Abstract: There is provided a weather proof pressure sensitive adhesive tape composition having 15 years or more dwell time in ambient conditions, comprising ambient humidity in the range of RH 30% to 100% RH including aggressive under water conditions, ambient pressures in the range of 0.75 bar to 1.5 bar at normal temperature, ambient temperature in the range of (?) 30° C. to 75° C. at normal pressure, ambient acidity and alkalinity in the range of pH 4.5 to pH 10.5 in water, ambient salinity of water in under water conditions of up to 1.2 mole equivalent of sodium chloride and ambient surface fluid resistance of up to 2.7×10?3 cubic meter per second per meter contact edge of the tape.

Abstract: Disclosed is a re-usable an integrated wearable suit (100) including battery powered ventilation for providing protective shield with complete safety from viral and bacterial loads, and a transparent head shield (102), a microphone (116) with dual speakers (118) for peer communication, a microsensor (107) for filter clogging sensing, alarm display device and amplifier connected to re-chargeable battery backup (108), a torso (120) including chain covered with a sealable flap facilitating the opening and closing of the kit, a lower body part (136) extending from mid hip to ankle and shaped for movement comfort of both legs and bending and sitting freedom, a pair of shoes covers (138) with a gripped bottom (140), with earthed anti-static and low voltage safety and a plurality of restricted one way air outlets (142).

Abstract: The present invention relates to a re-usable head gear (100). The re-usable head gear (100) includes a fan and filter assembly (102), a replaceable multi-layered filter assembly (104), air leakage proof housing (106), a fan inlet (108) a strain gauge mechanism (112), a tube housing (114), a head band (116), a neck band (118), a low voltage wiring (120), a micro plug and socket assembly (122), an anti-static wire mesh tape (124), a customized hybrid microcircuit amplifier (128), external speakers (130), high clarity hi-fidelity dual speakers (132), and a microphone (134).

Abstract: A multi-layered replaceable filter assembly (100) and a microfilter assembly (200) for providing safety from external exposure. The multi-layered micro filter assembly includes plurality of filter membranes. A first filter membrane (104) prevents particles greater than 10 micron from entering the multi-layered replaceable filter assembly (100). A second filter membrane (106) has embedded activated carbon that destroys micro-organisms including viruses and bacteria. As we go further downstream, the fiber density per cm keeps increasing with the filter membranes. A fifth filter membrane (112) made up of a combination of crabyon fiber and electro-spun nano fibers provides comfort and anti-allergic effect. A sixth filter membrane (114) lowers the velocity of air that occurs from breathing and a method thereof.

Abstract: A system and method for determining the exact pair of alleles corresponding to polymorphic genes from sequencing data and for using the polymorphic gene information in formulating an immunogenic composition. Reads from a sequencing data set mapping to the target polymorphic genes in a canonical reference genome sequence, and reads mapping within a defined threshold of the target gene sequence locations are extracted from the sequencing data set. Additionally, all reads from the set data set are matched against a probe reference set, and those reads that match with a high degree of similarity are extracted. Either one, or a union of both these sets of extracted reads are included in a final extracted set for further analysis. Ethnicity of the individual may be inferred based on the available sequencing data which may then serve as a basis for assigning prior probabilities to the allele variants. The extracted reads are aligned to a gene reference set of all known allele variants.

Abstract: There is provided a weather proof pressure sensitive adhesive tape composition having 15 years or more dwell time in ambient conditions, comprising ambient humidity in the range of RH 30% to 100% RH including aggressive under water conditions, ambient pressures in the range of 0.75 bar to 1.5 bar at normal temperature, ambient temperature in the range of (?) 30° C. to 75° C. at normal pressure, ambient acidity and alkalinity in the range of pH 4.5 to pH 10.5 in water, ambient salinity of water in under water conditions of up to 1.2 mole equivalent of sodium chloride and ambient surface fluid resistance of up to 2.7×10?3 cubic meter per second per meter contact edge of the tape.

Abstract: Disclosed herein in one aspect is a pharmaceutical composition comprising a plurality of neoantigenic peptides and a pharmaceutically acceptable carrier, each neoantigenic peptide comprising a tumor-specific neoepitope capable of binding to an HLA protein in a subject, each tumor-specific neoepitope comprising a tumor-specific mutation present in a tumor, wherein (a) the composition comprises neoantigenic peptides comprising tumor-specific mutations present in at least 1% of subjects in a population of subjects suffering from cancer; (b) the composition comprises neoantigenic peptides comprising tumor-specific neoepitopes which bind to HLA proteins present in at least 5% of subjects in the population; and (c) the composition comprises at least one neoantigenic peptide capable of eliciting an immune response against a tumor present in at least 5% of the subjects in the population of subjects suffering from cancer.

Abstract: Systems and methods for verifiable, private and secure omic analysis are provided. Secure multiparty computation techniques can be utilized to enable two parties to perform an omic transaction, such as determining genetic compatibility with one another, by jointly computing a result without either party disclosing their genetic information to the other. Privacy-preserving techniques to ensure authenticity of each party's omic data and metadata are also provided. Personalized matching scores can be computed, in which each party's score is weighted to reflect user preferences associated with the matching analysis.

