Patents by Inventor Assaf Friedler

Assaf Friedler has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11607814
    Abstract: An automatic method for autonomous interactions between robots, comprising an action of automatically receiving, by a transport robot, a request for transporting a service robot. The method comprises an action of automatically computing a location of the service robot. The method comprises an action of automatically moving the transport robot to the location of the service robot. The method comprises an action of automatically sending a signal from the service robot to the transport robot using a signal emitter incorporated into a mechanical element attached to the service robot. The method comprises an action of automatically coupling, using the signal, the mechanical element to a carrier element attached to the transport robot.
    Type: Grant
    Filed: February 25, 2021
    Date of Patent: March 21, 2023
    Assignee: BAR-ILAN UNIVERSITY
    Inventors: Gal Kaminka, Assaf Friedler, Ari Yakir, Dan Erusalimchik, Yehuda Elmaliach
  • Patent number: 11208443
    Abstract: The present invention provides peptides comprising a sequence derived from the human NAF-1 protein, analogs of said sequence or a retro-inverso sequence of said peptide or analog. The conjugates of such peptides are provided as well. The peptides and the conjugates of the present invention are useful in treating cancer, and in particular cancer in which the expression of NAF-1 is enhanced.
    Type: Grant
    Filed: February 12, 2018
    Date of Patent: December 28, 2021
    Assignee: YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD.
    Inventors: Rachel Nechushtai, Assaf Friedler, Anat Iosub-Amir, Merav Darash-Yahana, Yang-Sung Sohn, Dorit Michaeli
  • Publication number: 20210178596
    Abstract: An automatic method for autonomous interactions between robots, comprising an action of automatically receiving, by a transport robot, a request for transporting a service robot. The method comprises an action of automatically computing a location of the service robot. The method comprises an action of automatically moving the transport robot to the location of the service robot. The method comprises an action of automatically sending a signal from the service robot to the transport robot using a signal emitter incorporated into a mechanical element attached to the service robot. The method comprises an action of automatically coupling, using the signal, the mechanical element to a carrier element attached to the transport robot.
    Type: Application
    Filed: February 25, 2021
    Publication date: June 17, 2021
    Inventors: Gal KAMINKA, Assaf FRIEDLER, Ari YAKIR, Dan ERUSALIMCHIK, Yehuda ELMALIACH
  • Patent number: 10960544
    Abstract: An automatic method for autonomous interactions between robots, comprising an action of automatically receiving, by a transport robot, a request for transporting a service robot. The method comprises an action of automatically computing a location of the service robot. The method comprises an action of automatically moving the transport robot to the location of the service robot. The method comprises an action of automatically sending a signal from the service robot to the transport robot using a signal emitter incorporated into a mechanical element attached to the service robot. The method comprises an action of automatically coupling, using the signal, the mechanical element to a carrier element attached to the transport robot.
    Type: Grant
    Filed: October 27, 2016
    Date of Patent: March 30, 2021
    Assignee: BAR-ILAN UNIVERSITY
    Inventors: Gal Kaminka, Assaf Friedler, Ari Yakir, Dan Erusalimchik, Yehuda Elmaliach
  • Publication number: 20200171159
    Abstract: The present invention provides compositions and methods for inducing DNA breaks in specifically-targeted cells, in particular cancer and HIV-infected cells, thereby promoting cell death.
    Type: Application
    Filed: October 25, 2017
    Publication date: June 4, 2020
    Inventors: Abraham LOYTER, Assaf FRIEDLER
  • Publication number: 20200010502
    Abstract: The present invention relates to a new approach for the synthesis of multiphosphorylated peptides. Specifically, the present invention provides a process, which enables the synthesis of multiphosphorylated peptides with up to seven phosphorylated Serine (pSer) and Threonine (pThr) residues, including such residues that are close in sequence.
