Patents by Inventor Ashok S. Malavalli

Ashok S. Malavalli has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods for preparing stable deoxygenated PEG-hemoglobin conjugate solutions comprising an antioxidant
    Patent number: 8609815
    Abstract: The present invention is a method for preparing stable HBOC solutions. Specifically, the method comprises the steps of deoxygenating a PEG-Hb conjugate and adding one or more antioxidants during or following the deoxygenating step to form a stabilized PEG-Hb conjugate. The Hb in the PEG-Hb conjugate is not crosslinked and the stabilized PEG-Hb conjugate has a p50 less than that of native SFH from the same animal source when measured under the same conditions. Specifically, the p50 is 6±2 mmHg or less than 10 mmHg.
    Type: Grant
    Filed: September 1, 2011
    Date of Patent: December 17, 2013
    Assignee: Sangart, Inc.
    Inventors: Kim D. Vandegriff, Ashok S. Malavalli
  • METHODS FOR PREPARING STABLE DEOXYGENATED PEG-HEMOGLOBIN CONJUGATE SOLUTIONS COMPRISING AN ANTIOXIDANT
    Publication number: 20120059153
    Abstract: The present invention is a method for preparing stable HBOC solutions. Specifically, the method comprises the steps of deoxygenating a PEG-Hb conjugate and adding one or more antioxidants during or following the deoxygenating step to form a stabilized PEG-Hb conjugate. The Hb in the PEG-Hb conjugate is not crosslinked and the stabilized PEG-Hb conjugate has a p50 less than that of native SFH from the same animal source when measured under the same conditions. Specifically, the p50 is 6±2 mmHg or less than 10 mmHg.
    Type: Application
    Filed: September 1, 2011
    Publication date: March 8, 2012
    Applicant: Sangart, Inc.
    Inventors: Kim D. VANDEGRIFF, Ashok S. Malavalli
  • Method for making polyalkylene oxide modified hemoglobin
    Patent number: 8021858
    Abstract: The present invention is a method for preparing a hemoglobin based oxygen carrier to deliver oxygen to tissue. The method comprises mixing a deoxygenated hemoglobin with a maleimide-activated polyakylene oxide (PAO) to obtain an oxygen carrying product. This product is characterized as having 2 to about 8 PAO moieties covalently bound to a deoxygenated hemoglobin and a p50 less than native stroma-free hemoglobin from the same animal source when measured under the same conditions.
    Type: Grant
    Filed: August 6, 2009
    Date of Patent: September 20, 2011
    Assignee: Sangart, Inc.
    Inventors: Kim D. Vandegriff, Ashok S. Malavalli, Gnel M. Mkrtchyan
  • METHOD FOR MAKING POLYALKYLENE OXIDE MODIFIED HEMOGLOBIN
    Publication number: 20100075379
    Abstract: The present invention is a method for preparing a hemoglobin based oxygen carrier to deliver oxygen to tissue. The method comprises mixing a deoxygenated hemoglobin with a maleimide-activated polyakylene oxide (PAO) to obtain an oxygen carrying product. This product is characterized as having 2 to about 8 PAO moieties covalently bound to a deoxygenated hemoglobin and a p50 less than native stroma-free hemoglobin from the same animal source when measured under the same conditions.
    Type: Application
    Filed: August 6, 2009
    Publication date: March 25, 2010
    Applicant: Sangart, Inc.
    Inventors: Kim D. Vandegriff, Ashok S. Malavalli, Gnel M. Mkrtchyan