Patents by Inventor Ashwani Kumar Verma
Ashwani Kumar Verma has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10174035Abstract: The present invention relates to a pyrazole derivative of formula (I), a pharmaceutically acceptable salt thereof, a prodrug thereof, a hydrate thereof, stereoisomer thereof or a deuterium form thereof, wherein, n, Y, Ra, R1, R2, R3, R4, R5 and R6 are as defined hereinafter in the specification, a pharmaceutical composition comprising a compound of formula (I) as an active ingredient, methods of production, and methods of use thereof. Particularly, the present invention provides a compound of formula (I) as inhibitors of phosphatidylinositol-3-kinase (PI3K), which can be used for treating or preventing inflammatory, autoimmune, orphan and hyperproliferative disease and disorder.Type: GrantFiled: March 29, 2016Date of Patent: January 8, 2019Assignee: Daiichi Sankyo Company, LimitedInventors: Kirandeep Kaur Samby, Yogesh Baban Surase, Sagar Ramdas Amale, Suresh Kumar Gorla, Priyanka Patel, Ashwani Kumar Verma
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Publication number: 20180072732Abstract: The present invention relates to a pyrazole derivative of formula (I), a pharmaceutically acceptable salt thereof, a prodrug thereof, a hydrate thereof, stereoisomer thereof or a deuterium form thereof, wherein, n, Y, Ra, R1, R2, R3, R4, R5 and R6 are as defined hereinafter in the specification, a pharmaceutical composition comprising a compound of formula (I) as an active ingredient, methods of production, and methods of use thereof. Particularly, the present invention provides a compound of formula (I) as inhibitors of phosphatidylinositol-3-kinase (PI3K), which can be used for treating or preventing inflammatory, autoimmune, orphan and hyperproliferative disease and disorder.Type: ApplicationFiled: March 29, 2016Publication date: March 15, 2018Applicant: Daiichi Sankyo Company, LimitedInventors: Kirandeep Kaur Samby, Yogesh Baban Surase, Sagar Ramdas Amale, Suresh Kumar Gorla, Priyanka Patel, Ashwani Kumar Verma
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Patent number: 9509694Abstract: A method for parallel authentication comprises receiving a download request from a client computer system to download a document stored in a first storage system. The first storage system is coupled to the client computer system via a network. The first storage system is coupled with a second storage system via the network. The download request includes a first token associated with the first storage system and a second token associated with the second storage system. The first storage system is configured to authenticate the download request based on the first token and the second token. Based on successful authentication, the first storage system is configured to authorize the client computer system to download the document.Type: GrantFiled: December 31, 2013Date of Patent: November 29, 2016Assignee: EMC IP HOLDING COMPANY LLCInventors: Varun Parmar, Ondrej Hrebicek, Matthew Doermann, Brian W. Levine, Ashwani Kumar Verma, Alex Kronrod
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Patent number: 9364466Abstract: The present invention provides a heterocyclic compound of formula (I), a pharmaceutically acceptable salt thereof, a prodrug thereof or a hydrate thereof, wherein A, A? B, D, R1, R2 and R3 are as defined herein, a pharmaceutical composition comprising a compound of formula (I) as an active ingredient, methods of production, and methods of use thereof. Particularly, the present invention provides a compound of formula (I) useful for treating or preventing a disease, condition or disorder associated with protein kinases, preferably Janus Kinase family.Type: GrantFiled: February 13, 2015Date of Patent: June 14, 2016Assignee: Daiichi Sankyo Company, LimitedInventors: Ashwani Kumar Verma, Kumaragurubaran Nagaswamy, Lalima Sharma, Soma Ghosh, Balkrishna Ramchandra Kale, Aniruddha Mondal, Punit Kumar Srivastava, Sunanda Ghosh Dastidar, Rijwan Jaffer Momin, Pradip Balu Wagh, Sonali Nanasaheb Pansare, Pramod Raosaheb Markad, Yogesh Balasaheb Khairnar, Rie Miyauchi, Takeshi Murata, Masayuki Ishizaki, Masatoshi Nagamochi, Shin Iimura
