Patents by Inventor Ashu SHAH

Ashu SHAH has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • ANTI-PROPERDIN ANTIBODIES AND PREPARATION THEREOF
    Publication number: 20230054202
    Abstract: The present invention provides an antibody or antigen-binding portion thereof that can bind to properdin (factor P). The antibody of the current invention leads to selective inhibition of alternative complement pathway while allowing the classical and lectin pathways to continue. Further, the antibody of the present invention may have modified or reduced binding to Fc?Rs to minimize its ADCC activity. The present invention provide an antibody that comprises an amino acid sequence to minimise its CDC activity. The antibody according to the present invention has higher FcRn binding affinity and therefore the antibody according to the present invention may have long circulating half-life in the body of the patient and it can be given at a reduced dosing frequency. The antibody according to the present invention can further be used in the preparation of a drug for treating diseases through inhibition of alternative complement pathway.
    Type: Application
    Filed: January 8, 2021
    Publication date: February 23, 2023
    Inventors: Sanjeev Kumar MENDIRATTA, Arun SINGH, Ramkrashan KASERA, Aashini PARIKH, Jimit UPADHYAY, Pankaj KALITA, Dilip BANDYOPADHYAY, Ashu SHAH