Patents by Inventor Ashwin Desai
Ashwin Desai has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230121577Abstract: Therapeutic methods and compositions for the in utero or postnatal treatment of diseases associated with alternative splicing are provided. Compositions of the disclosure include delivery nanoparticles with an inner region surrounded by a nucleic acid scaffolding that is, in turn, linked to therapeutic agents that promote healthy mRNA splicing phenotypes in fetal cells when the compositions are delivered to a fetus in utero or in a patient after birth.Type: ApplicationFiled: April 14, 2021Publication date: April 20, 2023Inventors: Tippi MacKenzie, Tejal Ashwin Desai, Stephan Sanders, Xiao Huang, Renan B. Sper
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Publication number: 20220364046Abstract: Thin film devices, e.g., multilayer thin film devices, that encapsulate cells for transplantation into a subject are provided. Also provided are methods of using and methods of preparing the subject devices. The thin film devices include a first porous polymer layer and a second porous polymer layer that define a lumen therebetween and encapsulate a population of cells within the lumen. The thin film devices can promote vascularization into the lumen of the device via the pores in the first polymer layer and/or second polymer layer; limit foreign body response to the device; limit ingress of cells, immunoglobulins, and cytokines into the lumen via the first and the second polymer layers; and release from the first polymer layer and/or the second polymer layer molecules secreted by the population of cells.Type: ApplicationFiled: December 21, 2021Publication date: November 17, 2022Inventors: Tejal Ashwin Desai, Crystal Nyitray, Ryan Chang
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Patent number: 11236301Abstract: Thin film devices, e.g., multilayer thin film devices, that encapsulate cells for transplantation into a subject are provided. Also provided are methods of using and methods of preparing the subject devices. The thin film devices include a first porous polymer layer and a second porous polymer layer that define a lumen therebetween and encapsulate a population of cells within the lumen. The thin film devices can promote vascularization into the lumen of the device via the pores in the first polymer layer and/or second polymer layer; limit foreign body response to the device; limit ingress of cells, immunoglobulins, and cytokines into the lumen via the first and the second polymer layers; and release from the first polymer layer and/or the second polymer layer molecules secreted by the population of cells.Type: GrantFiled: October 23, 2019Date of Patent: February 1, 2022Assignee: The Regents of the University of CaliforniaInventors: Tejal Ashwin Desai, Crystal Nyitray, Ryan Chang
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Publication number: 20210369714Abstract: The present disclosure provides methods for treating or preventing osteoarthritis in a subject in need thereof. In certain aspects, the methods include administering an inhibitor of insulin growth factor-1 (IGF-1) signaling to a joint of the subject in an amount effective to treat or prevent osteoarthritis. In certain aspects, the osteoarthritis treated or prevented by the methods disclosed herein may to be post-traumatic osteoarthritis.Type: ApplicationFiled: September 26, 2019Publication date: December 2, 2021Inventors: Daniel D. Bikle, Tejal Ashwin Desai, Long V. Le, Yongmei Wang
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Patent number: 11185499Abstract: Multilayer thin film devices that include a bioactive agent for elution to the surrounding tissue upon administration to a subject are provided. The multilayer thin film devices are useful as medical devices, such as ocular devices. Also provided are methods and kits for localized delivery of a bioactive agent to a tissue of a subject, and methods of preparing the subject devices. The multilayer thin film medical device includes a first layer, a bioactive agent and a second layer. The first and the second layers may be porous or non-porous. The devices have a furled structure, suitable for administration to a subject.Type: GrantFiled: April 17, 2020Date of Patent: November 30, 2021Assignee: The Regents of the University of CaliforniaInventors: Tejal Ashwin Desai, Mark Rory Steedman, Robert Bhisitkul, Daniel A. Bernards, Kevin D. Lance
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Patent number: 11173129Abstract: A microdevice containing a plurality of nanowires on a biocompatible surface, and methods of making and using the same are provided. Aspects of the present disclosure include forming a plurality of microdevices on a substrate where each microdevice includes a plurality of nanowires. The nanowires may be loaded with an active agent by disposing the active agent onto the surface of the nanowires. Also provided herein are kits that include the subject microdevices.Type: GrantFiled: February 6, 2020Date of Patent: November 16, 2021Assignee: The Regents of the University of CaliforniaInventors: Tejal Ashwin Desai, Hariharasudhan Chirra Dinakar, Cade B. Fox
