Abstract: The invention provides a method of treating preeclampsia, fetal growth restriction (FGR or IUGR), obesity in pregnancy, post-partum cardiomyopathy (heart failure in mothers), cancer and diabetic retinopathy, cardiomyopathy, myocardial infarction, wet microdegeneration and other disorders where angiogenesis is aberrant either diminished or exacerbated, comprising modulating the activity of micro RNA (miRNA). Also provided are an MiRNA modulator or a combination thereof or functional fragments or homologues thereof for use in the treatment of preeclampsia, fetal growth restriction, obesity in pregnancy, cancer, and diabetic retinopathy, cardiomyocyte infarction, wet microdegeneration as well as other disorder where angiogenesis is aberrant either diminished or exacerbated. Methods of modulating angiogenesis and pharmaceutical compositions using miR-122, miR-374b or inhibitors of miR-152 or miR195 are also provided together with methods of diagnosis using the miRNAs.

Abstract: Described is a method of diagnosis or prognosis of preeclampsia in a pregnant subject, comprising providing a sample from a pregnant subject and measuring the ratio between the amount of (a) one or both of sFlt-1 and PlGF, and (b) one or both of a breakdown product of heme and a breakdown product of arginine, in the sample. Also described are assay kits and a computer adapted for use in the method. Also described is a method of treating preeclampsia, comprising administering a pharmaceutically effective amount of L-arginine and/or citrulline and an inhibitor of arginase or pharmaceutically acceptable salts thereof. Also described is a method of treating cancer, comprising treating a subject with a therapeutically effective amount of an anti-VEGF compound, L-arginine and an arginase inhibitor.

Abstract: Provided are systems and methods tracking a prayer session of a device user and notifying the device user regarding prayer session activity. The method includes receiving motion information from an accelerometer of the device, receiving altitude information from an altimeter of the device, and receiving position information from a gyroscope of the device while the device user is engaged in the prayer session. The method further includes determining a prayer unit number or prayer position based on one or more of the received motion information, altitude information, and position information, and notifying the device user of the determined prayer unit number or prayer position.

Abstract: The application describes Hydrogen Sulphide (H2S), or a (H2S) generating compound or compound capable of stimulating H2S production in a pregnant subject, for use in the treatment of pre-eclampsia (PE) or fetal growth restriction.

Abstract: System and method for generating a display to create an artificial window, the method including displaying, on a display screen, a first signal received from a first source via a first input of the display screen, and emitting lighting on a bezel of the display screen or a display member around the bezel or on a border within the display screen while the first signal is displayed on the display screen.

Abstract: A system and method of multi-objective visualization utilize a multiple-objective optimizer approach to multi-objective optimization and specifically utilize a method for exploring and visualizing Pareto surfaces for any number of dimensions using an interactive graphical user interface. The general solution is to maintain all natural problem objectives separately and use a special multiple-objective optimizer to solve the problem. In this case there is no single solution point. Rather, the solution is a hyper dimensional surface in an objective space with various surface points representing different tradeoffs between objectives.