Patents by Inventor Ashraf B. Abdel-Naim

Ashraf B. Abdel-Naim has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11559495
    Abstract: A nano-pharmaceutical formulation, comprising zein nanoparticles, icariin (ICA) or a pharmaceutically acceptable salt thereof encapsulated within the zein nanoparticles, at least one solubilizer, wherein the at least one solubilizer comprises D-a-Tocopherol polyethylene glycol 1000 succinate (TPGS), and one or more pharmaceutical penetration enhancers is provided. Methods of enhancing libido by administering a composition as described herein is also provided.
    Type: Grant
    Filed: March 7, 2022
    Date of Patent: January 24, 2023
    Assignee: KING ABDULAZIZ UNIVERSITY
    Inventors: Hani Z. Asfour, Nabil A. Alhakamy, Raed I. Felimban, Osama A. A. Ahmed, Waleed Y. Rizg, Usama A. Fahmy, Ashraf B. Abdel-Naim
  • Patent number: 11497765
    Abstract: Thioctamer, a nanoconjugate of glatiramer acetate (GA) and thioctic acid (TA), e.g. in the form of nanospheres, is provided as are compositions comprising thioctamer and methods of using the same for wound healing. Application of thioctamer to a wound accelerates wound healing, compared to control wounds that are not treated with the copolymer.
    Type: Grant
    Filed: February 27, 2022
    Date of Patent: November 15, 2022
    Assignee: KING ABDULAZIZ UNIVERSITY
    Inventors: Nabil A. Alhakamy, Usama A. Fahmy, Osama A. A. Ahmed, Basma G. Eid, Mohammed Z. Nasrullah, Ashraf B. Abdel-naim, Amgad Khedr, Gamal A. Mohamed, Mohamed W. Alrabei, Sabrin R. M. Ibrahim
  • Patent number: 11220485
    Abstract: Cytotoxic compounds containing a phenyl core, amide link(s), an imidazolinone or a propenamide moiety. Also described are pharmaceutical compositions incorporating the cytotoxic compounds and methods for treating cancer. These compounds are cytotoxic against breast, prostate, and leukemia cancer cell lines via dual inhibition of Src kinases and tubulin.
    Type: Grant
    Filed: July 16, 2021
    Date of Patent: January 11, 2022
    Assignee: King Abdulaziz University
    Inventors: Moustafa E. El-Araby, Abdelsattar M. Omar, Ahmed Esmat, Farid Ahmed, Azizah M. Malebari, Ashraf B. Abdel-Naim, Thikryat Neamatallah
  • Patent number: 11180458
    Abstract: Cytotoxic compounds containing a phenyl core, amide link(s), an imidazolinone or a propenamide moiety. Also described are pharmaceutical compositions incorporating the cytotoxic compounds and methods for treating cancer. These compounds are cytotoxic against breast, prostate, and leukemia cancer cell lines via dual inhibition of Src kinases and tubulin.
    Type: Grant
    Filed: November 12, 2019
    Date of Patent: November 23, 2021
    Assignee: King Abdulaziz University
    Inventors: Moustafa E. El-Araby, Abdelsattar M. Omar, Ahmed Esmat, Farid Ahmed, Azizah M. Malebari, Ashraf B. Abdel-Naim, Thikryat Neamatallah
  • Patent number: 11174233
    Abstract: Cytotoxic compounds containing a phenyl core, amide link(s), an imidazolinone or a propenamide moiety. Also described are pharmaceutical compositions incorporating the cytotoxic compounds and methods for treating cancer. These compounds are cytotoxic against breast, prostate, and leukemia cancer cell lines via dual inhibition of Src kinases and tubulin.
    Type: Grant
    Filed: July 16, 2021
    Date of Patent: November 16, 2021
    Assignee: King Abdulaziz University
    Inventors: Moustafa E. El-Araby, Abdelsattar M. Omar, Ahmed Esmat, Farid Ahmed, Azizah M. Malebari, Ashraf B. Abdel-Naim, Thikryat Neamatallah
  • Publication number: 20210340110
    Abstract: Cytotoxic compounds containing a phenyl core, amide link(s), an imidazolinone or a propenamide moiety. Also described are pharmaceutical compositions incorporating the cytotoxic compounds and methods for treating cancer. These compounds are cytotoxic against breast, prostate, and leukemia cancer cell lines via dual inhibition of Src kinases and tubulin.
