Abstract: Methods for assessing steatosis and fibrosis in a patient's liver include (i) measuring a diffusion-weighted relaxometry signal of the liver, or portion thereof; and determining a fibrosis content of the liver or portion thereof based on the measured diffusion-weighted relaxometry signal, or (ii) measuring a relaxometry signal of the liver, or portion thereof; and determining a fat content of the liver or portion thereof based on the measured relaxometry signal. A system for such non-invasive sensing includes a static magnetic field source; RF transmitter coils connected to a pulse sequence generator; RF receiver coils configured to detect a magnetic field generated within liver tissues; and a signal acquisition and processor system configured to acquire signals from the RF receiver coils and perform a relaxation time (T2) relaxometry measurement, wherein the RF transmitter coils and pulse sequence generator are configured to apply a varying magnetic field to the liver tissues.

Abstract: Devices and methods are provided for non-invasive sensing of tissue fluid distribution in a patient. The device includes one or more magnets configured to provide a static magnetic field source; one or more RF transmitter coils connected to a pulse sequence generator which are configured to apply a varying magnetic field to tissues of the patient; one or more RF receiver coils configured to detect a magnetic field generated within tissues of the patient; and a signal acquisition and processor system configured to acquire signals from the RF receiver coils and perform an NMR measurement of a relaxation parameter of hydrogen nuclei within a muscle tissue site of the patient. A single-sided MR sensor device may include permanent magnets arranged in a unilateral linear Halbach array; and RF coils and a processor which are configured to produce a depth-resolved, diffusion-weighted, multicomponent T2 relaxometry measurements of intramuscular fluid shifts in a patient.

Abstract: Devices and methods are provided for non-invasive sensing of tissue fluid distribution in a patient. The device includes one or more magnets configured to provide a static magnetic field source; one or more RF transmitter coils connected to a pulse sequence generator which are configured to apply a varying magnetic field to tissues of the patient; one or more RF receiver coils configured to detect a magnetic field generated within tissues of the patient; and a signal acquisition and processor system configured to acquire signals from the RF receiver coils and perform an NMR measurement of a relaxation parameter of hydrogen nuclei within a muscle tissue site of the patient. A single-sided MR sensor device may include permanent magnets arranged in a unilateral linear Halbach array; and RF coils and a processor which are configured to produce a depth-resolved, diffusion-weighted, multicomponent T2 relaxometry measurements of intramuscular fluid shifts in a patient.

Abstract: Methods for assessing steatosis and fibrosis in a patient's liver include (i) measuring a diffusion-weighted relaxometry signal of the liver, or portion thereof; and determining a fibrosis content of the liver or portion thereof based on the measured diffusion-weighted relaxometry signal, or (ii) measuring a relaxometry signal of the liver, or portion thereof; and determining a fat content of the liver or portion thereof based on the measured relaxometry signal. A system for such non-invasive sensing includes a static magnetic field source; RF transmitter coils connected to a pulse sequence generator; RF receiver coils configured to detect a magnetic field generated within liver tissues; and a signal acquisition and processor system configured to acquire signals from the RF receiver coils and perform a relaxation time (T2) relaxometry measurement, wherein the RF transmitter coils and pulse sequence generator are configured to apply a varying magnetic field to the liver tissues.

Abstract: A Unilateral Linear Halbach magnet configuration includes a central magnetized region recessed relative to adjacent magnetized regions disposed on opposite sides of the central magnetized region. The Unilateral Linear Halbach magnet configuration further includes side (or outer) magnetized regions disposed adjacent the center-adjacent magnetized regions. The center and center-adjacent magnetized regions have like-pointing magnetization vectors while the magnetization vectors of the side magnetized regions point in directions orthogonal to the magnetization vectors of the center and center-adjacent regions. Further, the magnetization vectors of the side magnetized regions point in opposite directions.

Abstract: A Unilateral Linear Halbach magnet configuration includes a central magnetized region recessed relative to adjacent magnetized regions disposed on opposite sides of the central magnetized region. The Unilateral Linear Halbach magnet configuration further includes side (or outer) magnetized regions disposed adjacent the center-adjacent magnetized regions. The center and center-adjacent magnetized regions have like-pointing magnetization vectors while the magnetization vectors of the side magnetized regions point in directions orthogonal to the magnetization vectors of the center and center-adjacent regions. Further, the magnetization vectors of the side magnetized regions point in opposite directions.