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Publication number: 20150188922Abstract: A method for parallel authentication comprises receiving a download request from a client computer system to download a document stored in a first storage system. The first storage system is coupled to the client computer system via a network. The first storage system is coupled with a second storage system via the network. The download request includes a first token associated with the first storage system and a second token associated with the second storage system. The first storage system is configured to authenticate the download request based on the first token and the second token. Based on successful authentication, the first storage system is configured to authorize the client computer system to download the document.Type: ApplicationFiled: December 31, 2013Publication date: July 2, 2015Applicant: EMC CorporationInventors: Varun Parmar, Ondrej Hrebicek, Matthew Doermann, Brian W. Levine, Ashwani Kumar Verma, Alex Kronrod
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Publication number: 20150157613Abstract: The present invention provides a heterocyclic compound of formula (I), a pharmaceutically acceptable salt thereof, a prodrug thereof or a hydrate thereof, wherein A, A? B, D, R1, R2 and R3 are as defined herein, a pharmaceutical composition comprising a compound of formula (I) as an active ingredient, methods of production, and methods of use thereof. Particularly, the present invention provides a compound of formula (I) useful for treating or preventing a disease, condition or disorder associated with protein kinases, preferably Janus Kinase family.Type: ApplicationFiled: February 13, 2015Publication date: June 11, 2015Applicant: DAIICHI SANKYO COMPANY, LIMITEDInventors: Ashwani Kumar Verma, Kumaragurubaran Nagaswamy, Lalima Sharma, Soma Ghosh, Balkrishna Ramchandra Kale, Aniruddha Mondal, Punit Kumar Srivastava, Sunanda Ghosh Dastidar, Rijwan Jaffer Momin, Pradip Balu Wagh, Sonali Nanasaheb Pansare, Pramod Raosaheb Markad, Yogesh Balasaheb Khairnar, Rie Miyauchi, Takeshi Murata, Masayuki Ishizaki, Masatoshi Nagamochi, Shin Iimura
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Patent number: 8980911Abstract: The present invention provides a heterocyclic compound of formula (I), a pharmaceutically acceptable salt thereof, a prodrug thereof or a hydrate thereof, wherein A, A? B, D, R1, R2 and R3 are as defined herein, a pharmaceutical composition comprising a compound of formula (I) as an active ingredient, methods of production, and methods of use thereof. Particularly, the present invention provides a compound of formula (I) useful for treating or preventing a disease, condition or disorder associated with protein kinases, preferably Janus Kinase family.Type: GrantFiled: November 22, 2013Date of Patent: March 17, 2015Assignee: Daiichi Sankyo Company, LimitedInventors: Ashwani Kumar Verma, Kumaragurubaran Nagaswamy, Lalima Sharma, Soma Ghosh, Balkrishna Ramchandra Kale, Aniruddha Mondal, Punit Kumar Srivastava, Sunanda Ghosh Dastidar, Rijwan Jaffer Momin, Pradip Balu Wagh, Sonali Nanasaheb Pansare, Pramod Raosaheb Markad, Yogesh Balasaheb Khairnar, Rie Miyauchi, Takeshi Murata, Masayuki Ishizaki, Masatoshi Nagamochi, Shin Iimura
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Publication number: 20140155398Abstract: The present invention provides a heterocyclic compound of formula (I), a pharmaceutically acceptable salt thereof, a prodrug thereof or a hydrate thereof, wherein A, A? B, D, R1, R2 and R3 are as defined herein, a pharmaceutical composition comprising a compound of formula (I) as an active ingredient, methods of production, and methods of use thereof. Particularly, the present invention provides a compound of formula (I) useful for treating or preventing a disease, condition or disorder associated with protein kinases, preferably Janus Kinase family.Type: ApplicationFiled: November 22, 2013Publication date: June 5, 2014Applicant: Daiichi Sankyo Company, LimitedInventors: Ashwani Kumar Verma, Kumaragurubaran Nagaswamy, Lalima Sharma, Soma Ghosh, Balkrishna Ramchandra Kale, Aniruddha Mondal, Punit Kumar Srivastava, Sunanda Ghosh Dastidar, Rijwan Jaffer Momin, Pradip Balu Wagh, Sonali Nanasaheb Pansare, Pramod Raosaheb Markad, Yogesh Balasaheb Khairnar, Rie Miyauchi, Takeshi Murata, Masayuki Ishizaki, Masatoshi Nagamochi, Shin Iimura
