Patents by Inventor Ashok P. Aiyappa

Ashok P. Aiyappa has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods and compositions concerning canine interleukin 5
    Patent number: 6537781
    Abstract: The present invention provides the nucleotide and amino acid sequences of canine IL-5. It also sets forth a recombinant DNA molecule, and conservative variants thereof, comprising the DNA sequence of canine IL-5, and recombinant vectors such as expression vectors, comprising a DNA sequence encoding canine IL-5. Further, the invention sets forth polypeptides produced using a recombinant expression vector containing a canine IL-5 sequence. Also disclosed are compositions comprising a nucleotide sequence that is antisense to a DNA sequence encoding a component of canine IL-5, wherein the component can be the full canine IL-5 protein.
    Type: Grant
    Filed: August 10, 1999
    Date of Patent: March 25, 2003
    Assignee: IDEXX Laboratories, Inc.
    Inventors: Hongliang Guo, Robert Lawton, Brion Mermer, Ashok P. Aiyappa
  • Canine allergy therapeutic recombinant chimeric anti-IgE monoclonal antibody
    Patent number: 6504013
    Abstract: The present invention provides methods and compositions for decreasing IgE levels in dogs. The methods and compositions are useful for treating allergic symptoms in dogs. The invention may comprise chimeric canine anti-IgE monoclonal antibody compositions and methods for using the compositions in the treatment of allergy. In preferred embodiments, the compositions of the present invention may act by binding soluble IgE in plasma, or by inhibiting IgE from binding to receptors on mast cells, B cells, and basophils.
    Type: Grant
    Filed: June 12, 2000
    Date of Patent: January 7, 2003
    Assignee: Idexx Laboratories, Inc.
    Inventors: Robert L. Lawton, Ashok P. Aiyappa, Wendy W. Liu, Brion Mermer, Hongliang Guo, Eugene R. Krah, III