Abstract: Embodiments pertain to an access port assembly configured to assist in creating access for and accommodating a medical device extending from outside a patient body and terminating in a cavity internal to the patient body. The assembly may comprise a guide element comprising a guide channel having a longitudinal guide axis extending from an inlet to an outlet of the guide element for guiding the medical device through the guide channel. The guide element may be movably coupled with the fixation base by an articulating linkage to allow selecting an orientation of the guide channel relative to the site of interest of the patient body. The articulating linkage may be implemented as a ball-and-socket linkage. Embodiments also pertain to a system for controlling delivery of fluid into the patient body and/or removal of fluid from the patient body, via one or more access ports.