Patents by Inventor Ashton Hamme

Ashton Hamme has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • (R)-Chiral Halogenated Substituted Fused Heterocyclic Amino Compounds Useful for Inhibiting Cholesterol Ester Transfer Protein Activity
    Publication number: 20070219274
    Abstract: The invention relates to substituted aryl and heteroaryl (R)-Chiral Halogenated 1-Substitutedamino-(n+1)-Alkanol compounds useful as inhibitors of cholesteryl ester transfer protein (CETP; plasma lipid transfer protein-I) and compounds, compositions and methods for treating atherosclerosis and other coronary artery diseases. Novel high yield, stereoselective processes for the preparation of the chiral substituted alkanol compounds from chiral and achiral intermediates are described.
    Type: Application
    Filed: March 29, 2007
    Publication date: September 20, 2007
    Inventors: James Sikorski, Richard Durley, Margaret Grapperhaus, Mark Massa, Emily Reinhard, Yvette Fobian, Michael Tollefson, Lijuan Wang, Brian Hickory, Monica Norton, William Vernier, Deborah Mischke, Michelle Promo, Ashton Hamme, Dale Spangler, Melvin Rueppel
  • (R)-chiral halogenated substituted fused heterocyclic amino compounds useful for inhibiting cholesterol ester transfer protein activity
    Publication number: 20060229304
    Abstract: The invention relates to substituted aryl and heteroaryl (R)-Chiral Halogenated 1-Substitutedamino-(n+1)-Alkanol compounds useful as inhibitors of cholesteryl ester transfer protein (CETP; plasma lipid transfer protein-I) and compounds, compositions and methods for treating atherosclerosis and other coronary artery diseases. Novel high yield, stereoselective processes for the preparation of the chiral substituted alkanol compounds from chiral and achiral intermediates are described.
    Type: Application
    Filed: March 9, 2006
    Publication date: October 12, 2006
    Inventors: James Sikorski, Richard Durley, Margaret Grapperhaus, Mark Massa, Emily Reinhard, Yvette Fobian, Michael Tollefson, Lijuan Wang, Brian Hickory, Monica Norton, William Vernier, Deborah Mischke, Michele Promo, Ashton Hamme, Dale Spangler, Melvin Rueppel
  • Substituted polycyclic aryl and heteroaryl pyridones useful for selective inhibition of the coagulation cascade
    Publication number: 20050165062
    Abstract: The invention relates to substituted polycyclic aryl and heteroaryl pyridone compounds useful as inhibitors of serine proteases of the coagulation cascade and compounds, compositions and methods for anticoagulant therapy for the treatment and prevention of a variety of thrombotic conditions including coronary artery and cerebrovascular diseases.
    Type: Application
    Filed: December 10, 2004
    Publication date: July 28, 2005
    Applicant: Pharmacia Corporation
    Inventors: Michael South, Qingping Zeng, Ashton Hamme, Melvin Rueppel
  • Substituted polycyclic aryl and heteroaryl pyrimidinones useful for selective inhibition of the coagulation cascade
    Publication number: 20050054643
    Abstract: The invention relates to substituted polycyclic aryl and heteroaryl pyrimidinone compounds useful as inhibitors of serine proteases of the coagulation cascade and compounds, compositions and methods for anticoagulant therapy for the treatment and prevention of a variety of thrombotic conditions including coronary artery and cerebrovascular diseases.
    Type: Application
    Filed: October 7, 2003
    Publication date: March 10, 2005
    Inventors: Michael South, Ashton Hamme, William Neumann, Darin Jones, Melvin Rueppel
  • (R)-chiral halogenated substituted fused heterocyclic amino compounds useful for inhibiting cholesterol ester transfer protein activity
    Publication number: 20050043294
    Abstract: The invention relates to substituted aryl and heteroaryl (R)-Chiral Halogenated 1-Substitutedamino-(n+1)-Alkanol compounds useful as inhibitors of cholesteryl ester transfer protein (CETP; plasma lipid transfer protein-I) and compounds, compositions and methods for treating atherosclerosis and other coronary artery diseases. Novel high yield, stereoselective processes for the preparation of the chiral substituted alkanol compounds from chiral and achiral intermediates are described.
    Type: Application
    Filed: August 27, 2004
    Publication date: February 24, 2005
    Inventors: James Sikorski, Richard Durley, Margaret Grapperhaus, Mark Massa, Emily Reinhard, Yvette Fobian, Michael Tollefson, Lijuan Wang, Brian Hickory, Monica Norton, William Vernier, Deborah Mischke, Michele Promo, Ashton Hamme, Dale Spangler, Melvin Rueppel