Patents by Inventor Ashvani Singh

Ashvani Singh has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Modulators of ATP-binding cassette transporters
    Patent number: 8101767
    Abstract: The present invention relates to modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator, compositions thereof, and methods therewith. The present invention also relates to methods of treating ABC transporter mediated diseases using such modulators.
    Type: Grant
    Filed: January 9, 2009
    Date of Patent: January 24, 2012
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Sara Hadida Ruah, Anna Hazlewood, Peter D. J. Grootenhuis, Fredrick Van Goor, Ashvani Singh, Jinglan Zhou, Jason McCartney
  • Therapeutic Combinations Useful in Treating CFTR Related Diseases
    Publication number: 20110177999
    Abstract: The present invention relates to therapeutic combinations and kits useful in treating CFTR-related diseases, such as cystic fibrosis.
    Type: Application
    Filed: August 7, 2008
    Publication date: July 21, 2011
    Inventors: Ashvani Singh, Jennings Franklin Worley, Gregor Zlokamik
  • Modulators of ATP-Binding Cassette Transporters
    Publication number: 20100125090
    Abstract: The present invention provides compounds of Formula I useful as modulators of ABC transporter activity, or a pharmaceutically acceptable salt thereof, wherein RB, n, B, RC, RD, RE, A, and Z are described generally and in classes and subclasses below. The present invention also provides pharmaceutical compositions, methods and kits associated with Formula I, useful for as modulators, and for the treatments of disease and disease conditions associated with ABC transporter proteins.
    Type: Application
    Filed: August 14, 2009
    Publication date: May 20, 2010
    Applicant: VERTEX PHARMACEUTICALS INCORPORATED
    Inventors: Sara S. Hadida Ruah, Mark Miller, Ashvani Singh, Matthew Hamilton, Peter D.J. Grootenhuis
  • MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS
    Publication number: 20090298876
    Abstract: The present invention relates to modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator, compositions thereof, and methods therewith. The present invention also relates to methods of treating ABC transporter mediated diseases using such modulators.
    Type: Application
    Filed: January 9, 2009
    Publication date: December 3, 2009
    Applicant: VERTEX PHARMACEUTICALS INCORPORATED
    Inventors: Sara Hadida Ruah, Anna Hazlewood, Peter D.J. Grootenhuis, Fredrick Van Goor, Ashvani Singh, Jinglan Zhou, Jason McCartney
  • MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS
    Publication number: 20090227797
    Abstract: The present invention relates to modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator, compositions thereof, and methods therewith. The present invention also relates to methods of treating ABC transporter mediated diseases using such modulators.
    Type: Application
    Filed: January 9, 2009
    Publication date: September 10, 2009
    Applicant: Vertex Pharmaceuticals Incorporated
    Inventors: Sara Hadida Ruah, Anna Hazlewood, Peter D.J. Grootenhuis, Fredrick Van Goor, Ashvani Singh, Jinglan Zhou, Jason McCartney
  • Modulators of ATP-binding cassette transporters
    Patent number: 7495103
    Abstract: The present invention relates to modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator, compositions thereof, and methods therewith. The present invention also relates to methods of treating ABC transporter mediated diseases using such modulators.
    Type: Grant
    Filed: June 24, 2005
    Date of Patent: February 24, 2009
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Sara Hadida-Ruah, Anna Hazelwood, Peter Grootenhuis, Fred Van Goor, Ashvani Singh, Jinglan Zhou, Jason McCartney
  • Modulators of ATP-Binding Cassette Transporters
    Publication number: 20080071095
    Abstract: The present invention relates to modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator, compositions thereof, and methods therewith. The present invention also relates to methods of treating ABC transporter mediated diseases using such modulators.
    Type: Application
    Filed: August 20, 2007
    Publication date: March 20, 2008
    Applicant: Vertex Pharmaceuticals Incorporated
    Inventors: Sara Hadida-Ruah, Anna Hazelwood, Peter Grootenhuis, Fred Van Goor, Ashvani Singh, Jinglan Zhou, Jason McCartney
  • Modulators of ATP-binding cassette transporters
    Publication number: 20070105833
    Abstract: 4-amido-pyrimidine compounds, derivatives and compositions thereof, and synthetic methods described herein are useful for modulating ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator (“CFTR”). The present invention also relates to methods of treating ABC transporter mediated diseases using such modulators.
