Patents by Inventor Assaf Friedler
Assaf Friedler has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11607814Abstract: An automatic method for autonomous interactions between robots, comprising an action of automatically receiving, by a transport robot, a request for transporting a service robot. The method comprises an action of automatically computing a location of the service robot. The method comprises an action of automatically moving the transport robot to the location of the service robot. The method comprises an action of automatically sending a signal from the service robot to the transport robot using a signal emitter incorporated into a mechanical element attached to the service robot. The method comprises an action of automatically coupling, using the signal, the mechanical element to a carrier element attached to the transport robot.Type: GrantFiled: February 25, 2021Date of Patent: March 21, 2023Assignee: BAR-ILAN UNIVERSITYInventors: Gal Kaminka, Assaf Friedler, Ari Yakir, Dan Erusalimchik, Yehuda Elmaliach
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Patent number: 11208443Abstract: The present invention provides peptides comprising a sequence derived from the human NAF-1 protein, analogs of said sequence or a retro-inverso sequence of said peptide or analog. The conjugates of such peptides are provided as well. The peptides and the conjugates of the present invention are useful in treating cancer, and in particular cancer in which the expression of NAF-1 is enhanced.Type: GrantFiled: February 12, 2018Date of Patent: December 28, 2021Assignee: YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD.Inventors: Rachel Nechushtai, Assaf Friedler, Anat Iosub-Amir, Merav Darash-Yahana, Yang-Sung Sohn, Dorit Michaeli
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Publication number: 20210178596Abstract: An automatic method for autonomous interactions between robots, comprising an action of automatically receiving, by a transport robot, a request for transporting a service robot. The method comprises an action of automatically computing a location of the service robot. The method comprises an action of automatically moving the transport robot to the location of the service robot. The method comprises an action of automatically sending a signal from the service robot to the transport robot using a signal emitter incorporated into a mechanical element attached to the service robot. The method comprises an action of automatically coupling, using the signal, the mechanical element to a carrier element attached to the transport robot.Type: ApplicationFiled: February 25, 2021Publication date: June 17, 2021Inventors: Gal KAMINKA, Assaf FRIEDLER, Ari YAKIR, Dan ERUSALIMCHIK, Yehuda ELMALIACH
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Patent number: 10960544Abstract: An automatic method for autonomous interactions between robots, comprising an action of automatically receiving, by a transport robot, a request for transporting a service robot. The method comprises an action of automatically computing a location of the service robot. The method comprises an action of automatically moving the transport robot to the location of the service robot. The method comprises an action of automatically sending a signal from the service robot to the transport robot using a signal emitter incorporated into a mechanical element attached to the service robot. The method comprises an action of automatically coupling, using the signal, the mechanical element to a carrier element attached to the transport robot.Type: GrantFiled: October 27, 2016Date of Patent: March 30, 2021Assignee: BAR-ILAN UNIVERSITYInventors: Gal Kaminka, Assaf Friedler, Ari Yakir, Dan Erusalimchik, Yehuda Elmaliach
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Publication number: 20200171159Abstract: The present invention provides compositions and methods for inducing DNA breaks in specifically-targeted cells, in particular cancer and HIV-infected cells, thereby promoting cell death.Type: ApplicationFiled: October 25, 2017Publication date: June 4, 2020Inventors: Abraham LOYTER, Assaf FRIEDLER
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Publication number: 20200010502Abstract: The present invention relates to a new approach for the synthesis of multiphosphorylated peptides. Specifically, the present invention provides a process, which enables the synthesis of multiphosphorylated peptides with up to seven phosphorylated Serine (pSer) and Threonine (pThr) residues, including such residues that are close in sequence.Type: ApplicationFiled: July 3, 2019Publication date: January 9, 2020Inventors: Assaf FRIEDLER, Samara simha reddy MAMDI, Mattan HUREVICH
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Publication number: 20190375805Abstract: The present invention provides peptides comprising a sequence derived from the human NAF-1 protein, analogs of said sequence or a retro-inverso sequence of said peptide or analog. The conjugates of such peptides are provided as well. The peptides and the conjugates of the present invention are useful in treating cancer, and in particular cancer in which the expression of NAF-1 is enhanced.Type: ApplicationFiled: February 12, 2018Publication date: December 12, 2019Inventors: Rachel NECHUSHTAI, Assaf FRIEDLER, Anat IOSUB-AMIR, Merav DARASH-YA-HANA, Yang-Sung SOHN, Dorit MICHAELI
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Publication number: 20180311822Abstract: An automatic method for autonomous interactions between robots, comprising an action of automatically receiving, by a transport robot, a request for transporting a service robot. The method comprises an action of automatically computing a location of the service robot. The method comprises an action of automatically moving the transport robot to the location of the service robot. The method comprises an action of automatically sending a signal from the service robot to the transport robot using a signal emitter incorporated into a mechanical element attached to the service robot. The method comprises an action of automatically coupling, using the signal, the mechanical element to a carrier element attached to the transport robot.Type: ApplicationFiled: October 27, 2016Publication date: November 1, 2018Inventors: Gal KAMINKA, Assaf FRIEDLER, Ari YAKIR, Dan ERUSALIMCHIK, Yehuda ELMALIACH
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Patent number: 9738878Abstract: Isolated peptides comprising sequences derived from the protein integrase of HIV-1, as well as their analogs, mixtures, conjugates with permeability enhancing moieties, and pharmaceutical compositions are disclosed. The peptides and compositions are capable of selectively killing HIV-1 infected cells and are used in treatment of HIV infection and AIDS.Type: GrantFiled: October 19, 2015Date of Patent: August 22, 2017Assignee: Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.Inventors: Aviad Levin, Zvi Hayouka, Assaf Friedler, Abraham Loyter
