Abstract: Ultrasound systems and methods for automatically determining heart chamber characteristics are provided. The systems and methods of the present invention, for example, can automatically determine chamber pressures and volumes of a patient's heart using a transthoracic or transesophageal ultrasound probe imaging the heart in 2D and/or 3D. Chamber pressures determined include the static pressure of the left ventricular end diastolic pressure, which can be used to diagnose whether a patient is suffering from congestive heart failure.