Patents by Inventor Ashok V. Bhatia

Ashok V. Bhatia has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for the preparation of iopamidol
    Patent number: 7282607
    Abstract: The present invention discloses a process for the preparation of pure non-ionic contrast agents. The invention also includes a method for purifying the non-ionic contrast agents.
    Type: Grant
    Filed: August 16, 2006
    Date of Patent: October 16, 2007
    Assignee: Bracco Imaging, S.p.A.
    Inventors: Richard A. Lorenzini, Ashok V. Bhatia, Steven A. Chamberlin, Keith A. Drengler, John J. Hufnagel, Xiu C. Wang
  • Process for the preparation of iopamidol
    Patent number: 7115778
    Abstract: The present invention discloses a process for the preparation of pure non-ionic contrast agents. The invention also includes a method for purifying the non-ionic contrast agents.
    Type: Grant
    Filed: February 24, 2005
    Date of Patent: October 3, 2006
    Assignee: Bracco imaging, S.p.A.
    Inventors: Richard A. Lorenzini, Ashok V. Bhatia, Steven A. Chamberlin, Keith A. Drengler, John J. Hufnagel, Xiu C. Wang
  • Process for the preparation of iopamidol
    Patent number: 6875887
    Abstract: A compound and salts and enantiomers thereof, having the formula: wherein R7 is an acyl group.
    Type: Grant
    Filed: June 16, 2004
    Date of Patent: April 5, 2005
    Assignee: Bracco Imaging S.p.A.
    Inventors: Richard A. Lorenzini, Ashok V. Bhatia, Steven A. Chamberlin, Keith A. Drengler, John J. Hufnagel, Xiu C. Wang
  • Process for the preparation of iopamidol
    Publication number: 20040236150
    Abstract: The present invention discloses a process for the preparation of pure non-ionic contrast agents. The invention also includes a method for purifying the non-ionic contrast agents.
    Type: Application
    Filed: June 16, 2004
    Publication date: November 25, 2004
    Inventors: Richard A. Lorenzini, Ashok V. Bhatia, Steven A. Chamberlin, Keith A. Drengler, John J. Hufnagel, Xiu C. Wang
  • Process for the preparation of iopamidol
    Patent number: 6803485
    Abstract: The present invention discloses a process for the preparation of pure non-ionic contrast agents. The invention also includes a method for purifying the non-ionic contrast agents.
    Type: Grant
    Filed: February 26, 1999
    Date of Patent: October 12, 2004
    Assignee: Bracco Imaging S.p.A.
    Inventors: Richard A. Lorenzini, Ashok V. Bhatia, Steven A. Chamberlin, Keith A. Drengler, John J. Hufnagel, Xiu C. Wang
  • Process for the preparation of Midazolam
    Patent number: 6512114
    Abstract: The present invention provides a process for the synthesis of Midazolam I from a compound of formula II, using thermodynamic, basic workup conditions. Additional steps to isolate the pure bulk product follow.
    Type: Grant
    Filed: June 30, 1999
    Date of Patent: January 28, 2003
    Assignee: Abbott Laboratories
    Inventors: Madhup K. Dhaon, Grant L. Esser, Deborah A. Davis, Ashok V. Bhatia
  • Process for producing 13-cis retinoic acid
    Publication number: 20010018533
    Abstract: The process of the present invention relates to a process for producing 1 3-cis retinoic acid. The process of the present invention involves reacting a Wittig salt in a solvent with a butenolide in the presence of a weak base and optionally, a Lewis acid.
    Type: Application
    Filed: January 18, 2000
    Publication date: August 30, 2001
    Inventors: Xiu C. Wang, Ashok V. Bhatia, Azad Hossain, Timothy B. Towne
  • Process for producing 13-cis retinoic acid
    Patent number: 6124485
    Abstract: The process of the present invention relates to a process for producing 1 3-cis retinoic acid. The process of the present invention involves reacting a Wittig salt in a solvent with a butenolide in the presence of a weak base and a Lewis acid.
    Type: Grant
    Filed: March 25, 1998
    Date of Patent: September 26, 2000
    Assignee: Abbott Laboratories
    Inventors: Xiu C. Wang, Ashok V. Bhatia, Azad Hossain, Timothy B. Towne
  • Process for the selective alkylation of betaxolol intermediates
    Patent number: 5942633
    Abstract: The present invention relates to a process for the selective alkylation of intermediates of betaxolol.