    Type: Application
    Filed: July 3, 2019
    Publication date: January 9, 2020
    Inventors: Assaf FRIEDLER, Samara simha reddy MAMDI, Mattan HUREVICH
  • Publication number: 20190375805
    Abstract: The present invention provides peptides comprising a sequence derived from the human NAF-1 protein, analogs of said sequence or a retro-inverso sequence of said peptide or analog. The conjugates of such peptides are provided as well. The peptides and the conjugates of the present invention are useful in treating cancer, and in particular cancer in which the expression of NAF-1 is enhanced.
    Type: Application
    Filed: February 12, 2018
    Publication date: December 12, 2019
    Inventors: Rachel NECHUSHTAI, Assaf FRIEDLER, Anat IOSUB-AMIR, Merav DARASH-YA-HANA, Yang-Sung SOHN, Dorit MICHAELI
  • Publication number: 20180311822
    Abstract: An automatic method for autonomous interactions between robots, comprising an action of automatically receiving, by a transport robot, a request for transporting a service robot. The method comprises an action of automatically computing a location of the service robot. The method comprises an action of automatically moving the transport robot to the location of the service robot. The method comprises an action of automatically sending a signal from the service robot to the transport robot using a signal emitter incorporated into a mechanical element attached to the service robot. The method comprises an action of automatically coupling, using the signal, the mechanical element to a carrier element attached to the transport robot.
    Type: Application
    Filed: October 27, 2016
    Publication date: November 1, 2018
    Inventors: Gal KAMINKA, Assaf FRIEDLER, Ari YAKIR, Dan ERUSALIMCHIK, Yehuda ELMALIACH
  • Patent number: 9738878
    Abstract: Isolated peptides comprising sequences derived from the protein integrase of HIV-1, as well as their analogs, mixtures, conjugates with permeability enhancing moieties, and pharmaceutical compositions are disclosed. The peptides and compositions are capable of selectively killing HIV-1 infected cells and are used in treatment of HIV infection and AIDS.
    Type: Grant
    Filed: October 19, 2015
    Date of Patent: August 22, 2017
    Assignee: Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.
    Inventors: Aviad Levin, Zvi Hayouka, Assaf Friedler, Abraham Loyter
  • Publication number: 20160340659
    Abstract: The present invention, in some embodiments thereof, relates to biologically active peptides and, more particularly, but not exclusively, to peptides from T2 RNase (RNASET2) having actin binding, pharmaceutical compositions comprising the same, therapeutic use thereof and methods for their production.
    Type: Application
    Filed: January 29, 2015
    Publication date: November 24, 2016
    Inventors: Oded SHOSEYOV, Betty SCHWARTZ, Shani DORON, Liron NESIEL, Assaf FRIEDLER, Hadar AMARTELY, Levava ROIZ, Patricia SMIRNOFF, Iris LEWIN
  • Publication number: 20160032263
    Abstract: Isolated peptides comprising sequences derived from the protein integrase of HIV-1, as well as their analogs, mixtures, conjugates with permeability enhancing moieties, and pharmaceutical compositions are disclosed. The peptides and compositions are capable of selectively killing HIV-1 infected cells and are used in treatment of HIV infection and AIDS.
    Type: Application
    Filed: October 19, 2015
    Publication date: February 4, 2016
    Inventors: Aviad Levin, Zvi Hayouka, Assaf Friedler, Abraham Loyter
  • Patent number: 9163067
    Abstract: Isolated peptides comprising sequences derived from the protein integrase of HIV-1, as well as their analogs, mixtures, conjugates with permeability enhancing moieties, and pharmaceutical compositions are disclosed. The peptides and compositions are capable of selectively killing HIV-1 infected cells and are used in treatment of HIV infection and AIDS.
    Type: Grant
    Filed: October 1, 2009
    Date of Patent: October 20, 2015
    Assignee: Yissum Research Development Company of The Hebrew University of Jerusalem Ltd
    Inventors: Aviad Levin, Zvi Hayouka, Assaf Friedler, Abraham Loyter
  • Publication number: 20110257082
    Abstract: Isolated peptides comprising sequences derived from the protein integrase of HIV-1, as well as their analogs, mixtures, conjugates with permeability enhancing moieties, and pharmaceutical compositions are disclosed. The peptides and compositions are capable of selectively killing HIV-1 infected cells and are used in treatment of HIV infection and AIDS.