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Patent number: 7790689Abstract: The present invention relates to monosaccharide derivatives as anti-inflammatory agents. The compounds disclosed herein can be useful for inhibition and prevention of inflammation and associated pathologies including inflammatory and autoimmune diseases such as bronchial asthma, rheumatoid arthritis, type I diabetes, multiple sclerosis, allograft rejection, psoriasis, inflammatory bowel disease, ulcerative colitis, acne, atherosclerosis, cancer, pruritis and allergic rhinitis. Pharmacological compositions containing compounds disclosed herein and the methods of treating bronchial asthma, chronic obstructive pulmonary disease, rheumatoid arthritis, multiple sclerosis, type I diabetes, psoriasis, allograft rejection, inflammatory bowel disease, ulcerative colitis, acne, atherosclerosis, cancer, pruritis, allergic rhinitis and other inflammatory and/or autoimmune disorders, using the compounds are also provided.Type: GrantFiled: May 30, 2007Date of Patent: September 7, 2010Assignee: Ranbaxy Laboratories LimitedInventors: Ashwani Kumar Verma, Sanjay Malhotra, Sankaranarayanan Dharmarajan, Abhijit Ray, Rajkumar Shirumalla
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Patent number: 7674811Abstract: The present invention relates to 5-lipoxygenase inhibitors. Compounds disclosed herein can be useful in the treatment of bronchial asthma, chronic obstructive pulmonary disorder, arthritis, type I diabetes, multiple sclerosis, allograft rejection, psoriasis, inflammatory bowel disease, ulcerative colitis, acne, atherosclerosis, cancer, pruritis, urticaria, atopic dermatitis, allergic rhinitis, other inflammatory, and autoimmune diseases. Processes for the preparation of disclosed compounds, pharmaceutical compositions containing the disclosed compounds and their use as 5-lipoxygenase inhibitors are also provided.Type: GrantFiled: March 14, 2007Date of Patent: March 9, 2010Assignee: Ranbaxy Laboratories LimitedInventors: Ashwani Kumar Verma, Sanjay Malhotra, Abhijit Ray, Shirumalla Raj Kumar
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Publication number: 20090221600Abstract: Provided are novel pyrido-pyrimidine derivatives, having the structure of Formula (I): which can be used as anti-inflammatory agents. Also provided are pharmaceutical compositions comprising one or more pyrido-pyrimidine derivatives, as well as methods of treating autoimmune diseases, inflammation or associated pathologies, including for example, sepsis, rheumatoid arthritis, inflammatory bowel disease, type-1 diabetes, asthma, chronic obstructive pulmonary disorder, organ transplant rejection and psoriasis, comprising administering such compounds or pharmaceutical compositions comprising them.Type: ApplicationFiled: September 28, 2006Publication date: September 3, 2009Inventors: Ashwani Kumar Verma, Yogesh Bhaskarrao Waman, Venkata P. Palle, Atul Kondaskar, Abhijit Ray, Malini Bajpai, Geeta Sharma
