Patents by Inventor Assaf WEINER

Assaf WEINER has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHODS OF PROGNOSING, DETERMINING TREATMENT COURSE AND TREATING MULTIPLE MYELOMA
    Publication number: 20230272484
    Abstract: A method of prognosing a subject diagnosed with multiple myeloma (MM) is provided. Also provided a method of treating a subject diagnosed with MM selected expressing intracellular PPIA and/or RRM2 above a predetermined threshold, the method comprising administering to the subject a therapeutically effective amount of at least one agent which specifically down-regulates activity or expression of PPIA and/or RRM2, thereby treating the subject.
    Type: Application
    Filed: May 3, 2023
    Publication date: August 31, 2023
    Applicants: Yeda Research and Development Co. Ltd., Ichilov Tech Ltd.
    Inventors: Ido AMIT, Assaf WEINER, Mor ZADA, Chamutal BORNSTEIN-OVITS, Shuang-Yin WANG, Yael COHEN
  • METHODS OF TREATING CANCER
    Publication number: 20220372145
    Abstract: A method of reducing the immune suppressor activity of myeloid cells is disclosed. The method comprises contacting myeloid cells with an effective amount of an agent which specifically reduces the amount and/or activity of myeloid cells expressing both Triggering Receptor Expressed On Myeloid Cells 2 (Trem2) and Transmembrane glycoprotein NMB (Gpnmb). The method can be used for treating cancer. Antibodies and bi-specific antibodies are also disclosed.
    Type: Application
    Filed: July 29, 2022
    Publication date: November 24, 2022
    Applicant: Yeda Research and Development Co. Ltd.
    Inventors: Ido AMIT, Assaf WEINER, Yonatan KATZENELENBOGEN, Adam YALIN, Fadi SHEBAN
  • CRISP-seq, an integrated method for massively parallel single cell RNA-seq and CRISPR pooled screens
    Patent number: 11485971
    Abstract: An expression construct is disclosed which comprises: (i) a DNA sequence which encodes at least one guide RNA (gRNA) operatively linked to a transcriptional regulatory sequence so as to allow expression of the gRNA in a target cell; (ii) a barcode sequence for identification of the at least one gRNA operatively linked to a transcriptional regulatory sequence so as to allow expression of the barcode sequence in the target cell.
    Type: Grant
    Filed: September 14, 2017
    Date of Patent: November 1, 2022
    Assignee: Yeda Research and Development Co. Ltd.
    Inventors: Ido Amit, Diego Jaitin, David Lara-Astiaso, Assaf Weiner, Ido Yofe
  • METHOD FOR STABILIZING INTRACELLULAR RNA
    Publication number: 20220307008
    Abstract: A method of permeabilizing a cell is disclosed. Kits for permeabilizing cells and analysing RNA contents are also disclosed.
    Type: Application
    Filed: June 16, 2020
    Publication date: September 29, 2022
    Applicant: Yeda Research and Development Co. Ltd.
    Inventors: Ido AMIT, Ido YOFE, Diego JAITIN, Yonatan KATZENELENBOGEN, Mami LENNIKOV, Assaf WEINER, Hadas KEREN-SHAUL
  • METHODS OF TREATING NEURODEGENERATIVE DISEASES BY INDUCING DISEASE-ASSOCIATED MICROGLIA (DAM) CELLS
    Publication number: 20190367623
    Abstract: An active agent that causes an increase in the number of disease-associated microglia (DAM) for use in treating a neurodegenerative disease is provided.
    Type: Application
    Filed: January 17, 2018
    Publication date: December 5, 2019
    Inventors: Michal SCHWARTZ-EISENBACH, Ido AMIT, Hadas KEREN-SHAUL, Amit SPINRAD, Assaf WEINER, Orit MATCOVITCH NATHAN, Raz DVIR
  • CRISP-SEQ, AN INTEGRATED METHOD FOR MASSIVELY PARALLEL SINGLE CELL RNA-SEQ AND CRISPR POOLED SCREENS
    Publication number: 20190194653
    Abstract: An expression construct is disclosed which comprises: (i) a DNA sequence which encodes at least one guide RNA (gRNA) operatively linked to a transcriptional regulatory sequence so as to allow expression of the gRNA in a target cell; (ii) a barcode sequence for identification of the at least one gRNA operatively linked to a transcriptional regulatory sequence so as to allow expression of the barcode sequence in the target cell.
    Type: Application
    Filed: September 14, 2017
    Publication date: June 27, 2019
    Applicant: Yeda Research and Development Co. Ltd.
    Inventors: Ido AMIT, Diego JAITIN, David LARA-ASTIASO, Assaf WEINER, Ido YOFE