Abstract: Disclosed herein are methods of diagnosing and treating MYC-driven cancers by detecting a PVT1 splice variant in a biological sample from a subject.

Abstract: Disclosed herein are methods of diagnosing and treating MYC-driven cancers by detecting a PVT1 splice variant in a biological sample from a subject.

Abstract: Described herein are methods and compositions for diagnosing, treating, or ameliorating symptoms of cancer, including MYC-driven and KRAS-driven cancer, with therapeutic HNB polypeptides. In some embodiments, disclosed herein are compositions comprising a synthetic nucleic acid sequence encoding a Plasmacytoma variant translocation 1_217 (PVT1_217) splice variant micropeptide, wherein the PVT1_217 splice variant micropeptide comprises at least 10 contiguous amino acids that are identical to a peptide encoded by a short open reading frame (shORF) located at the junction of Exon 3 and Exon 4 of human PVT 1_217.

Abstract: Provided herein are compositions comprising a vaccine composition and an agent that triggers metabolic reprogramming of B cells and methods of using the agent that triggers metabolic reprogramming of B cells to increase effectiveness of the vaccine by increasing memory B cell population. One aspect of the disclosure includes a method of increasing the effectiveness of a vaccine in a subject, which comprises administering a B cell metabolic reprogramming agent to the subject in a dose and schedule configured to increase the effectiveness of the vaccine, wherein the subject is administered with the vaccine.

Abstract: A thermoelectric material, having a formula TbxM1y-xM2zOw where M1 is one of Ca, Mg, Sr, Ba and Ra, M2 is at least one of Co, Fe, Ni, and Mn, x ranges from 0.01 to 5; y is 1, 2, 3, or 5; z is 1, 2, 3, or 4; and w is 1, 2, 3, 4, 5, 7, 8, 9, or 14. The thermoelectric material is chemically stable within 5% for one year and is also non-toxic. The thermoelectric material can also be incorporated into a thermoelectric system which can be used to generate electricity from waste heat sources or to cool an adjacent region.

Abstract: A system for providing mobile advertisement actions may include a memory to store a request, mobile carrier data, mobile advertisement data, and mobile advertisement action data. The system may include an interface operatively connected to the memory to communicate with a mobile device. The system may include a processor operatively connected to the memory and the interface. The processor may receive information and a request from the mobile device via the interface and may determine the mobile carrier data relating to a mobile carrier associated with the mobile device. The processor may identify the mobile advertisement data and the mobile advertisement action targeted to the request and the mobile carrier data. The processor may append the mobile advertisement action data to the mobile advertisement data. The processor may provide the mobile advertisement data with the appended mobile advertisement action data to the mobile device via the interface.

Abstract: A thermoelectric material, having a formula TbxM1y-xM2zOw where M1 is one of Ca, Mg, Sr, Ba and Ra, M2 is at least one of Co, Fe, Ni, and Mn, x ranges from 0.01 to 5; y is 1, 2, 3, or 5; z is 1, 2, 3, or 4; and w is 1, 2, 3, 4, 5, 7, 8, 9, or 14. The thermoelectric material is chemically stable within 5% for one year and is also non-toxic. The thermoelectric material can also be incorporated into a thermoelectric system which can be used to generate electricity from waste heat sources or to cool an adjacent region.

Abstract: A system for providing mobile advertisement actions may include a memory to store a request, mobile carrier data, mobile advertisement data, and mobile advertisement action data. The system may include an interface operatively connected to the memory to communicate with a mobile device. The system may include a processor operatively connected to the memory and the interface. The processor may receive information and a request from the mobile device via the interface and may determine the mobile carrier data relating to a mobile carrier associated with the mobile device. The processor may identify the mobile advertisement data and the mobile advertisement action targeted to the request and the mobile carrier data. The processor may append the mobile advertisement action data to the mobile advertisement data. The processor may provide the mobile advertisement data with the appended mobile advertisement action data to the mobile device via the interface.

Abstract: A system for providing mobile advertisement actions may include a memory to store a request, mobile carrier data, mobile advertisement data, and mobile advertisement action data. The system may include an interface operatively connected to the memory to communicate with a mobile device. The system may include a processor operatively connected to the memory and the interface. The processor may receive information and a request from the mobile device via the interface and may determine the mobile carrier data relating to a mobile carrier associated with the mobile device. The processor may identify the mobile advertisement data and the mobile advertisement action targeted to the request and the mobile carrier data. The processor may append the mobile advertisement action data to the mobile advertisement data. The processor may provide the mobile advertisement data with the appended mobile advertisement action data to the mobile device via the interface.

Abstract: This invention relates to a high affinity recombinant humanized antibody fragment (scFv) specific for hepatitis B surface antigen having unique inter/intra chain bonding interaction because of 28 altered amino acid residues from the original mouse (5S) antibody and its chimeric Fab form, wherein fine tuning of the vernier zone residue makes it closer to the human sequence without any structural constraints.

