Abstract: The invention relates to new formulations of compounds having activity against HCV-associated disorders, new combinations, new methods of treatment and their use in therapy.

Abstract: A method of transmitting data is disclosed. At least one system block of a system-on-chip (SoC) is modeled at an untimed functional level in first and second untimed functional models. First and second transaction level (TL) models of the at least one system block system block are modeled at a transaction level (TL) using the first and second untimed functional models, respectively. First and second cycle accurate (CA) models are modeled at a cycle accurate (CA) level using the first and second TL models, respectively. Data is transmitted from the first untimed functional model to the first CA model, from the first CA model to the second CA model via a CA bus, and from the second CA model to the second untimed functional model.

Abstract: A computer-based method for contingency analysis of oscillatory stability in an electrical power transmission system is provided. The method uses at least one processor. The method includes receiving, by the at least one processor, a plurality of component inputs from a plurality of system components within the electrical power transmission system. The method also includes generating a nominal matrix for the electrical power transmission system. The nominal matrix includes a set of equations at least partially modeling the electrical power transmission system. The method further includes calculating eigenvalues and eigenvectors of the nominal matrix. The method also includes identifying a contingency representing a postulated disturbance of the electrical power transmission system. The method further includes estimating a contingency eigenvalue for the contingency using the eigenvalues and eigenvectors of the nominal matrix.

Abstract: Controlled startup of devices is based on dynamic statistical predictions. Timely startup of onboard associated vehicle devices is based on dynamic statistical predictions and driver proximity to the vehicle. An apparatus for timely startup includes an interface operatively coupled with a power consuming device and control logic coupled with the interface. The control logic is operable in a first mode to perform processing for determining a presence of a first condition of the vehicle, and to selectively activate the power consuming device of the vehicle, via the interface, responsive to determining the presence of the first condition. The control logic is operable in a second mode to suspend, via the interface, the processing for determining the presence of the first condition of the vehicle. The control logic selectively transitions between the first and second modes in accordance with a stochastic modeling of the presence of the first condition over time.

Abstract: The present invention relates to improved and integrated methods for the characterisation of an interaction site on a target protein that modulates the phenotype of a mammalian cell, such as a phenotype other than death and/or reduced growth. Such methods of the present invention include those to identify a target protein modulates such a phenotype of a mammalian cell, and optionally to characterise an interaction site on said target protein. Such identification and characterisation methods are useful in the development of research tools and/or therapeutics, such protein/peptide or small molecule therapeutics. Accordingly, the present invention also relates to methods of: identification of a ligand, such as a small molecule ligand, that binds to such a target protein; and identification a compound being a candidate modulator of said phenotype of a mammalian cell.

Abstract: Methods of genome sequencing of a fetus are provided herein. In some embodiments, such methods include steps of predicting inheritance or transmission of an allele from one or more maternal-only heterozygous sites from a maternal genomic sequence to a fetal genome sequence; and predicting inheritance or transmission of an allele from one or more paternal-only heterozygous sites from a paternal genomic sequence to a fetal genome sequence. In some embodiments, the methods may also include predicting transmission of one or more genomic variants at one or more heterozygous sites that are present on both a maternal genomic sequence and a paternal genomic sequence. According to these embodiments, the paternal genomic sequence and the maternal genomic sequence are derived from a biological sample containing DNA. According to other embodiments, the sequencing methods may include a step of predicting de novo mutations in a fetal genomic sequence.

Abstract: In an example an integral wiring box comprises: a circular base having a base wire access point; a side wall extended from a perimeter edge of the base forming a cavity having an internal surface and an external surface and a side wall wire access point; a base conduit extending from the base wire access point into the cavity; a side wall conduit extending from the side wall wire access point into the cavity; an internal mounting projection extending from the internal surface of the side wall into the cavity and free from attachment to the circular base, the internal mounting projection further comprising a mounting hole; and an external mounting projection extending from the external surface of the side wall away from the base, the external mounting projection further comprising a mounting hole; wherein a single mounting hub extends from the base into the cavity, wherein the base, side wall, internal mounting projection, external mounting projection, and mounting hub, are formed as a single component.

Abstract: This invention handles write request cache misses. The cache controller stores write data, sends a read request to external memory for a corresponding cache line, merges the write data with data returned from the external memory and stores merged data in the cache. The cache controller includes buffers with plural entries storing the write address, the write data, the position of the write data within a cache line and unique identification number. This stored data enables the cache controller to proceed to servicing other access requests while waiting for response from the external memory.

Abstract: A nacelle assembly for a turbine engine has a cowl for a turbine engine. The cowl has a first surface spaced from a second surface. The second surface defines defining a bypass flow passage. A flow volume is spaced between the first surface and the second surface. A plurality of holes are disposed on the cowl. Each of the plurality of holes are configured to alter local air pressure about one of the first surface and the second surface of the cowl. The plurality of holes are in communication with the flow volume.

Abstract: A method, system and computer program product for efficiently configuring different types of hardware components. A computing device is connected to a hardware component to be configured. The computing device detects the type of the hardware component upon being connected to the hardware component. The computing device then identifies a profile from among multiple profiles associated with the detected type of hardware component, where each profile contains a configuration file(s) for configuring its associated type of hardware component. Upon identifying the profile associated with the connected hardware component, the computing device emulates a Universal Serial Bus (USB) key presenting the configuration file(s) contained in the identified profile to the detected hardware component. Such a process may be repeated for configuring another type of hardware component. In this manner, the user is able to efficiently configure different types of hardware by having the computing device emulate multiple USB keys.

