Abstract: Systems and methods for selectively coupling one of a group of peripherals to a computer. In one embodiment, a USB switch is coupled between a computer and multiple USB peripheral devices. The switch selectively connects the computer to either a single one of the peripherals, or none of the peripherals. The switch employs a microcontroller which receives control signals from the computer and controls a switching mechanism such as a set of multiplexers or relays to connect data lines from the computer to one of the peripheral ports of the switch, while disconnecting the remainder of the peripheral ports. The switch may also disconnect all of the peripheral ports. The switch may also incorporate a display which is controlled by the switch's microcontroller. One or more power sources may be included to provide power to each of the peripheral ports.