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Publication number: 20080300196Abstract: The present invention relates to monosaccharide derivatives as anti-inflammatory agents. The compounds disclosed herein can be useful for inhibition and prevention of inflammation and associated pathologies including inflammatory, cancer, cardiovascular and autoimmune diseases such as bronchial asthma, rheumatoid arthritis, type-I diabetes, multiple sclerosis, allograft rejection, psoriasis, inflammatory bowel disease, ulcerative colitis, acne, atherosclerosis, pruritis or allergic rhinitis. Pharmacological compositions containing compounds disclosed herein and the methods of treating diseases such as bronchial asthma, rheumatoid arthritis, type-I diabetes, multiple sclerosis, cancer, cardiovascular diseases, allograft rejection, psoriasis, inflammatory bowel disease, ulcerative colitis, acne, atherosclerosis, pruritis or allergic rhinitis and other inflammatory and/or autoimmune disorders, using the compounds are also provided.Type: ApplicationFiled: October 3, 2007Publication date: December 4, 2008Inventors: Ashwani Kumar Verma, Sanjay Malhotra, Sankaranarayanan Dharmarajan, Rajkumar Shirumalla, Abhijit Ray
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Publication number: 20040249147Abstract: Methods for producing azole compounds useful as intermediates for antifungal compounds and compositions including reaction of epoxy alcohols with reactants having active hydrogen attached to nitrogen, oxygen or sulfur in the presence of redox coupling agents. In some embodiments, a procedure known as a Mitsunobu reaction is utilized for the transformations.Type: ApplicationFiled: July 2, 2004Publication date: December 9, 2004Inventors: Jitendra Sattigeri, Jasbir Singh Arora, Sanjay Malhotra, Ashwani Kumar Verma, Mohammad Salman
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Publication number: 20040242896Abstract: The present invention relates to the derivatives of specially substituted azole compounds which have improved anti-fungal activity as compared with presently available agents in this class and the processes for the preparation thereof. This invention also relates to pharmaceutical preparations containing the compounds of the present invention and their use in treating and/or preventing the fungal infections in mammals, preferably humans.Type: ApplicationFiled: June 28, 2004Publication date: December 2, 2004Inventors: Mohammad Salman, Rita Katoch, Ashwani Kumar Verma, Jitendra Sattigeri, Ashok Rattan
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Patent number: 6710049Abstract: The present invention relates to the derivatives of specially substituted azole compounds which have improved antifungal activity as compared with presently available agents in this class and the processes for the preparation thereof. This invention also relates to pharmaceutical preparations containing the compounds of the present invention and their use in treating and/or preventing the fungal infections in mammals, preferably humans.Type: GrantFiled: December 21, 2001Date of Patent: March 23, 2004Assignee: Ranbaxy Laboratories LimitedInventors: Mohammed Salman, Rita Katoch, Ashwani Kumar Verma, Jitendra Sattigeri, Ashok Rattan
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Patent number: 6670363Abstract: The present invention relates to the derivatives of specially substituted azole compounds which have improved antifungal activity as compared to known compounds such as fluconazole and itraconazole and the processes for the preparation thereof. This invention also relates to pharmaceutical compositions containing the compounds of the present invention and their use in treating and/or preventing fungal infections in mammals, preferably humans.Type: GrantFiled: May 22, 2000Date of Patent: December 30, 2003Assignee: Ranbaxy Laboratories LimitedInventors: Ashwani Kumar Verma, Sudershan K. Arora, Jasbir Singh Arora, Ashok Rattan
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Publication number: 20020119984Abstract: The present invention relates to the derivatives of specially substituted azole compounds which have improved antifungal activity as compared with presently available agents in this class and the processes for the preparation thereof. This invention also relates to pharmaceutical preparations containing the compounds of the present invention and their use in treating and/or preventing the fungal infections in mammals, preferably humans.Type: ApplicationFiled: December 21, 2001Publication date: August 29, 2002Inventors: Mohammed Salman, Rita Katoch, Ashwani Kumar Verma, Jitendra Sattigeri, Ashok Rattan