Abstract: Respiratory isolation systems and devices for facilitating delivery of respiratory treatments to a patient. The device incudes a housing, a filtration unit, and at least one access port. The housing includes a front panel, a rear panel, one or more side panels, and a top panel that combine to define a chamber. The housing defines an open base that is open to the chamber, and the front panel defines an opening to the chamber. The filtration unit is mounted to the housing and includes a filter in fluid communication with the chamber. The access port is formed through one of the panels and permits user access to the chamber from an exterior of the housing. When connected to an airflow source as part of a respiratory isolation system, negative or positive pressure can continuously be provided to a patient within the chamber.