Patents by Inventor Astrid P. Koudelka

Astrid P. Koudelka has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method and kit for detecting polyriboadenosine segments and messenger RNA
    Patent number: 4735897
    Abstract: RNA such as messenger RNA is digested to nucleotide phosphates including AMP or ADP. The ATP or a byproduct of the phosphorylation, e.g., pyruvate, is detected. Exemplary enzymes used (with appropriate co-reactants and co-factors) are: (1) polynucleotide phosphorylase, pyruvate kinase and luciferase, or (2) phosphodiesterase (or RNase), myokinase, pyruvate kinase and luciferase. The phosphorylation to ATP (e.g., with pyruvate kinase) is preferably coupled with the previous (reversible) enzymatic step.
    Type: Grant
    Filed: May 2, 1985
    Date of Patent: April 5, 1988
    Assignees: Allied Corporation, Genetics Institute, Inc.
    Inventors: Calvin P. H. Vary, Steven E. Diamond, Neil M. Wolfman, Astrid P. Koudelka