    Type: Grant
    Filed: June 19, 1996
    Date of Patent: August 24, 1999
    Assignee: Abbott Laboratories
    Inventors: Xiu C. Wang, Luping Liu, Ashok V. Bhatia
  • Processes for the preparation of D-chiro-inositol
    Patent number: 5932774
    Abstract: A method for the preparation of D-chiro-inositol from kasugamycin, comprising the steps of: (a) reacting kasugamycin with an acetylating agent to form a crude hexa-acetate intermediate; (b) purifying the crude intermediate to form purified hexa-acetate intermediate; (c) deacetylating the purified intermediate to form D-chiro-inositol; and (d) isolating the D-chiro-inositol. The method permits efficient, large-scale preparation of D-chiro-inositol without the need for extensive chromatographic purification of the final D-chiro-inositol product.
    Type: Grant
    Filed: November 6, 1995
    Date of Patent: August 3, 1999
    Assignee: Abbott Laboratories
    Inventors: David A. Riley, Ashok V. Bhatia, Steven A. Chamberlin, Gregg E. Robinson
  • Process for the preparation of polyanhydrides
    Patent number: 5905134
    Abstract: Polymers can be prepared in solution by continuously distilling solvent from a solution of diacid prepolymers.
    Type: Grant
    Filed: April 4, 1997
    Date of Patent: May 18, 1999
    Assignee: Abbott Laboratories
    Inventors: John J. Hufnagel, Ashok V. Bhatia, David A. Riley, Greg E. Robinson
  • Process for the preparation of iohexol
    Patent number: 5847212
    Abstract: Provided is a novel process for the preparation of iohexol having reduced number of isolated intermediates and significantly reduces or eliminates the use of ion-exchange resins required to desalinate the final product.
    Type: Grant
    Filed: April 21, 1997
    Date of Patent: December 8, 1998
    Assignee: Abbott Laboratories
    Inventors: Xiu Chun Wang, Ashok V. Bhatia, Steven A. Chamberlin
  • Selective alkylation of an alcohol substituted phenol compound
    Patent number: 5731463
    Abstract: The present invention relates to a process for the selective alkylation of intermediates of betaxolol.
    Type: Grant
    Filed: September 23, 1996
    Date of Patent: March 24, 1998
    Assignee: Abbott Laboratories
    Inventors: Xiu C. Wang, Ashok V. Bhatia, Steven Chamberlin, Luping Liu
  • Process for the preparation of iohexol
    Patent number: 5705692
    Abstract: Provided is a novel process for the preparation of iohexol having improved yields and purity, reduced number of isolated intermediates, and significantly reduced volume of ion-exchange resins required to desalinate the final product.
    Type: Grant
    Filed: September 27, 1996
    Date of Patent: January 6, 1998
    Assignee: Abbott Laboratories
    Inventors: Xiu C. Wang, Steve A. Chamberlin, Ashok V. Bhatia, Gregg E. Robinson, John Hufnagel
  • Process for the preparation and isolation of atracurium besylate
    Patent number: 5684154
    Abstract: A process of producing atracurium besylate that substantially reduces the level of impurities in the final product and avoids the repeated use of ether is provided. In accordance with such a process, N, N'-4,10-dioxa-3,11-dioxotridecylene-1,13-bis-tetrahydropapaverine (Compound 1), methyl benzenesulfonate and a catalytic amount of an insoluble base in a solvent are combined to form a reaction mixture that is maintained for a period of time sufficient for atracurium besylate formation. The reaction mixture is then filtered to remove the insoluble base and the atracuriurn besylate is precipitated.
    Type: Grant
    Filed: February 16, 1996
    Date of Patent: November 4, 1997
    Assignee: Abbott Laboratories
    Inventors: Steven A. Chamberlin, Ashok V. Bhatia, Deborah A. Davis, Keith A. Drengler
  • Method for the preparation of D-chiro-inositol
    Patent number: 5463142
    Abstract: A method for the preparation of D-chiro-inositol from kasugamycin, comprising the steps of:(a) reacting kasugamycin with an acetylating agent to form a crude hexa-acetate intermediate;(b) purifying the crude intermediate to form purified hexa-acetate intermediate;(c) deacetylating the purified intermediate to form D-chiro-inositol; and(d) isolating the D-chiro-inositol.The method permits efficient, large-scale preparation of D-chiro-inositol without the need for extensive chromatographic purification of the final D-chiro-inositol product.
    Type: Grant
    Filed: November 10, 1994
    Date of Patent: October 31, 1995
    Assignee: Abbott Laboratories
    Inventors: David A. Riley, Steven A. Chamberlin, Ashok V. Bhatia