok K. Tehim

Ashok K. Tehim has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Optically pure stereogenically labile 4-substituted-2-hydroxytetronic acids and pharmaceutical use
    Patent number: 5298526
    Abstract: The present invention relates to a method for synthesis of optically pure stereogenically labile 4-substituted-2-hydroxytetronic acids from an asymmetric .alpha.-hydroxy ester. The chiron approach of the present invention utilizes a non-nucleophilic lithium amide base under kinetically controlled Claisen conditions to produce a 4-substituted-2-pheylmethoxy precursor to the 4-substituted-2-hydroxy tetronic acid. The invention further relates to the use of such optically pure compounds as potent inhibitors of platelet aggregation by working at the level of cyclooxygenase. The invention further relates to the pharmaceutical use of such compounds in the treatment of coronary artery diseases, especially in the treatment and/or prevention of atherosclerosis.
    Type: Grant
    Filed: March 6, 1992
    Date of Patent: March 29, 1994
    Assignee: The Ohio State University Research Foundation
    Inventors: Donald T. Witiak, Ashok K. Tehim
  • Efficient synthesis for optically pure stereogenically labile 4-substituted-2-hydroxytetronic acids
    Patent number: 5095126
    Abstract: The present invention relates to a method for synthesis of optically pure stereogenically labile 4-substituted-2-hydroxytetronic acids from an asymmetric .alpha.-hydroxy ester. The chiron approach of the present invention utilizes a non-nucleophilic lithium amide base under kinetically controlled Clasien conditions to produce a 4-substituted-2-pheylmethoxy precursor to the 4-substituted-2-hydroxy tetronic acid. The invention further relates to the use of such optically pure compounds as potent inhibitors of platelet aggregation by working at the level of cyclooxygenase. The invention further relates to the pharmaceutical use of such compounds in the treatment of coronary artery diseases, especially in the treatment and/or prevention of atherosclerosis.
    Type: Grant
    Filed: January 12, 1990
    Date of Patent: March 10, 1992
    Assignee: Ohio State University Research Foundation
    Inventors: Donald T. Witiak, Ashok K. Tehim