Patents by Inventor ASHOK KUMAR NUVULA

ASHOK KUMAR NUVULA has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Chromatographic process for producing high purity fibrinogen and thrombin
    Patent number: 9932388
    Abstract: The present invention relates to a chromatographic process for obtaining purified fibrinogen and thrombin from human plasma. The purified fibrinogen and thrombin preparations contain plasminogen in amounts less than 1 ug/mL. The low levels of plasminogen eliminates use of a proteolytic inhibitor, such as aprotinin in fibrin sealant kits which are used for human therapeutic applications.
    Type: Grant
    Filed: October 14, 2015
    Date of Patent: April 3, 2018
    Assignee: Hemarus Therapeutics Limited
    Inventors: Ashok Kumar Nuvula, Mitali Samaddar, Neelima Vadde, Zinia Chakraborty, Swapna Sagar Duggineni, Uma Devi Komath
  • Process for increased yield of immunoglobulin from human plasma
    Patent number: 9556253
    Abstract: The present invention discloses a preparation method for large scale production of human immunoglobulins (IgG) with high yields by an improved all-chromatography process scheme that eliminates ethanol precipitation. The process of extracting immunoglobulins is such that the other therapeutic proteins in plasma are left unaffected and are available for extraction separately from the same plasma sample. The yields obtained are in the range of 7 to 8 grams of IgG per liter of plasma. The high yielding process scheme of the present invention comprises of chromatographic steps and viral inactivation or removal steps to obtain a purified immunoglobulin protein that complies with pharmacopoeial limits and is suitable for therapeutic administration (normal intravenous immunoglobulin—IVIG).
    Type: Grant
    Filed: December 19, 2014
    Date of Patent: January 31, 2017
    Assignee: HEMARUS THERAPEUTICS LIMITED
    Inventors: Ashok Kumar Nuvula, Zinia Chakraborty, Vvs Sailesh Bavirisetti, Thirupati Reddy Katkuri, Uma Devi Komath
  • PROCESS FOR INCREASED YIELD OF IMMUNOGLOBULIN FROM HUMAN PLASMA
    Publication number: 20160152690
    Abstract: The present invention discloses a preparation method for large scale production of human immunoglobulins (IgG) with high yields by an improved all-chromatography process scheme that eliminates ethanol precipitation. The process of extracting immunoglobulins is such that the other therapeutic proteins in plasma are left unaffected and are available for extraction separately from the same plasma sample. The yields obtained are in the range of 7 to 8 grams of IgG per liter of plasma. The high yielding process scheme of the present invention comprises of chromatographic steps and viral inactivation or removal steps to obtain a purified immunoglobulin protein that complies with pharmacopoeial limits and is suitable for therapeutic administration (normal intravenous immunoglobulin—IVIG).
    Type: Application
    Filed: December 19, 2014
    Publication date: June 2, 2016
    Applicant: HEMARUS THERAPEUTICS LIMITED
    Inventors: ASHOK KUMAR NUVULA, ZINIA CHAKRABORTY, VVS SAILESH BAVIRISETTI, THIRUPATI REDDY KATKURI, UMA DEVI KOMATH
  • PROCESS FOR PRODUCING HIGH PURITY FIBRINOGEN AND THROMBIN FOR FIBRIN SEALANT
    Publication number: 20160137719
    Abstract: The present invention relates to a fibrin sealant kit comprising purified fibrinogen and thrombin. The invention particularly relates to an improved chromatographic process for the purification of thrombin and fibrinogen components devoid of any significant plasminogen and other impurities. The absence of plasminogen facilitates the exclusion of a proteolytic inhibitor (aprotinin) from among the kit components.
    Type: Application
    Filed: October 14, 2015
    Publication date: May 19, 2016
    Inventors: ASHOK KUMAR NUVULA, MITALI SAMADDAR, NEELIMA VADDE, ZINIA CHAKRABORTY, SWAPNA SAGAR DUGGINENI, UMA DEVI KOMATH