Patents by Inventor Ashwath Jayagopal

Ashwath Jayagopal has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20220184216
    Abstract: The present invention relates to conjugates comprising a small molecule targeting ligand and a cargo molecule.
    Type: Application
    Filed: March 3, 2020
    Publication date: June 16, 2022
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Ashwath JAYAGOPAL, Kameron V. KILCHRIST, Martin G. NUSSBAUMER
  • Publication number: 20210322422
    Abstract: The present invention provides the use of an Akt inhibitor for the treatment of ocular vascular disease, in particular age-related macular degeneration.
    Type: Application
    Filed: April 13, 2021
    Publication date: October 21, 2021
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Ashwath JAYAGOPAL, Debasish SINHA
  • Patent number: 10695446
    Abstract: A compound and method for detecting hypoxic cells and tissue are provided. The compound includes a probe selected from the group consisting of a hypoxia sensitive 2-nitroimidazole containing fluorescence imaging probe, a hypoxia sensitive reversible ON-OFF fluorescence imaging probe, a hypoxia sensitive azo-based fluorescence imaging probe, and combinations thereof. The method includes contacting the cells or tissue with the probe of any one of claims 1-13 and detecting fluorescent intensity of the cell or tissue, wherein increased fluorescent intensity indicates that the cells or tissue is hypoxic. Also provided are a method of synthesizing the compound and a method for synthesizing a therapeutic agent including the compound.
    Type: Grant
    Filed: May 2, 2016
    Date of Patent: June 30, 2020
    Assignee: Vanderbilt University
    Inventors: Imam Uddin, Ashwath Jayagopal, Jashim Uddin, John S. Penn, Lawrence J. Marnett
  • Publication number: 20180296639
    Abstract: The invention discloses peptides for the treatment and/or prophylaxis of diabetic retinopathy. The peptides of the invention comprise a glyceraldehyde-3-phosphate dehydrogenase (GAPDH) binding sequence and/or an E3 ubiquitin ligase seven in absentia homolog 1 (Siah1) binding sequence and an internalization sequence.
    Type: Application
    Filed: April 5, 2018
    Publication date: October 18, 2018
    Applicant: Hoffmann-La Roche Inc.
    Inventor: Ashwath JAYAGOPAL
  • Patent number: 10076578
    Abstract: Exemplary probes for detecting hypoxic cells and tissue have the structure of
    Type: Grant
    Filed: September 30, 2015
    Date of Patent: September 18, 2018
    Assignee: Vanderbilt University
    Inventors: Ashwath Jayagopal, Kwangho Kim, Gary Sulikowski, Stephanie Evans
  • Publication number: 20180085475
    Abstract: A compound and method for detecting hypoxic cells and tissue are provided. The compound includes a probe selected from the group consisting of a hypoxia sensitive 2-nitroimidazole containing fluorescence imaging probe, a hypoxia sensitive reversible ON-OFF fluorescence imaging probe, a hypoxia sensitive azo-based fluorescence imaging probe, and combinations thereof. The method includes contacting the cells or tissue with the probe of any one of claims 1-13 and detecting fluorescent intensity of the cell or tissue, wherein increased fluorescent intensity indicates that the cells or tissue is hypoxic. Also provided are a method of synthesizing the compound and a method for synthesizing a therapeutic agent including the compound.
    Type: Application
    Filed: May 2, 2016
    Publication date: March 29, 2018
    Inventors: Imam Uddin, Ashwath Jayagopal, Jashim Uddin, John S. Penn, Lawrence J. Marnett
  • Publication number: 20160232427
    Abstract: Methods and systems for detecting a gold nanorod (GNR) contrast agent in an optical coherence tomography (OCT) image of a sample are disclosed. In one example approach, a method comprises separating the OCT image at the location into short and long wavelength halves around a center wavelength of the OCT system, calculating a ratio between the short and long wavelength halves, and indicating a gold nanorod contrast agent at the location based on the ratio. In some examples, spectral fractionation may be employed to further divide the short and long wavelength halves into sub-bands to increase spectral contrast, reduce noise, and increase accuracy in detecting GNR in a sample.
    Type: Application
    Filed: November 3, 2015
    Publication date: August 11, 2016
    Applicants: VANDERBILT UNIVERSITY, OREGON HEALTH & SCIENCE UNIVERSITY
    Inventors: David HUANG, Yali JIA, Ashwath JAYAGOPAL, Gangjun LIU
  • Publication number: 20160151517
    Abstract: Exemplary probes for detecting hypoxic cells and tissue have the structure of
    Type: Application
    Filed: September 30, 2015
    Publication date: June 2, 2016
    Inventors: Ashwath Jayagopal, Kwangho Kim, Gary Sulikowski, Stephanie Evans
  • Publication number: 20060083781
    Abstract: In one aspect, the invention relates to functionalized solid lipid nanoparticles comprising a neutral lipid and a first functionalized polymer comprising at least one ionic or ionizable moiety and methods for providing same. In a further aspect, the invention relates to tumor targeting therapeutic systems, multimodal diagnostic therapeutic systems, thermoresponsive payload delivery systems, magnetic-driven targeting systems, therapeutic diagnostic systems, stabilized ink compositions, and cosmetic formulations comprising the solid lipid nanoparticles of the invention. In a further aspect, the invention relates to methods of delivering at least one biologically active agent, pharmaceutically active agent, magnetically active agent, or imaging agent across the blood-brain barrier, across a cellular lipid bilayer and into a cell, and to a subcellualr structure. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
    Type: Application
    Filed: October 14, 2005
    Publication date: April 20, 2006
    Inventors: V. Shastri, Eric Sussman, Ashwath Jayagopal