    Type: Application
    Filed: July 16, 2021
    Publication date: November 4, 2021
    Applicant: King Abdulaziz University
    Inventors: Moustafa E. EL-ARABY, Abdelsattar M. Omar, Ahmed Esmat, Farid Ahmed, Azizah M. Malebari, Ashraf B. Abdel-Naim, Thikryat Neamatallah
  • Publication number: 20210139434
    Abstract: Cytotoxic compounds containing a phenyl core, amide link(s), an imidazolinone or a propenamide moiety. Also described are pharmaceutical compositions incorporating the cytotoxic compounds and methods for treating cancer. These compounds are cytotoxic against breast, prostate, and leukemia cancer cell lines via dual inhibition of Src kinases and tubulin.
    Type: Application
    Filed: November 12, 2019
    Publication date: May 13, 2021
    Applicant: King Abdulaziz University
    Inventors: Moustafa E. EL-ARABY, Abdelsattar M. OMAR, Ahmed ESMAT, Farid AHMED, Azizah M. MALEBARI, Ashraf B. ABDEL-NAIM, Thikryat NEAMATALLAH
  • Patent number: 10894794
    Abstract: Compounds for the treatment of hyperglycemia and/or diabetes are provided. The compounds, which inhibit the enzyme dipeptidyl peptidase (DPP-4), are based on the structure where n1=0-2 such as 0 or 1; R1 is i) a saturated or unsaturated, substituted or unsubstituted monocyclic aliphatic ring, alone or fused with cyclopropane or cyclobutene, optionally comprising one or more substituents attached to the ring; or ii) a substituted or unsubstituted monocyclic aromatic ring, optionally comprising one or more substituents attached to the ring; R2 is present or absent and if present is: C?O; (CH2)n where n=0-4; S; SO; SO2; NR where R?H, CH3 or CH2CH3; or NH(CH2)n where n=0-4; and R3 is present or absent and if present is (CH2)n where n=0-4; S; SO; SO2; NR where R?H, CH3 or CH2CH3; or NH(CH2)n where n=0-4; and salts and isomers thereof.
    Type: Grant
    Filed: December 18, 2019
    Date of Patent: January 19, 2021
    Assignee: King Abdulaziz University
    Inventors: Abdelsattar M. Omar, Mohamed A. El-Zahabi, Salah G. Atteiah, Ashraf B. Abdel-Naim, Moustafa E. El-Araby
  • Patent number: 10844022
    Abstract: Cytotoxic compounds containing a phenyl core, amide link(s), an imidazolinone or a propenamide moiety. Also described are pharmaceutical compositions incorporating the cytotoxic compounds and methods for treating cancer. These compounds are cytotoxic against breast, prostate, and leukemia cancer cell lines via dual inhibition of Src kinases and tubulin.
    Type: Grant
    Filed: August 5, 2020
    Date of Patent: November 24, 2020
    Assignee: King Abdulaziz University
    Inventors: Moustafa E. El-Araby, Abdelsattar M. Omar, Ahmed Esmat, Farid Ahmed, Azizah M. Malebari, Ashraf B. Abdel-Naim, Thikryat Neamatallah
  • Patent number: 10683267
    Abstract: Compounds for the treatment of hyperglycemia and/or diabetes are provided. The compounds, which inhibit the enzyme dipeptidyl peptidase (DPP-4), are based on the structure where X may be present or absent an may be OH, Ar is an aryl group; and n ranges from 0 to 5.
    Type: Grant
    Filed: November 21, 2019
    Date of Patent: June 16, 2020
    Assignee: KING ABDULAZIZ UNIVERSITY
    Inventors: Abdelsattar M. Omar, Mohamed A. El-Zahabi, Salah G. Atteiah, Ashraf B. Abdel-Naim, Moustafa E. El-Araby
  • Patent number: 10654800
    Abstract: Compounds for the treatment of hyperglycemia and/or diabetes are provided. The compounds, which inhibit the enzyme dipeptidyl peptidase (DPP-4), are based on the structure where X may be present or absent an may be OH, Ar is an aryl group; and n ranges from 0 to 5.
    Type: Grant
    Filed: March 16, 2020
    Date of Patent: May 19, 2020
    Assignee: KING ABDULAZIZ UNIVERISTY
    Inventors: Abdelsattar M. Omar, Mohamed A. El-Zahabi, Salah G. Atteiah, Ashraf B. Abdel-Naim, Moustafa E. El-Araby