Abstract: A prosthetic device, such as a prosthetic heart valve, can include a frame comprising a plurality of axially extending posts and a plurality of struts that connect the plurality of axially extending posts. One or more of these posts can be configured as expansion and locking mechanisms. For example, the posts that are configured as expansion and locking mechanisms can include proximal and distal members that are axially movable relative to one another, and are moveable via rotation of a threaded rod connected therebetween. An actuation assembly can include three-subassemblies configured for actuation of the threaded rod, and can be configured to limit unwanted axial and rotational movement of the prosthetic heart valve during radial expansion and/or compression of the frame.

Abstract: A method includes, receiving, on a surface of an anatomical map of a patient organ having a first presentation, a selection of a first selected region, which is intended to have a second presentation, different from the first presentation. A perimeter of the first selected region, and at least an unselected area positioned within the first selected region, are identified. A second selected region is produced, the second selected region includes the first selected region and the unselected area. The anatomical map, having the second presentation applied to the second selected region, is displayed.

Abstract: A method includes, receiving, on a surface of an anatomical map of a patient organ having a first presentation, a selection of a first selected region, which is intended to have a second presentation, different from the first presentation. A perimeter of the first selected region, and at least an unselected area positioned within the first selected region, are identified. A second selected region is produced, the second selected region includes the first selected region and the unselected area. The anatomical map, having the second presentation applied to the second selected region, is displayed.

Abstract: In one embodiment, a system for disease-detection includes a machine learning-based (ML-based) disease-detection model trained on a dataset of detection events, wherein one or more ML-models is operable to receive sensor data associated with one or more detection animals that have been exposed to a biological sample of a patient, process the sensor data to generate one or more feature representations, and calculate, based on the one or more feature representations, one or more confidence scores corresponding to one or more disease states associated with the biological sample, wherein each confidence score indicates a likelihood of the respective disease state being present in the patient.

Abstract: A catheter device includes a tube, and an extracorporeal unit coupled to a proximal end of the tube. An implant includes a series of anchors and a tether. The series of anchors includes a first anchor and other anchors, arranged along the extracorporeal unit. Each of the anchors includes a tissue-engaging element, and a head that defines an eyelet. The tether extends, along the extracorporeal unit, through the eyelet of each of the other anchors to the first anchor such that (i) the first anchor is advanceable, with a distal end of the tether, distally into and through the tube toward the tissue, and (ii) subsequently, the other anchors are slidable, sequentially, over and along the tether, distally into and through the tube toward the first anchor. Other applications are also described.

Abstract: An implant comprises a wall that surrounds a lumen. A delivery tool comprises a catheter, a control assembly, and an ultrasound tool. The catheter is transluminally advanceable into a subject, and has a distal opening. The implant can be delivered via the catheter. The control assembly can advance at least a portion of the wall out of the distal opening, and can steer the catheter to place the portion against a site of a tissue of the subject, the site disposed distally from the portion and opposite the distal opening. The ultrasound tool can (i) position an ultrasound transceiver within the lumen and facing the portion, and (ii) facilitate imaging of the site by transmitting ultrasound energy through the portion. An anchor driver can anchor the implant to the tissue by driving an anchor through the portion and into the site. Other embodiments are also described.

Abstract: A radiopaque frame is transluminally advanced to an atrium of a heart of a subject. The frame is expanded within a valve adjacent the atrium such that part of the frame remains disposed in the atrium. While the frame remains expanded within the valve, progressive portions of an annuloplasty structure are progressively positioned and anchored around the annulus using multiple anchors by, for each of the anchors sequentially (i) while fluoroscopically imaging the frame and a distal end of a delivery tool, and facilitated by mechanical guidance from the frame, positioning the distal end of the delivery tool between the frame and a wall of the atrium; and (ii) driving the anchor into the annulus laterally from the frame. Subsequently, the frame is contracted and withdrawn from the subject while leaving the annuloplasty structure anchored around the annulus. Other embodiments are also described.

Abstract: Using a delivery tool, an annuloplasty structure is secured on an annulus of a valve of a subject, the annuloplasty structure including (i) a flexible sleeve that defines a longitudinal lumen therethrough, and (ii) an elongate contraction member attached to the flexible sleeve. Subsequently, while the delivery tool is coupled to the annuloplasty structure, the sleeve is longitudinally contracted by drawing the contraction member into the lumen. Other embodiments are also described.

Abstract: The present invention relates to packaging and in particular, to sterile packaging that is configured to be self-stackable and interlocking. A sterile packaging comprising a packaging compartment provided having one open face through which the compartment may be filled, the open face forms a sterile sealing face that is to be sealed with and receive a sterile barrier. The package features at least one coupling interface along an external surface having male to female couplers configured to facilitate piggy-back coupling between two packaging.

Abstract: The present invention relates to packaging and in particular, to sterile packaging that is configured to be self-stackable and interlocking. A sterile packaging comprising a packaging compartment provided having one open face through which the compartment may be filled, the open face forms a sterile sealing face that is to be sealed with and receive a sterile barrier. The package features at least one coupling interface along an external surface having male to female couplers configured to facilitate piggy-back coupling between two packaging.

Abstract: A cryosurgical instrument that includes: an external shaft with a cryotip; a heat exchanger that cools a portion of the external shaft and the tip when cryogen is received thereby; and a flow diverter that receives a flow of cryogen, that splits the received flow of cryogen into two or more split cryogen flows, and that delivers the split cryogen flows to the heat exchanger, the flow diverter including a first passage with one or more inlet ports at an upstream side of the diverter that receive the flow of cryogen and two or more outlet ports at a downstream side of the diverter and in fluid communication with the heat exchanger.

Abstract: A cryosurgical instrument that includes: an external shaft with a cryotip; a heat exchanger that cools a portion of the external shaft and the tip when cryogen is received thereby; and a flow diverter that receives a flow of cryogen, that splits the received flow of cryogen into two or more split cryogen flows, and that delivers the split cryogen flows to the heat exchanger, the flow diverter including a first passage with one or more inlet ports at an upstream side of the diverter that receive the flow of cryogen and two or more outlet ports at a downstream side of the diverter and in fluid communication with the heat exchanger.