Abstract: The present invention discloses compounds useful in treatment of conditions associated with dysfunction of ectonucleotide pyrophosphatase/phosphodiesterase-1 (ENPP1) enzyme. Specifically, the present invention discloses compound of formula (J) which exhibit inhibitory activity against ENPP1. Method of treating conditions associated with over-expression of ENPP1 gene with such compound is disclosed. Uses thereof, pharmaceutical composition, and kits are also disclosed.

Abstract: The present invention discloses compounds useful in treatment of conditions associated with dysfunction of ectonucleotide pyrophosphatase/phosphodiesterase-1 (ENPP1) enzyme. Specifically, the present invention discloses compound of formula (J) which exhibit inhibitory activity against ENPP1. Method of treating conditions associated with over-expression of ENPP1 gene with such compound is disclosed. Uses thereof, pharmaceutical composition, and kits are also disclosed.

Abstract: A fault indication from a fault source is to be provided to a demultiplexer which is configured to output the fault indication. The demultiplexer is configurable to output the fault indication to an OR gate of a plurality of OR gates coupled to a respective fault channel of a plurality of fault channels based on an application which uses the fault source as a resource. A reaction to the fault indication is performed based on the fault channel which received the fault indication.

Abstract: A fault indication from a fault source is to be provided to a demultiplexer which is configured to output the fault indication. The demultiplexer is configurable to output the fault indication to an OR gate of a plurality of OR gates coupled to a respective fault channel of a plurality of fault channels based on an application which uses the fault source as a resource. A reaction to the fault indication is performed based on the fault channel which received the fault indication.

Abstract: The present invention discloses compounds useful in treatment of conditions associated with dysfunction of ectonucleotide pyrophosphatase/phosphodiesterase-1 (ENPP1) enzyme. Specifically, the present invention discloses compound of formula (J) which exhibit inhibitory activity against ENPP1. Method of treating conditions associated with over-expression of ENPP1 gene with such compound is disclosed. Uses thereof, pharmaceutical composition, and kits are also disclosed.

Abstract: Heterocyclic compounds as Wee1 inhibitors are provided. The compounds may find use as therapeutic agents for the treatment of diseases and may find particular use in oncology.

Abstract: A mobile robot is configured for operation in a commercial or industrial setting, such as an office building or retail store. The mobile robot may include cameras for capturing images and videos and include microphones for capturing audio of its surroundings. To improve privacy by preventing confidential information from being transmitted, the mobile robot may detect text in images and modify the images to make the text illegible before transmitting the images. The mobile robot may also detect human voice in audio and modify audio to make the human voice unintelligible before transmitting the audio.

Abstract: The present invention generally discloses compounds having LXR (the liver X receptor) agonistic activity, to the use of such compounds in the treatment of various disorders such as proliferative disorders, Alzheimer's disease, inflammatory diseases, and diseases characterized by defects in cholesterol and lipid metabolism. Specifically, the present invention discloses compound of formula (IA) which exhibit LXR agonist activity, specifically to LXR?. The invention also discloses method of synthesis of said compounds, method of using said compounds, pharmaceutical compositions comprising said compounds and method of using thereof.

Abstract: The present invention discloses compounds useful in treatment of conditions associated with dysfunction of ectonucleotide pyrophosphatase/phosphodiesterase-1 (ENPP1) enzyme. Specifically, the present invention discloses compound of formula (J) which exhibit inhibitory activity against ENPP1. Method of treating conditions associated with over-expression of ENPP1 gene with such compound is disclosed. Uses thereof, pharmaceutical composition, and kits are also disclosed.

Abstract: Heterocyclic compounds as Wee1 inhibitors are provided. The compounds may find use as therapeutic agents for the treatment of diseases and may find particular use in oncology.

Abstract: Aspects of the present invention disclose a method, computer program product, and system for validation of services. The method includes one or more processors receiving a request of a service. The method further includes one or more processors parsing the received request of the service to identify information included in the received request of the service. The method further includes one or more processors generating a checklist that corresponds to the received request of the service based on the identified information, wherein the generated checklist includes configuration and security checks that are associated with the received request of the service. The method further includes one or more processors determining a validation result utilizing the generated checklist, wherein the validation result indicates whether the requested service is deployed on a corresponding endpoint according to the configuration and security checks in the generated checklist.