    Type: Application
    Filed: May 22, 2006
    Publication date: May 10, 2007
    Inventors: Sara Ruah, Anna Hazlewood, Peter Grootenhuis, Ashvani Singh, Thomas Cleveland, Frederick Van-Goor
  • Multiwell plate assembly for use in high throughput assays
    Publication number: 20070072257
    Abstract: A device for characterizing the biological properties of cells can include a plurality of dual-compartment assay chambers wherein the compartments of each chamber are separated by a cell layer across which ions can flow. The biological properties of the cell layer in the presence or absence of experimental compounds can be determined by measuring an electrical gradient across the layer. A individual dual-compartment chamber of this type may be referred to as an “Ussing chamber.
    Type: Application
    Filed: November 29, 2006
    Publication date: March 29, 2007
    Inventors: Paul Negulescu, Alec Harootunian, Philip Salzmann, Javier Flores, James Sinclair, Minh Vuong, Ashvani Singh, Fred VanGoor
  • Modulators of ATP-binding cassette transporters
    Publication number: 20060074075
    Abstract: The present invention relates to modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator, compositions thereof, and methods therewith. The present invention also relates to methods of treating ABC transporter mediated diseases using such modulators.
    Type: Application
    Filed: June 24, 2005
    Publication date: April 6, 2006
    Inventors: Sara Hadida-Ruah, Anna Hazelwood, Peter Grootenhuis, Fred Goor, Ashvani Singh, Jinglan Zhou, Jason McCartney
  • Multiwell plate assembly for use in high throughput assays
    Publication number: 20050221274
    Abstract: A device for characterizing the biological properties of cells can include a plurality of dual-compartment assay chambers wherein the compartments of each chamber are separated by a cell layer across which ions can flow. The biological properties of the cell layer in the presence or absence of experimental compounds can be determined by measuring an electrical gradient across the layer. A individual dual-compartment chamber of this type may be referred to as an “Ussing chamber.
    Type: Application
    Filed: March 31, 2004
    Publication date: October 6, 2005
    Inventors: Paul Negulescu, Alec Harootunian, Philip Salzmann, Javier Flores, James Sinclair, Minh Vuong, Ashvani Singh, Fred VanGoor
  • Modulators of ATP-Binding Cassette transporters
    Publication number: 20050176789
    Abstract: The present invention relates to modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including CF Transmembrane Regulator (“CFTR”), compositions thereof, and methods therewith. The present invention also relates to methods of treating ABC transporter mediated diseases using such modulators.
    Type: Application
    Filed: September 7, 2004
    Publication date: August 11, 2005
    Inventors: Sara Hadida Ruah, Mark Miller, Ashvani Singh, Thomas Cleveland, Lewis Makings, Matthew Hamilton, Peter Grootenhuis
  • Modulators of ATP-binding cassette transporters
    Publication number: 20050148648
    Abstract: The present invention provides compounds of Formula I useful as modulators of ABC transporter activity, or a pharmaceutically acceptable salt thereof, wherein RB, n, B, RC, RD, RE, A, and Z are described generally and in classes and subclasses below. The present invention also provides pharmaceutical compositions, methods and kits associated with Formula I, useful for as modulators, and for the treatments of disease and disease conditions associated with ABC transporter proteins.
    Type: Application
    Filed: October 8, 2004
    Publication date: July 7, 2005
    Inventors: Sara Hadida Ruah, Ashvani Singh, Mark Miller, Matthew Hamilton, Peter Grootenhuis
  • Modulators of ATP-binding cassette transporters
    Publication number: 20050113423
    Abstract: The present invention relates to modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Regulator (“CFTR”), compositions thereof, and methods therewith. The present invention also relates to methods of treating ABC transporter mediated diseases using such modulators.
    Type: Application
    Filed: March 12, 2004
    Publication date: May 26, 2005
    Inventors: Frederick VanGoor, Sara Ruah, Ashvani Singh, Eric Olson, Lewis Makings, Jesus Gonzalez, James Rader, Fred Chambers, Mark Miller, Peter Grootenhuis, Yahua Liu