Abstract: The present invention relates to a method, including a diagnostic method, for characterising platelets. More particularly, the invention relates to methods for characterising platelets by immobilising platelets on a substrate for detection and subsequent characterisation, and to devices on which such a method may be practiced. The method comprises the steps of:—a. contacting a substrate that includes a plurality of discrete platelet-binding zones having a surface area of 7850 ?m2 orless with a fluid composition comprising platelets; and b. detecting platelets bound to the platelet-binding zones and thereby characterising platelets.

Abstract: The formation of a barrier layer within individual channels or cavities of a microfluidic device is described. The barrier layer is effected through a gas phase deposition process, desirably implemented in a plasma environment using a gas plasma reactor. Judicious selection of a precursor compound used within the gas plasma reactor can provide for generation of a layer on the individual surfaces. Desirably the surface or barrier layer is generated through the chemical adsorption of a metalloid oxide such as a silicon oxide layer on the surface of the individual channels or cavities.

Abstract: The present invention relates to a method, including a diagnostic method, for characterising platelets. More particularly, the invention relates to methods for characterising platelets by immobilising platelets on a substrate for detection and subsequent characterisation, and to devices on which such a method may be practiced. The method comprises the steps of:—a.contacting a substrate that includes a plurality of discrete platelet- binding zones having a surface area of 7850 ?m2 orless with a fluid composition comprising platelets; and b.detecting platelets bound to the platelet-binding zones and thereby characterising platelets.