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Publication number: 20200352871Abstract: A microdevice containing a plurality of nanowires on a biocompatible surface, and methods of making and using the same are provided. Aspects of the present disclosure include forming a plurality of microdevices on a substrate where each microdevice includes a plurality of nanowires. The nanowires may be loaded with an active agent by disposing the active agent onto the surface of the nanowires. Also provided herein are kits that include the subject microdevices.Type: ApplicationFiled: February 6, 2020Publication date: November 12, 2020Inventors: Tejal Ashwin Desai, Hariharasudhan Chirra Dinakar, Cade B. Fox
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Publication number: 20200315961Abstract: Multilayer thin film devices that include a bioactive agent for elution to the surrounding tissue upon administration to a subject are provided. The multilayer thin film devices are useful as medical devices, such as ocular devices. Also provided are methods and kits for localized delivery of a bioactive agent to a tissue of a subject, and methods of preparing the subject devices. The multilayer thin film medical device includes a first layer, a bioactive agent and a second layer. The first and the second layers may be porous or non-porous. The devices have a furled structure, suitable for administration to a subject.Type: ApplicationFiled: April 17, 2020Publication date: October 8, 2020Inventors: Tejal Ashwin Desai, Mark Rory Steedman, Robert Bhisitkul, Daniel A. Bernards, Kevin D. Lance
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Publication number: 20200056146Abstract: Thin film devices, e.g., multilayer thin film devices, that encapsulate cells for transplantation into a subject are provided. Also provided are methods of using and methods of preparing the subject devices. The thin film devices include a first porous polymer layer and a second porous polymer layer that define a lumen therebetween and encapsulate a population of cells within the lumen. The thin film devices can promote vascularization into the lumen of the device via the pores in the first polymer layer and/or second polymer layer; limit foreign body response to the device; limit ingress of cells, immunoglobulins, and cytokines into the lumen via the first and the second polymer layers; and release from the first polymer layer and/or the second polymer layer molecules secreted by the population of cells.Type: ApplicationFiled: October 23, 2019Publication date: February 20, 2020Inventors: Tejal Ashwin Desai, Crystal Nyitray, Ryan Chang
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Patent number: 10087413Abstract: Thin film devices, e.g., multilayer thin film devices, that encapsulate cells for transplantation into a subject are provided. Also provided are methods of using and methods of preparing the subject devices. The thin film devices include a first porous polymer layer and a second porous polymer layer that define a lumen therebetween and encapsulate a population of cells within the lumen. The thin film devices can promote vascularization into the lumen of the device via the pores in the first polymer layer and/or second polymer layer; limit foreign body response to the device; limit ingress of cells, immunoglobulins, and cytokines into the lumen via the first and the second polymer layers; and release from the first polymer layer and/or the second polymer layer molecules secreted by the population of cells.Type: GrantFiled: September 22, 2017Date of Patent: October 2, 2018Assignee: The Regents of the University of CaliforniaInventors: Tejal Ashwin Desai, Crystal Nyitray, Ryan Chang
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Publication number: 20180214571Abstract: Compositions and methods are provided for delivery of stem cells to a targeted tissue. A population of stem cells, including for example a regenerative stem cell population, is bound to magnetic vesicular particles. The magnetic vesicular particles comprise one or more magnetic nanoparticles within a lipid membrane, e.g. a liposomal structure. The cells are delivered to a targeted tissue by application of a magnetic field.Type: ApplicationFiled: January 31, 2018Publication date: August 2, 2018Inventors: Jayakumar Rajadas, Mohammadreza Mohammadi, Mohammed Inayathullah, Geoffrey C. Gurtner, Tejal Ashwin Desai
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Publication number: 20180010089Abstract: Thin film devices, e.g., multilayer thin film devices, that encapsulate cells for transplantation into a subject are provided. Also provided are methods of using and methods of preparing the subject devices. The thin film devices include a first porous polymer layer and a second porous polymer layer that define a lumen therebetween and encapsulate a population of cells within the lumen. The thin film devices can promote vascularization into the lumen of the device via the pores in the first polymer layer and/or second polymer layer; limit foreign body response to the device; limit ingress of cells, immunoglobulins, and cytokines into the lumen via the first and the second polymer layers; and release from the first polymer layer and/or the second polymer layer molecules secreted by the population of cells.Type: ApplicationFiled: September 22, 2017Publication date: January 11, 2018Inventors: Tejal Ashwin Desai, Crystal Nyitray, Ryan Chang
