Patents by Inventor ASTRID SCHAEFER

ASTRID SCHAEFER has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20230068713
    Abstract: The present invention relates to host cells and their use wherein the host cells are capable of producing D-ribulose and incapable of or have a reduced capability of converting D-ribulose to a molecule other than ribitol, wherein the host cells comprise a heterologous nucleic acid sequence encoding a polypeptide capable of converting D-ribulose to ribitol with a cofactor preference for NADPH.
    Type: Application
    Filed: December 17, 2020
    Publication date: March 2, 2023
    Inventors: Astrid SCHÄFER, Yiming CHANG, Sumire Honda MALCA
  • Patent number: 10829742
    Abstract: The present invention relates to a recombinant microbial host for the production of xylitol, the recombinant microbial host containing a nucleic acid sequence encoding a NAD+-specific D-arabitol 4-oxidoreductase (EC 1.1.1.11) using D-arabitol as substrate and producing D-xylulose as product, and a nucleic acid sequence encoding a NADPH-specific xylitol dehydrogenase using D-xylulose as substrate and producing xylitol as product.
    Type: Grant
    Filed: September 13, 2019
    Date of Patent: November 10, 2020
    Assignee: ROQUETTE FRERES
    Inventors: Astrid Schaefer, Melanie Diefenbacher, Yiming Chang, Sumire Honda Malca, Markus Schwab, Sophie Defretin, Tania Gerard, Arnaud Heysen, Friederike Thor
  • Publication number: 20200032224
    Abstract: The present invention relates to a recombinant microbial host for the production of xylitol, the recombinant microbial host containing a nucleic acid sequence encoding a NAD+-specific D-arabitol 4-oxidoreductase (EC 1.1.1.11) using D-arabitol as substrate and producing D-xylulose as product, and a nucleic acid sequence encoding a NADPH-specific xylitol dehydrogenase using D-xylulose as substrate and producing xylitol as product.
    Type: Application
    Filed: September 13, 2019
    Publication date: January 30, 2020
    Applicant: ROQUETTE FRERES
    Inventors: Astrid SCHAEFER, Melanie DIEFENBACHER, Yiming CHANG, Sumire HONDA MALCA, Markus SCHWAB, Sophie DEFRETIN, Tania GERARD, Arnaud HEYSEN, Friederike THOR
  • Patent number: 10494614
    Abstract: The present invention relates to a recombinant microbial host for the production of xylitol, the recombinant microbial host containing a nucleic acid sequence encoding an NAD+-specific D-arabitol 4-oxidoreductase (EC 1.1.1.11) using D-arabitol as substrate and producing D-xylulose as product, and a nucleic acid sequence encoding an NADPH-specific xylitol dehydrogenase using D-xylulose as substrate and producing xylitol as product.
    Type: Grant
    Filed: June 17, 2015
    Date of Patent: December 3, 2019
    Assignee: ROQUETTE FRERES
    Inventors: Astrid Schaefer, Melanie Diefenbacher, Yiming Chang, Sumire Honda Malca, Markus Schwab, Sophie Defretin, Tania Gerard, Arnaud Heysen, Friederike Thor
  • Publication number: 20170130209
    Abstract: The present invention relates to a recombinant microbial host for the production of xylitol, the recombinant microbial host containing a nucleic acid sequence encoding an NAD+-specific D-arabitol 4-oxidoreductase (EC 1.1.1.11) using D-arabitol as substrate and producing D-xylulose as product, and a nucleic acid sequence encoding an NADPH-specific xylitol dehydrogenase using D-xylulose as substrate and producing xylitol as product.
    Type: Application
    Filed: June 17, 2015
    Publication date: May 11, 2017
    Inventors: ASTRID SCHAEFER, MELANIE DIEFENBACHER, YIMING CHANG, SUMIRE HONDA MALCA, MARKUS SCHWAB, SOPHIE DEFRETIN, TANIA GERARD, ARNAUD HEYSEN, FRIEDERIKE THOR