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Publication number: 20160340659Abstract: The present invention, in some embodiments thereof, relates to biologically active peptides and, more particularly, but not exclusively, to peptides from T2 RNase (RNASET2) having actin binding, pharmaceutical compositions comprising the same, therapeutic use thereof and methods for their production.Type: ApplicationFiled: January 29, 2015Publication date: November 24, 2016Inventors: Oded SHOSEYOV, Betty SCHWARTZ, Shani DORON, Liron NESIEL, Assaf FRIEDLER, Hadar AMARTELY, Levava ROIZ, Patricia SMIRNOFF, Iris LEWIN
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Publication number: 20160032263Abstract: Isolated peptides comprising sequences derived from the protein integrase of HIV-1, as well as their analogs, mixtures, conjugates with permeability enhancing moieties, and pharmaceutical compositions are disclosed. The peptides and compositions are capable of selectively killing HIV-1 infected cells and are used in treatment of HIV infection and AIDS.Type: ApplicationFiled: October 19, 2015Publication date: February 4, 2016Inventors: Aviad Levin, Zvi Hayouka, Assaf Friedler, Abraham Loyter
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Patent number: 9163067Abstract: Isolated peptides comprising sequences derived from the protein integrase of HIV-1, as well as their analogs, mixtures, conjugates with permeability enhancing moieties, and pharmaceutical compositions are disclosed. The peptides and compositions are capable of selectively killing HIV-1 infected cells and are used in treatment of HIV infection and AIDS.Type: GrantFiled: October 1, 2009Date of Patent: October 20, 2015Assignee: Yissum Research Development Company of The Hebrew University of Jerusalem LtdInventors: Aviad Levin, Zvi Hayouka, Assaf Friedler, Abraham Loyter
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Publication number: 20110257082Abstract: Isolated peptides comprising sequences derived from the protein integrase of HIV-1, as well as their analogs, mixtures, conjugates with permeability enhancing moieties, and pharmaceutical compositions are disclosed. The peptides and compositions are capable of selectively killing HIV-1 infected cells and are used in treatment of HIV infection and AIDS.Type: ApplicationFiled: October 1, 2009Publication date: October 20, 2011Inventors: Aviad Levin, Zvi Hayouka, Assaf Friedler, Abraham Loyter
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Patent number: 7747683Abstract: Method for allowing a user of a mobile terminal device having predetermined computational resources to remotely develop and operate upgraded content delivery applications. A client-side application and a corresponding remote application are installed on the terminal device and on a server connected to the terminal device. The remote application dynamically splits the tasks to be performed by the content delivery application between the client-side application and remote application, according to its computational resources and processes, in real-time, the content and its associated logic and input data to be delivered to the terminal device. The processed content is then transmitted to the terminal device over the data network and the content is rendered by the client-side application. The client-side application responds to inputs from the user and/or to messages from the server or further connected devices.Type: GrantFiled: December 28, 2006Date of Patent: June 29, 2010Assignee: Pike Ltd.Inventors: Shai Kurianski, Assaf Friedler
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Publication number: 20080307048Abstract: Method for allowing a user of a mobile terminal device having predetermined computational resources to remotely develop and operate upgraded content delivery applications. A client-side application and a corresponding remote application are installed on the terminal device and on a server connected to the terminal device. The remote application dynamically splits the tasks to be performed by the content delivery application between the client-side application and remote application, according to its computational resources and processes, in real-time, the content and its associated logic and input data to be delivered to the terminal device. The processed content is then transmitted to the terminal device over the data network and the content is rendered by the client-side application. The client-side application responds to inputs from the user and/or to messages from the server or further connected devices.Type: ApplicationFiled: December 28, 2006Publication date: December 11, 2008Applicant: PIKE LTD.Inventors: Assaf Friedler, Shai Kurianski
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Publication number: 20050008653Abstract: Disclosed is a method of stabilising the native state of a polypeptide, the method comprising exposing the polypeptide to a stabilising molecule capable of binding to the polypeptide at a site which at least partially overlaps a functional site in its native state.Type: ApplicationFiled: February 10, 2004Publication date: January 13, 2005Inventors: Assaf Friedler, Alan Fersht
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Patent number: 6664368Abstract: The design and the synthesis of backbone cyclic peptide analogs which functionally mimic the nuclear localization signal (NLS) region of macromolecules is disclosed. The principles of the invention are exemplified for the NLS sequences of the human immunodeficiency virus type 1 proteins MA, Vpr, Tat and NLS-like sequences of HIV-1 protein Vif. We disclose the discovery of a novel, highly potent backbone cyclic peptide, designated BCvir, which inhibits nuclear import with an IC50 value of 35 nM. This inhibitory potency is to be compared to 12 &mgr;M exhibited by the linear parent HIV-1 MA NLS peptide. BCvir also reduced HIV-1 production by 75% in infected non-dividing cultured human T-cells and was relatively resistant to tryptic digestion. These properties render backbone cyclic peptide analogs of NLS or NLS-like sequences as candidates for novel drugs based on blocking nuclear import of viral genomes.Type: GrantFiled: May 4, 2000Date of Patent: December 16, 2003Assignees: Yissum Research Development Co. of the Hebrew University of Jerusalem, Peptor Ltd.Inventors: Assaf Friedler, Abraham Loyter, Chaim Gilon, Amnon Wolf
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Publication number: 20030135377Abstract: A method for identifying digital music files that match a input signal bearing auditory information. An input signal is received and processed to extract basic musical information. The basic musical information is compared to musical information corresponding to digital music files, in order to identify digital music files that match the input signal.Type: ApplicationFiled: December 20, 2002Publication date: July 17, 2003Inventors: Shai Kurianski, Assaf Friedler