Patents by Inventor Ashvani K. Singh

Ashvani K. Singh has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS
    Publication number: 20160228414
    Abstract: The present invention relates to modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including CF Transmembrane Regulator (“CFTR”), compositions thereof, and methods therewith. The present invention also relates to methods of treating ABC transporter mediated diseases using such modulators.
    Type: Application
    Filed: January 29, 2016
    Publication date: August 11, 2016
    Inventors: Sara S. Hadida Ruah, Mark T. Miller, Ashvani K. Singh, Thomas Cleveland, Lewis R. Makings, Matthew Hamilton, Peter D.J. Grootenhuis
  • Modulators of ATP-binding cassette transporters
    Patent number: 9249131
    Abstract: The present invention relates to modulator of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including CF Transmembrane Regulator (“CFTR”), compositions thereof, and methods therewith. The present invention also relates to methods of treating ABC transporter mediated diseases using such modulators.
    Type: Grant
    Filed: October 6, 2014
    Date of Patent: February 2, 2016
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Sara S. Hadida Ruah, Mark T. Miller, Ashvani K. Singh, Thomas Cleveland, Lewis R. Makings, Matthew Hamilton, Peter D. J. Grootenhuis
  • COMPOUNDS USEFUL IN CFTR ASSAYS AND METHODS THEREWITH
    Publication number: 20150293078
    Abstract: The present invention relates to compounds useful in CFTR assays. The present invention also relates to compounds useful in monitoring CFTR activity in therapies for CFTR-mediated diseases. The present invention also provides an assay for use in measuring CFTR correction.
    Type: Application
    Filed: April 17, 2015
    Publication date: October 15, 2015
    Inventors: Ashvani K. Singh, Fredrick F. Van Goor, Jennings Franklin Worley, III, Thomas Knapp
  • MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS
    Publication number: 20150025076
    Abstract: The present invention relates to modulator of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including CF Transmembrane Regulator (“CFTR”), compositions thereof, and methods therewith. The present invention also relates to methods of treating ABC transporter mediated diseases using such modulators.
    Type: Application
    Filed: October 6, 2014
    Publication date: January 22, 2015
    Inventors: Sara S. Hadida Ruah, Mark T. Miller, Ashvani K. Singh, Thomas Cleveland, Lewis R. Makings, Matthew Hamilton, Peter D.J. Grootenhuis
  • Multiwell assay apparatus and method for determining biological activity of compounds
    Patent number: 8852881
    Abstract: A device for characterizing the biological properties of cells can include a plurality of dual-compartment assay chambers wherein the compartments of each chamber are separated by a cell layer across which ions can flow. The biological properties of the cell layer in the presence or absence of experimental compounds can be determined by measuring an electrical gradient across the layer. A individual dual-compartment chamber of this type may be referred to as an “Ussing chamber.
    Type: Grant
    Filed: November 29, 2006
    Date of Patent: October 7, 2014
    Assignee: Vertex Pharmaceuticals, Inc.
    Inventors: Paul A. Negulescu, Alec T. Harootunian, Philip E. Salzmann, Javier H. Flores, James E. Sinclair, Minh Vuong, Ashvani K. Singh, Fred F. VanGoor
  • Modulators of ATP-binding cassette transporters
    Patent number: 8853415
    Abstract: The present invention relates to modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including CF Transmembrane Regulator (“CFTR”), compositions thereof, and methods therewith. The present invention also relates to methods of treating ABC transporter mediated diseases using such modulators.
    Type: Grant
    Filed: November 14, 2013
    Date of Patent: October 7, 2014
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Sara S. Hadida Ruah, Mark T. Miller, Ashvani K. Singh, Thomas Cleveland, Lewis R. Makings, Matthew Hamilton, Peter D. J. Grootenhuis
  • Modulators of ATP-binding cassette transporters
    Patent number: 8741939
    Abstract: The present invention relates to modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including CF Transmembrane Regulator (“CFTR”), compositions thereof, and methods therewith. The present invention also relates to methods of treating ABC transporter mediated diseases using such modulators.
    Type: Grant
    Filed: March 22, 2013
    Date of Patent: June 3, 2014
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Sara S. Hadida Ruah, Mark T. Miller, Ashvani K. Singh, Thomas Cleveland, Lewis R. Makings, Matthew Hamilton, Peter D. J. Grootenhuis
  • Modulators of ATP-Binding Cassette Transporters
    Publication number: 20140072995
    Abstract: The present invention relates to modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including CF Transmembrane Regulator (“CFTR”), compositions thereof, and methods therewith. The present invention also relates to methods of treating ABC transporter mediated diseases using such modulators.
    Type: Application
    Filed: November 14, 2013
    Publication date: March 13, 2014
    Applicant: Vertex Pharmaceuticals Incorporated
    Inventors: Sara S. Hadida Ruah, Mark T. Miller, Ashvani K. Singh, Thomas Cleveland, Lewis R. Makings, Matthew Hamilton, Peter D.J. Grootenhuis
  • Modulators of ATP-Binding Cassette Transporters
    Publication number: 20130252333
    Abstract: The present invention relates to modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including CF Transmembrane Regulator (“CFTR”), compositions thereof, and methods therewith. The present invention also relates to methods of treating ABC transporter mediated diseases using such modulators.
