Abstract: The present investigation involves designing of a novel hexapeptide, which spontaneously self-assembles to form nanovesicles in physiological conditions. This peptide not only strongly binds with ?-tubulin near taxol binding site, but also binds with microtubule lattice in-vitro, as well as intracellular microtubule networks. Interestingly, it inhibits amyloid fibril formation upon co-incubation with A? peptide in-vitro and shows excellent neuroprotection against A? infected neuronal cell (PC12). Present invention provides a novel approach to produce a peptide-based therapeutics for neurodegenerative disease.

Abstract: The present investigation involves designing of a novel hexapeptide, which spontaneously self-assembles to form nanovesicles in physiological conditions. This peptide not only strongly binds with ?-tubulin near taxol binding site, but also binds with microtubule lattice in-vitro, as well as intracellular microtubule networks. Interestingly, it inhibits amyloid fibril formation upon co-incubation with A? peptide in-vitro and shows excellent neuroprotection against A? infected neuronal cell (PC12). Present invention provides a novel approach to produce a peptide-based therapeutics for neurodegenerative disease.

Abstract: Chemically-modified fatty acids are prepared by reacting epoxidized fatty acids, their esters or triglyceride oils with amines of cyclic or aromatic hydrocarbons. The fatty acid derivatives produced are of the formula: wherein R is an H, branched or straight chain alkyl or alkenyl group, aromatic-containing group, glycerol, or glyceride, R? is a C3 to C29 aliphatic chain comprising one or more of the derivatized methylene groups of the formula: wherein R1 and R2 are independently selected from the group consisting of H, cyclic hydrocarbons, substituted cyclic hydrocarbons, and aryl groups, with the proviso that only one of said R1 and R2 may be H. These fatty acid derivatives have utility as antiwear/antifriction additives for industrial oils and automotive applications.

Abstract: A hydrocarbon resin is prepared by (1) thermally polymerizing a mixture consisting essentially of (a) about 5% to 25% by weight styrene or aliphatic or aromatic substituted styrene, and (b) about 95% to 75% by weight based on total monomer content of a cyclic diolefin component comprising at least about 50% by weight dicyclopentadiene. A method of producing an aromatic-modified resin having a Mz of less than 2000 through the addition of about 5% to 25% by weight styrene in combination with about 95% to about 75% DCPD monomer at a rate to consume styrene monomer at a the rate at which it is added. Hydrogenation of this resin produces light colored, thermally stable products that are useful as tackifiers in adhesives.

Abstract: A hydrocarbon resin is prepared by (1) thermally polymerizing a mixture consisting essentially of (a) about 5% to 25% by weight styrene or aliphatic or aromatic substituted styrene, and (b) about 95% to 75% by weight based on total monomer content of a cyclic diolefin component comprising at least about 50% by weight dicyclopentadiene.

Abstract: Curable polymer compositions comprising a crosslinkable polymeric component; an initiator component; and an allyl compound component.

Abstract: A composition comprising:(a) polyethylene;(b) as a scorch inhibitor, 1,1-diphenylethylene, substituted or unsubstituted;(c) optionally, a cure booster; and(d) an organic peroxide.

Abstract: The alkylation resins of this invention comprise the alkylation reaction product of (a) at least one substituted or unsubstituted polycyclic aromatic compound and (b) at least one ethylenically unsaturated hydrocarbon monomer having at least two carbon-carbon double bonds that reacts with the polycyclic aromatic compound by alkylation in the presence of an acid catalyst, wherein the ratio of (a) to (b) in the resin is about 1:9 to about 3:1 by weight. The resins have a weight average molecular weight of less than 10,000 measured by size exclusion chromatography, and a Ring & Ball softening point of about 50.degree. to about 250.degree. C. Because of their high softening point and low molecular weight, the resins are useful in a variety of applications such as flow rate modifiers for engineering polymers, tackifiers for adhesives, and flushing agents for inks.

Abstract: Novel compounds are provided which exhibit high levels of anti-parasitic activity, specifically against parasites of the genus Trypanosoma. The compounds are comprised of aryl-substituted quaternary heteroaromatic salts which include a positively charged imidazolium or other heterocyclic ring, a linking group, a phenyl ring, and a polar functional group. The polar functional group is preferably a quanylhydrazone or a heterocyclic hydrazone. A method is also provided for treating the diseases associated with Trypanosoma parasites which comprises administering to infected animals or humans an effective amount of a compound of the present invention.