Abstract: The invention concerns apolymer of the formula (I): wherein: M1 is an optionally substituted dithienophthalimide formula (II): wherein: X is N or C—R, wherein R is H or a C1-C40 alkyl group, R2, at each occurrence, is independently selected from H, a C1-40 alkyl group, a C2-40 alkenyl group, a C1-40 haloalkyl group, and a monocyclicor polycyclic moiety, wherein: each of the C1-40 alkyl group, the C2-40 alkenyl group, and the C1-40 haloalkyl group can be optionally substituted with 1-10 substituents independently selected from a halogen, CN, —NO2, OH, NH2, —NH(C1-20 alkyl), N(C1-20 alkyl)2, —S(O)2OH, —CHO, —C(O)—C1-20 alkyl, —C(O)OH, —C(O)—OC1-20 alkyl, —C(O)NH2, —C(O)NH—C1-20 alkyl, —C(O)N(C1-20 alkyl)2, —OC1-20 alkyl, —SiH3, —SiH(C1-20 alkyl)2, —SiH2(C1-20 alkyl), and —Si(C1-20 alkyl)3; and the monocyclic or polycyclic moiety can be covalently bonded to the imide nitrogen via an optional linker, and can be optionally substituted with 1-5 substituentsindependently selected from a halogen, oxo, —CN, —NO2, OH,

Abstract: A process for upgrading an oil stream by mixing the oil stream with a water stream and subjecting it to conditions that are at or above the supercritical temperature and pressure of water. The process further includes cooling and a subsequent alkaline extraction step. The resulting thiols and hydrogen sulfide gas can be isolated from the product stream, resulting in an upgraded oil stream that is a higher value oil having low sulfur, low nitrogen, and low metallic impurities as compared to the oil stream.

Abstract: Methods and apparatus for timing synchronization based on transitional pilot symbols. In an aspect, a method is provided for time tracking synchronization in an OFDM system. The method includes receiving at least one TDM pilot symbol comprising a plurality of modulated sub-carriers that are configured to provide a channel estimate having a length that extends up to a duration of an FFT used for data transmission. The method also includes determining one or both of an instantaneous and averaged channel estimates from the plurality of modulated sub-carriers, and calculating a timing offset based on one or both of the channel estimates. An apparatus includes a receiver configured to receive the at least one TDM pilot symbol, a channel estimator configured to determine the instantaneous and averaged channel estimates, and a time synchronizer configured to calculate a timing offset based on the channel estimates.

Abstract: Disclosed embodiments include electromagnetic flow regulators for regulating flow of an electrically conductive fluid, systems for regulating flow of an electrically conductive fluid, methods of regulating flow of an electrically conductive fluid, nuclear fission reactors, systems for regulating flow of an electrically conductive reactor coolant, and methods of regulating flow of an electrically conductive reactor coolant in a nuclear fission reactor.

Abstract: Techniques and systems are presented for providing “contextual insights,” or information that is tailored to the context of the content a user is consuming or authoring. Given a request for information about a topic, which may be indicated by a user gesture in an application, one or more queries to search services may be formulated without requiring entry of a search query directly by a user. Moreover, techniques and systems may leverage the context of the content the user is consuming or authoring, as well as user, device, and application metadata, to construct the queries and to organize and filter the results into relevant contextual insights.

Abstract: Techniques described herein provide a method for defining virtual content for real objects that are unknown or unidentified at the time of the development of the application for an augmented reality (AR) environment. For example, at the time of development of an AR application, the application developer may not know the context that the mobile device may operate in and consequently the types or classes of real object and the number of real objects that the AR application may encounter. In one embodiment, the mobile device may detect unknown objects from a physical scene. The mobile device may then associate an object template with the unknown object based on the physical attributes, such as height, shape, size, etc., associated with the unknown object. The mobile device may render a display object at the pose of the unknown object using at least one display property of the object template.

Abstract: A chip package includes an optical integrated circuit (such as a hybrid integrated circuit) and an integrated circuit that are adjacent to each other on the same side of a substrate in the chip package. The integrated circuit includes electrical circuits, such as memory or a processor, and the optical integrated circuit communicates optical signals with very high bandwidth. In addition, an input/output (I/O) integrated circuit is coupled to the optical integrated circuit between the substrate and the optical integrated circuit. This I/O integrated circuit includes high-speed I/O circuits and energy-efficient driver and receiver circuits and communicates with optical devices on the optical integrated circuit. By integrating the optical integrated circuit, the integrated circuit and the I/O integrated circuit in close proximity, the chip package may facilitate improved performance compared to chip packages with electrical interconnects.

Abstract: A master device for providing a mirroring service is provided. The master device includes a display unit that displays a certain screen, a control unit configured to generate high image-quality data of a first region mirrored by a client device in the certain screen, and to generates low image-quality data of a second region which is not mirrored by the client device, and a communication unit configured to transmit the high image-quality data and the low image-quality data to the client device.

Abstract: Described herein is a technology for facilitating policy management. In accordance with one aspect, the technology includes, but is not limited to, gathering of personal data related to users, and determining policy topics that are relevant to the specific users based on their personal profile and other criteria as defined by the users. Policy updates, including new policies or changes to the existing ones, which are most relevant to the users may further be provided in a systematic way.

Abstract: Power saving for wireless communication devices by adjusting the amount of time, after a last transmission/reception of data, that the device remains in an awake mode listening for more data before the device enters a sleep mode. This time period may be referred to as inactivity time interval or inactivity timeout (ITO). The described features may be employed to improve power savings by taking metrics of channel congestion into account for determining the ITO. The appropriate ITO may be determined to be commensurate with ongoing transmission and/or reception activity. Because error may occur in estimating channel congestion and/or transmission/reception activity, latency bounds based on estimation errors may be managed by classifying the operational mode into multiple regions and employing techniques for mitigating error in congestion estimation based at least in part on the operational mode.