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Publication number: 20170197015Abstract: This disclosure relates to an article comprising at least one substrate and at least one porous coating formed on the at least one substrate. The substrate may be a medical device, for example a Nitinol stent. The porous coating may comprise a nanotubular coating. The nanotubular coating may comprise a compound of nickel, titanium and oxygen. This porous coating may improve re-endothelialization and/or reduce restenosis when it is used in the treatment of cardiovascular diseases.Type: ApplicationFiled: June 18, 2015Publication date: July 13, 2017Inventors: Tejal Ashwin DESAI, Phin Peng LEE
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Patent number: 8545604Abstract: A modular and compact adsorbent bed structure is disclosed for use in an adsorption-based gas separation plant. The conventional adsorbent bed in a gas separation plant is replaced with a plurality of modular adsorbent bed units connected to make the adsorbent bed structure. The modular design requires lower fabrication and maintenance costs; is easier to transport; and is easier to load with adsorbent material.Type: GrantFiled: December 19, 2012Date of Patent: October 1, 2013Assignee: Praxair Technology, Inc.Inventors: Ashwin Desai, Cem E. Celik, Mark William Ackley, James Smolarek
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Publication number: 20130118348Abstract: A modular and compact adsorbent bed structure is disclosed for use in an adsorption-based gas separation plant. The conventional adsorbent bed in a gas separation plant is replaced with a plurality of modular adsorbent bed units connected to make the adsorbent bed structure. The modular design requires lower fabrication and maintenance costs; is easier to transport; and is easier to load with adsorbent material.Type: ApplicationFiled: December 19, 2012Publication date: May 16, 2013Inventors: Ashwin Desai, Cem E. Celik, Mark William Ackley, James Smolarek
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Patent number: 8361205Abstract: A modular and compact adsorbent bed structure is disclosed for use in an adsorption-based gas separation plant. The conventional adsorbent bed in a gas separation plant is replaced with a plurality of modular adsorbent bed units connected to make the adsorbent bed structure. The modular design requires lower fabrication and maintenance costs; is easier to transport; and is easier to load with adsorbent material.Type: GrantFiled: December 23, 2009Date of Patent: January 29, 2013Assignee: Praxair Technology, Inc.Inventors: Ashwin Desai, Cem E. Celik, Mark William Ackley, James Smolarek
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Publication number: 20110146494Abstract: A modular and compact adsorbent bed structure is disclosed for use in an adsorption-based gas separation plant. The conventional adsorbent bed in a gas separation plant is replaced with a plurality of modular adsorbent bed units connected to make the adsorbent bed structure. The modular design requires lower fabrication and maintenance costs; is easier to transport; and is easier to load with adsorbent material.Type: ApplicationFiled: December 23, 2009Publication date: June 23, 2011Inventors: Ashwin Desai, Cem E. Celik, Mark William Ackley, James Smolarek
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Patent number: 7867320Abstract: The present invention relates to a dual feed and dual vacuum four bed VPSA process for selectively adsorbing a component from a feed stream, e.g., nitrogen from air, to produce an oxygen-enriched gas stream using a multi-port indexing drum valve, a system comprising a multi-port indexing drum valve and method for operating such a system.Type: GrantFiled: September 30, 2008Date of Patent: January 11, 2011Assignee: Praxair Technology, Inc.Inventors: Mohamed Safdar Allie Baksh, Michael S. Manning, Ashwin Desai, Preeti Chandra, Paul William Belanger
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Publication number: 20100077920Abstract: The present invention relates to a dual feed and dual vacuum four bed VPSA process for selectively adsorbing a component from a feed stream, e.g., nitrogen from air, to produce an oxygen-enriched gas stream using a multi-port indexing drum valve, a system comprising a multi-port indexing drum valve and method for operating such a system.Type: ApplicationFiled: September 30, 2008Publication date: April 1, 2010Inventors: MOHAMED SAFDAR ALLIE BAKSH, Michael S. Manning, Ashwin Desai, Preeti Chandra, Paul William Belanger