Abstract: Disclosed herein in one aspect is a pharmaceutical composition comprising a plurality of neoantigenic peptides and a pharmaceutically acceptable carrier, each neoantigenic peptide comprising a tumor-specific neoepitope capable of binding to an HLA protein in a subject, each tumor-specific neoepitope comprising a tumor-specific mutation present in a tumor, wherein (a) the composition comprises neoantigenic peptides comprising tumor-specific mutations present in at least 1% of subjects in a population of subjects suffering from cancer; (b) the composition comprises neoantigenic peptides comprising tumor-specific neoepitopes which bind to HLA proteins present in at least 5% of subjects in the population; and (c) the composition comprises at least one neoantigenic peptide capable of eliciting an immune response against a tumor present in at least 5% of the subjects in the population of subjects suffering from cancer.

Abstract: In accordance with an embodiment, described herein is a system and method for automatic migration of poller proxy services in a service bus environment. A singleton service framework component keeps a poller singleton application running on any of the managed servers in the cluster. The poller singleton application is registered with a cluster change listener, which listens for any state change in the cluster. Each poller proxy service is homogeneously deployed on each managed server in the cluster, and is associated with a poller engine configured to run on a particular managed server. When a managed server fails, the poller singleton application can migrate each poller engine configured to run on the failed managed server, to a running managed server, based on a preferred server list of the poller proxy service associated with that poller engine.

Abstract: Systems and methods for conducting secure, privacy-preserving, verifiable omic transactions are provided. An omic service may authenticate one or more individual users and store each users omic information as encrypted data, without storing decryption keys, and also ensure fidelity and correct correspondence of each user's data with the user. A dedicated private virtual appliance can be instantiated to obtain encrypted omic data, query each user for decryption keys, decrypt the user omic data, perform an omic calculation, report results and terminate itself, thereby erasing all copies of decrypted user omic data. Alternatively, the appliance can operate with user-managed genome storage. A genome-on-a-stick construct facilitates end user interaction with such omic service providers.

Abstract: In accordance with an embodiment, described herein is a system and method for automatic migration of poller proxy services in a service bus environment. A singleton service framework component keeps a poller singleton application running on any of the managed servers in the cluster. The poller singleton application is registered with a cluster change listener, which listens for any state change in the cluster. Each poller proxy service is homogeneously deployed on each managed server in the cluster, and is associated with a poller engine configured to run on a particular managed server. When a managed server fails, the poller singleton application can migrate each poller engine configured to run on the failed managed server, to a running managed server, based on a preferred server list of the poller proxy service associated with that poller engine.

Abstract: A system and method for determining the exact pair of alleles corresponding to polymorphic genes from sequencing data and for using the polymorphic gene information in formulating an immunogenic composition. Reads from a sequencing data set mapping to the target polymorphic genes in a canonical reference genome sequence, and reads mapping within a defined threshold of the target gene sequence locations are extracted from the sequencing data set. Additionally, all reads from the set data set are matched against a probe reference set, and those reads that match with a high degree of similarity are extracted. Either one, or a union of both these sets of extracted reads are included in a final extracted set for further analysis. Ethnicity of the individual may be inferred based on the available sequencing data which may then serve as a basis for assigning prior probabilities to the allele variants. The extracted reads are aligned to a gene reference set of all known allele variants.

Abstract: Systems and methods for verifiable, private and secure omic analysis are provided. Secure multiparty computation techniques can be utilized to enable two parties to perform an omic transaction, such as determining genetic compatibility with one another, by jointly computing a result without either party disclosing their genetic information to the other. Privacy-preserving techniques to ensure authenticity of each party's omic data and metadata are also provided. Personalized matching scores can be computed, in which each party's score is weighted to reflect user preferences associated with the matching analysis.

Abstract: In the present invention, we describe a device and a method that shows the use of a perforated surface (e.g. net, grid, mesh etc.) for the preparation of small biological and chemical samples. In this present invention, the sample is concentrated on the edges of the perforation. If a solution of chemical or biological sample is applied on the perforated area; upon drying the solvent, the solute will concentrate on the edges of the perforation. This offers a novel method for the sample concentration. The perforated surface can be directly placed in the MALDI instrument for sample analysis. Furthermore, the edges of the perforation of the perforated surface can be modified, treated or coated with different chromatographic materials and thus have the retention property for analyzing the molecules. The woven net may contain not just single but double or more threads that creates a capillary effect, which further enhances the sample purification and concentration.

Abstract: The present invention relates to a novel device for transport of chemicals and biochemicals in small amounts such as in microgram range. For example, a pipette tip, or a film containing chromatographic media, wherein the media contains an enzyme for the enzymic action. The enzyme is adsorbed on the surface of the chromatographic media and is non-covalently bound. These enzyme containing tips will be used for the transport of very small amounts of enzyme to the sample, where the biochemical reaction takes place. They will also be used in a buffer where the enzyme will be kept adsorbed on the chromatographic media and will not dissociate from chromatographic media and the substrate will react with the enzyme on the surface of the media. Furthermore, the presence of chromatographic media can be used simultaneously for the purification of the reaction product from the buffer components.

Abstract: This invention describes a novel DBFC employing hydrogen peroxide as oxidant with a power density of about 350 mW/cm2 at the cell voltage of almost 1.2V at 70° C.; the open-circuit voltage of the DBFC being as high as about 2V, the use of liquid reactants in DBFCs not only simplifies the engineering problems at the front end of the fuel cell driving down complexity and hence cost but operating a DBFC with an oxidant such as hydrogen peroxide also extends the operational domain of fuel cells to locations where free convection of air is limited, e.g. under water applications.