    Type: Application
    Filed: March 22, 2013
    Publication date: September 26, 2013
    Inventors: Sara S. Hadida Ruah, Mark T. Miller, Ashvani K. Singh, Thomas Cleveland, Lewis R. Makings, Matthew Hamilton, Peter D.J. Grootenhuis
  • Modulators of ATP-binding cassette transporters
    Patent number: 8431605
    Abstract: The present invention relates to modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including CF Transmembrane Regulator (“CFTR”), compositions thereof, and methods therewith. The present invention also relates to methods of treating ABC transporter mediated diseases using such modulators.
    Type: Grant
    Filed: July 1, 2011
    Date of Patent: April 30, 2013
    Assignee: Vertex Pharmaceutical Incorporated
    Inventors: Sara S. Hadida Ruah, Mark T. Miller, Ashvani K. Singh, Thomas Cleveland, Lewis R. Makings, Matthew Hamilton, Peter D. J. Grootenhuis
  • MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS
    Publication number: 20120004216
    Abstract: The present invention relates to modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including CF Transmembrane Regulator (“CFTR”), compositions thereof, and methods therewith. The present invention also relates to methods of treating ABC transporter mediated diseases using such modulators.
    Type: Application
    Filed: July 1, 2011
    Publication date: January 5, 2012
    Applicant: VERTEX PHARMACEUTICALS INCORPORATED
    Inventors: Sara S. Hadida Ruah, Mark T. Miller, Ashvani K. Singh, Thomas Cleveland, Lewis R. Makings, Matthew Hamilton, Peter D.J. Grootenhuis
  • Modulators of ATP-Binding Cassette transporters
    Patent number: 7973169
    Abstract: The present invention relates to modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including CF Transmembrane Regulator (“CFTR”), compositions thereof, and methods therewith. The present invention also relates to methods of treating ABC transporter mediated diseases using such modulators.
    Type: Grant
    Filed: September 7, 2004
    Date of Patent: July 5, 2011
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Sara S. Hadida Ruah, Mark T. Miller, Ashvani K. Singh, Thomas Cleveland, Lewis R. Makings, Matthew Hamilton, Peter D. J. Grootenhuis
  • Modulators of ATP-binding cassette transporters
    Patent number: 7598412
    Abstract: The present invention provides compounds of Formula I useful as modulators of ABC transporter activity, or a pharmaceutically acceptable salt thereof, wherein RB, n, B, RC, RD, RE, A, and Z are described generally and in classes and subclasses below. The present invention also provides pharmaceutical compositions, methods and kits associated with Formula I, useful for as modulators, and for the treatments of disease and disease conditions associated with ABC transporter proteins.
    Type: Grant
    Filed: October 8, 2004
    Date of Patent: October 6, 2009
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Sara S. Hadida Ruah, Ashvani K. Singh, Mark T. Miller, Matthew Hamilton, Peter D. J. Grootenhuis
  • COMPOUNDS USEFUL IN CFTR ASSAYS AND METHODS THEREWITH
    Publication number: 20090246820
    Abstract: The present invention relates to compounds useful in CFTR assays. The present invention also relates to compounds useful in monitoring CFTR activity in therapies for CFTR-mediated diseases. The present invention also provides an assay for use in measuring CFTR correction.
    Type: Application
    Filed: June 27, 2008
    Publication date: October 1, 2009
    Inventors: Ashvani K. Singh, Fredrick F. Van Goor, Jennings Franklin Worley, III, Thomas Knapp
  • Multiwell plate assembly for use in high throughput assays
    Patent number: 7169609
    Abstract: A device for characterizing the biological properties of cells can include a plurality of dual-compartment assay chambers wherein the compartments of each chamber are separated by a cell layer across which ions can flow. The biological properties of the cell layer in the presence or absence of experimental compounds can be determined by measuring an electrical gradient across the layer. A individual dual-compartment chamber of this type may be referred to as an “Ussing chamber.
    Type: Grant
    Filed: March 31, 2004
    Date of Patent: January 30, 2007
    Assignee: Vertex Pharmaceutcals, Inc.
    Inventors: Paul A. Negulescu, Alec T. Harootunian, Philip E. Salzmann, Javier H. Flores, James E. Sinclair, Minh Vuong, Ashvani K. Singh, Fred F. VanGoor
  • Calixarene chloride-channel blockers
    Patent number: 5489612
    Abstract: Calixarene derivatives, their synthesis and use as chloride channel blockers are described. Preferred calixarene derivatives are of the formula: ##STR1## wherein R is an acidic group or salt thereof, such as SO.sub.3 X or R.sup.1 SO.sub.3 X where X is H or Na, and R.sup.1 is ##STR2## where m=1-2, and R.sup.3 and R.sup.4 the same or different is each H or a C.sub.1-4 alkyl, or a nitrogen-containing group of the formula ##STR3## or A, wherein R.sup.5 is a C.sub.1-4 alkyl, R.sup.6 is a C.sub.1-4 alkyl and A is ##STR4## where R.sup.7 and R.sup.8, the same or different each is H or a C.sub.1-4 alkyl, and R.sup.9 and R.sup.10, the same or different, each is H or a C.sub.1-4 alkyl; R' is H or a C.sub.1-4 alkyl; and n is an integer of 4-8, preferably 4, 6 or 8.
    Type: Grant
    Filed: January 7, 1994
    Date of Patent: February 6, 1996
    Assignee: The University of Alabama at Birmingham Research Foundation
    Inventors: Jerry L. Atwood, Robert J. Bridges, Ravindra K. Juneja, Ashvani K. Singh