Abstract: A mobile robot is configured for operation in a commercial or industrial setting, such as an office building or retail store. The mobile robot may include cameras for capturing images and videos and include microphones for capturing audio of its surroundings. To improve privacy by preventing confidential information from being transmitted, the mobile robot may detect text in images and modify the images to make the text illegible before transmitting the images. The mobile robot may also detect human voice in audio and modify audio to make the human voice unintelligible before transmitting the audio.

Abstract: A multi-functional olefin copolymer viscosity index improver and a lubricating oil composition including such lubricant additive that provides improved viscometric properties and helps reduce low speed pre-ignition events at the same time. In one approach, the multi-functional olefin copolymer viscosity index improver is silicone functionalized and includes an acylated olefin copolymer with aminosilane or aminosiloxone pendant or side groups.

Abstract: Aspects of the present invention disclose a method, computer program product, and system for validation of services. The method includes one or more processors receiving a request of a service. The method further includes one or more processors parsing the received request of the service to identify information included in the received request of the service. The method further includes one or more processors generating a checklist that corresponds to the received request of the service based on the identified information, wherein the generated checklist includes configuration and security checks that are associated with the received request of the service. The method further includes one or more processors determining a validation result utilizing the generated checklist, wherein the validation result indicates whether the requested service is deployed on a corresponding endpoint according to the configuration and security checks in the generated checklist.

Abstract: Aspects of the present invention disclose a method, computer program product, and system for validation of services. The method includes one or more processors receiving a request of a service. The method further includes one or more processors parsing the received request of the service to identify information included in the received request of the service. The method further includes one or more processors generating a checklist that corresponds to the received request of the service based on the identified information, wherein the generated checklist includes configuration and security checks that are associated with the received request of the service. The method further includes one or more processors determining a validation result utilizing the generated checklist, wherein the validation result indicates whether the requested service is deployed on a corresponding endpoint according to the configuration and security checks in the generated checklist.

Abstract: Heterocyclic compounds as Wee1 inhibitors are provided. The compounds may find use as therapeutic agents for the treatment of diseases and may find particular use in oncology.

Abstract: Methods, systems, and computer program products for distributed iceberg cubing over ordered dimensions are provided herein. A method includes calculating, from input data derived from a search query, a set of multiple cube measures for one or more combinations of multiple non-ordered dimensions; pruning the set of multiple cube measures based on one or more iceberg conditions to generate a sub-set of the cube measures; and determining a range for a set of ordered dimensions over a distributed processing platform based on (i) the sub-set of the cube measures and (ii) the one or more iceberg conditions.

Abstract: Aspects of the present invention disclose a method, computer program product, and system for validation of services. The method includes one or more processors receiving a request of a service. The method further includes one or more processors parsing the received request of the service to identify information included in the received request of the service. The method further includes one or more processors generating a checklist that corresponds to the received request of the service based on the identified information, wherein the generated checklist includes configuration and security checks that are associated with the received request of the service. The method further includes one or more processors determining a validation result utilizing the generated checklist, wherein the validation result indicates whether the requested service is deployed on a corresponding endpoint according to the configuration and security checks in the generated checklist.

Abstract: Methods, systems, and computer program products for distributed iceberg cubing over ordered dimensions are provided herein. A method includes calculating, from input data derived from a search query, a set of multiple cube measures for one or more combinations of multiple non-ordered dimensions; pruning the set of multiple cube measures based on one or more iceberg conditions to generate a sub-set of the cube measures; and determining a range for a set of ordered dimensions over a distributed processing platform based on (i) the sub-set of the cube measures and (ii) the one or more iceberg conditions.

Abstract: A method of automating patching of a computer system includes determining whether a computer patch is available for a computer system of a customer, determining a patch management policy of the customer, determining a patch window of the customer based on the determined patch management policy, and directing application of the computer patch to the computer system at the determined patch window.