Abstract: Nanostructured films including a plurality of nanowells, the nanowells having a pore at the top surface of the film, the pore defining a channel that extends downwardly towards the bottom surface of the film are provided. Also provided are methods including exposing a growth substrate to an anodizing bath, applying ultrasonic vibrations to the anodizing bath, and generating a current through the anodizing bath to form the nanostructured film. The nanostructured films may be formed from TiO2 and may be used to provide solid state dye sensitized solar cells having high conversion efficiencies.

Abstract: An integrated circuit (IC) includes a plurality of input/output (I/O) terminals through which signals pass into or out of the IC and an I/O timing module. The I/O timing module is configured to add propagation delay to signals passing between the I/O terminals and I/O subsystems of the IC. The I/O timing module includes a plurality of delay elements associated with each of the I/O terminals, a control register associated with each of the I/O terminals, a memory, and I/O delay control logic. The control register is coupled to each of the delay elements associated with the I/O terminal. The memory is encoded with delay information. The I/O delay control logic is configured to initialize the propagation delay associated with each of the I/O terminals by selecting which of the delay elements are to be applied to produce the propagation delay based on the delay information stored in the memory.

Abstract: An integrated circuit (IC) includes a plurality of input/output (I/O) terminals through which signals pass into or out of the IC and an I/O timing module. The I/O timing module is configured to add propagation delay to signals passing between the I/O terminals and I/O subsystems of the IC. The I/O timing module includes a plurality of delay elements associated with each of the I/O terminals, a control register associated with each of the I/O terminals, a memory, and I/O delay control logic. The control register is coupled to each of the delay elements associated with the I/O terminal. The memory is encoded with delay information. The I/O delay control logic is configured to initialize the propagation delay associated with each of the I/O terminals by selecting which of the delay elements are to be applied to produce the propagation delay based on the delay information stored in the memory.

Abstract: A system is disclosed for detecting and handling click fraud in a mobile environment. The system may identify a source of a request. The request may be handled differently based on whether the source of the request originated from mobile traffic or web traffic. The source of the request may be used to determine whether a request is valid or invalid. The request may be flagged if the request is invalid.

Abstract: A system is disclosed for detecting and handling click fraud in a mobile environment. The system may identify a source of a request. The request may be handled differently based on whether the source of the request originated from mobile traffic or web traffic. The source of the request may be used to determine whether a request is valid or invalid. The request may be flagged if the request is invalid.

Abstract: An apparatus adapts a pre-designed circuit module not supporting a power management protocol to a power management protocol. The apparatus disconnects a bus interface, disables interrupt and stops a clock to the pre-designed circuit module on a external idle request signal.

Abstract: A system for providing mobile advertisement actions may include a memory to store a request, mobile carrier data, mobile advertisement data, and mobile advertisement action data. The system may include an interface operatively connected to the memory to communicate with a mobile device. The system may include a processor operatively connected to the memory and the interface. The processor may receive information and a request from the mobile device via the interface and may determine the mobile carrier data relating to a mobile carrier associated with the mobile device. The processor may identify the mobile advertisement data and the mobile advertisement action targeted to the request and the mobile carrier data. The processor may append the mobile advertisement action data to the mobile advertisement data. The processor may provide the mobile advertisement data with the appended mobile advertisement action data to the mobile device via the interface.

Abstract: A system for providing mobile advertisement actions may include a memory to store a request, mobile carrier data, mobile advertisement data, and mobile advertisement action data. The system may include an interface operatively connected to the memory to communicate with a mobile device. The system may include a processor operatively connected to the memory and the interface. The processor may receive information and a request from the mobile device via the interface and may determine the mobile carrier data relating to a mobile carrier associated with the mobile device. The processor may identify the mobile advertisement data and the mobile advertisement action targeted to the request and the mobile carrier data. The processor may append the mobile advertisement action data to the mobile advertisement data. The processor may provide the mobile advertisement data with the appended mobile advertisement action data to the mobile device via the interface.

Abstract: Nanostructured films including a plurality of nanowells, the nanowells having a pore at the top surface of the film, the pore defining a channel that extends downwardly towards the bottom surface of the film are provided. Also provided are methods including exposing a growth substrate to an anodizing bath, applying ultrasonic vibrations to the anodizing bath, and generating a current through the anodizing bath to form the nanostructured film. The nanostructured films may be formed from TiO2 and may be used to provide solid state dye sensitized solar cells having high conversion efficiencies.

Abstract: Provided herein are PIN structures including a layer of amorphous n-type silicon, a layer of intrinsic GaAs disposed over the layer of amorphous n-type silicon, and a layer of amorphous p-type silicon disposed over the layer of intrinsic GaAs. The layer of intrinsic GaAs may be engineered by the disclosed methods to exhibit a variety of structural properties that enhance light absorption and charge carrier mobility, including oriented polycrystalline intrinsic GaAs, embedded particles of intrinsic GaAs, and textured surfaces. Also provided are devices incorporating the PIN structures, including photovoltaic devices.