Patents by Inventor Ashok Malavalli

Ashok Malavalli has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Polyalkylene oxide valerate hemoglobin conjugates
    Patent number: 10821158
    Abstract: The present invention relates generally to polyethylene glycol (PEG) conjugated hemoglobins made by conjugation of succinimidyl-valerate activated polyethylene glycol to primary amines and N-terminal valines of the hemoglobin.
    Type: Grant
    Filed: March 17, 2014
    Date of Patent: November 3, 2020
    Inventors: Ashok Malavalli, Gnel Mkrtchyan, Kim D. Vandegriff
  • Methods for preparing PEG-hemoglobin conjugates using reduced reactant ratios
    Patent number: 9493616
    Abstract: The present invention relates generally to methods for preparing polyethylene glycol (“PEG”) conjugated hemoglobin (“Hb”) using reduced reactant ratios. More specifically, the present invention relates to methods for preparing PEG conjugated Hb (“PEG-Hb”) with enhanced yield and purity.
    Type: Grant
    Filed: February 23, 2011
    Date of Patent: November 15, 2016
    Assignee: Sangart, Inc.
    Inventors: Ashok Malavalli, Kim D. Vandegriff
  • POLYALKYLENE OXIDE VALERATE HEMOGLOBIN CONJUGATES
    Publication number: 20160022783
    Abstract: The present invention relates generally to polyethylene glycol (PEG) conjugated hemoglobins made by conjugation of succinimidyl-valerate activated polyethylene glycol to primary amines and N-terminal valines of the hemoglobin.
    Type: Application
    Filed: March 17, 2014
    Publication date: January 28, 2016
    Inventors: Ashok Malavalli, Gnel Mkrtchyan, Kim D. Vandegriff
  • MalPEG-Hb conjugate-containing compositions for delivering carbon monoxide (CO) to cells
    Patent number: 9138463
    Abstract: The present invention relates to compositions for delivering carbon monoxide (CO) to cells using heme proteins as carriers. In one embodiment, the present invention relates to the use of MalPEG surface modified hemoglobin to deliver CO to cells.
    Type: Grant
    Filed: October 19, 2011
    Date of Patent: September 22, 2015
    Inventors: Robert M. Winslow, Nancy Jo Winslow, Kim Vandegriff, Ashok Malavalli
  • SUCCINIMIDE-ACTIVATED NITROXYL COMPOUNDS AND METHODS FOR THE USE THEREOF FOR NITROXYLATION OF PROTEINS
    Publication number: 20150094267
    Abstract: The present invention relates to succinimide-activated nitroxyl compounds and methods for the synthesis of such compounds. The present invention also relates to the use of succinimide-activated nitroxyl compounds to prepare nitroxylated proteins, for example nitroxylated heme proteins (e.g., nitroxylated hemoglobin and nitroxylated myoglobin). The nitroxylated proteins are optionally also conjugated to a polyalkylene oxide (PAO), for example to a polyethylene glycol (PEG). Polynitroxylated heme proteins are useful as oxygen therapeutic agents (OTAs). The invention further relates to pharmaceutical compositions of the nitroxylated proteins and methods for the use of nitroxylated proteins in the treatment of various conditions.
    Type: Application
    Filed: March 15, 2013
    Publication date: April 2, 2015
    Inventors: Kim D. Vandegriff, Ashok Malavalli, Gnel Mkrtchyan
  • DIASPIRIN CROSSLINKED PEGYLATED HEMOGLOBIN
    Publication number: 20150087590
    Abstract: PEGylated diaspirin-crosslinked hemoglobin conjugates having high oxygen affinity are described which have enhanced nitrite reductase activity to deliver oxygen, carbon monoxide, nitric oxide or mixtures thereof to tissues to treat various diseases and conditions.
    Type: Application
    Filed: March 15, 2013
    Publication date: March 26, 2015
    Inventors: Kim D. Vandegriff, Ashok Malavalli, Scott D. Olsen
  • METHODS FOR PREPARING PEG-HEMOGLOBIN CONJUGATES USING REDUCED REACTANT RATIOS
    Publication number: 20130217860
    Abstract: The present invention relates generally to methods for preparing polyethylene glycol (“PEG”) conjugated hemoglobin (“Hb”) using reduced reactant ratios. More specifically, the present invention relates to methods for preparing PEG conjugated Hb (“PEG-Hb”) with enhanced yield and purity.
    Type: Application
    Filed: February 23, 2011
    Publication date: August 22, 2013
    Applicant: SANGART, INC.
    Inventors: Ashok Malavalli, Kim D. Vandegriff
  • METHOD OF DELIVERING OXYGEN USING PEG-HEMOGLOBIN CONJUGATES WITH ENHANCED NITRITE REDUCTASE ACTIVITY
    Publication number: 20120282236
    Abstract: The present invention relates generally to methods for delivering oxygen to tissue and reducing nitrite to nitric oxide in the microvasculature. Specifically, the present invention is directed towards using a deoxygenated pegylated hemoglobin conjugate having enhanced nitrite reductase activity to deliver oxygen to tissues.
    Type: Application
    Filed: May 1, 2012
    Publication date: November 8, 2012
    Applicant: SANGART, INC.
    Inventors: Kim D. Vandegriff, Ashok Malavalli, Scott D. Olsen
  • MalPEG-Hb Conjugate-Containing Compositions for Delivering Carbon Monoxide (CO) to Cells
    Publication number: 20120094912
    Abstract: The present invention relates to compositions for delivering carbon monoxide (CO) to cells using heme proteins as carriers. In one embodiment, the present invention relates to the use of MalPEG surface modified hemoglobin to deliver CO to cells.
    Type: Application
    Filed: October 19, 2011
    Publication date: April 19, 2012
    Applicant: Sangart, Inc.
    Inventors: Robert M. WINSLOW, Kim Vandegriff, Nancy Jo Winslow, Ashok Malavalli
  • Methods and Compositions for Simultaneously Isolating Hemoglobin from Red Blood Cells and Inactivating Viruses
    Publication number: 20080138790
    Abstract: The present invention relates to methods arid compositions for isolating hemoglobin from red blood cells. Such methods and compositions also facilitate viral inactivation in a manner that allows recovery of biologically active hemoglobin. More particularly, this method relates to the use of solvents and detergents that are capable of facilitating red blood cell lysis to release hemoglobin (and solubilizing red blood cell membranes), while simultaneously inactivating viruses.
    Type: Application
    Filed: April 12, 2005
    Publication date: June 12, 2008
    Inventors: Robert M. Winslow, Kim D. Vandegriff, Ashok Malavalli