    Type: Application
    Filed: October 1, 2009
    Publication date: October 20, 2011
    Inventors: Aviad Levin, Zvi Hayouka, Assaf Friedler, Abraham Loyter
  • Patent number: 7747683
    Abstract: Method for allowing a user of a mobile terminal device having predetermined computational resources to remotely develop and operate upgraded content delivery applications. A client-side application and a corresponding remote application are installed on the terminal device and on a server connected to the terminal device. The remote application dynamically splits the tasks to be performed by the content delivery application between the client-side application and remote application, according to its computational resources and processes, in real-time, the content and its associated logic and input data to be delivered to the terminal device. The processed content is then transmitted to the terminal device over the data network and the content is rendered by the client-side application. The client-side application responds to inputs from the user and/or to messages from the server or further connected devices.
    Type: Grant
    Filed: December 28, 2006
    Date of Patent: June 29, 2010
    Assignee: Pike Ltd.
    Inventors: Shai Kurianski, Assaf Friedler
  • Publication number: 20080307048
    Abstract: Method for allowing a user of a mobile terminal device having predetermined computational resources to remotely develop and operate upgraded content delivery applications. A client-side application and a corresponding remote application are installed on the terminal device and on a server connected to the terminal device. The remote application dynamically splits the tasks to be performed by the content delivery application between the client-side application and remote application, according to its computational resources and processes, in real-time, the content and its associated logic and input data to be delivered to the terminal device. The processed content is then transmitted to the terminal device over the data network and the content is rendered by the client-side application. The client-side application responds to inputs from the user and/or to messages from the server or further connected devices.
    Type: Application
    Filed: December 28, 2006
    Publication date: December 11, 2008
    Applicant: PIKE LTD.
    Inventors: Assaf Friedler, Shai Kurianski
  • Publication number: 20050008653
    Abstract: Disclosed is a method of stabilising the native state of a polypeptide, the method comprising exposing the polypeptide to a stabilising molecule capable of binding to the polypeptide at a site which at least partially overlaps a functional site in its native state.
    Type: Application
    Filed: February 10, 2004
    Publication date: January 13, 2005
    Inventors: Assaf Friedler, Alan Fersht
  • Patent number: 6664368
    Abstract: The design and the synthesis of backbone cyclic peptide analogs which functionally mimic the nuclear localization signal (NLS) region of macromolecules is disclosed. The principles of the invention are exemplified for the NLS sequences of the human immunodeficiency virus type 1 proteins MA, Vpr, Tat and NLS-like sequences of HIV-1 protein Vif. We disclose the discovery of a novel, highly potent backbone cyclic peptide, designated BCvir, which inhibits nuclear import with an IC50 value of 35 nM. This inhibitory potency is to be compared to 12 &mgr;M exhibited by the linear parent HIV-1 MA NLS peptide. BCvir also reduced HIV-1 production by 75% in infected non-dividing cultured human T-cells and was relatively resistant to tryptic digestion. These properties render backbone cyclic peptide analogs of NLS or NLS-like sequences as candidates for novel drugs based on blocking nuclear import of viral genomes.
    Type: Grant
    Filed: May 4, 2000
    Date of Patent: December 16, 2003
    Assignees: Yissum Research Development Co. of the Hebrew University of Jerusalem, Peptor Ltd.
    Inventors: Assaf Friedler, Abraham Loyter, Chaim Gilon, Amnon Wolf
  • Publication number: 20030135377
    Abstract: A method for identifying digital music files that match a input signal bearing auditory information. An input signal is received and processed to extract basic musical information. The basic musical information is compared to musical information corresponding to digital music files, in order to identify digital music files that match the input signal.
    Type: Application
    Filed: December 20, 2002
    Publication date: July 17, 2003
    Inventors: Shai Kurianski, Assaf Friedler