Patents by Inventor Athanas Koynov

Athanas Koynov has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for preparing pharmaceutical compositions
    Patent number: 11975100
    Abstract: A process for preparing and isolating pharmaceutical active ingredient particles having a particle size of between about 0.1 and 30 microns, wherein a slurry comprising the active ingredient and one or more pharmaceutically acceptable excipients is fed into a thin film evaporator under suitable conditions for less than 10 minutes sufficient to generate solid matrix particles comprising active ingredient and one or more excipients, wherein the particles have less than 5% residual solvent.
    Type: Grant
    Filed: September 29, 2021
    Date of Patent: May 7, 2024
    Assignee: Merck Sharp & Dohme LLC
    Inventors: Luke R. Schenck, David J. Lamberto, Joseph L. Kukura, II, Francisco J. Guzman, Aaron Cote, Athanas Koynov
  • Process for preparing large size isoxazoline particles
    Patent number: 11858904
    Abstract: The application relates to a process to produce large isoxazoline compound particles which comprises initiating crystallization and then maintaining the temperature of the crystallization in the metastable region by removing, reheating and recycling a portion of the solvent thereby allowing the existing crystals to grow larger while minimizing the formation of newer smaller crystals.
    Type: Grant
    Filed: November 6, 2018
    Date of Patent: January 2, 2024
    Assignee: Intervet Inc.
    Inventors: Luke Ryan Schenck, Athanas Koynov, George X. Zhou, Aaron Cote
  • DRUG DELIVERY SYSTEM FOR THE DELIVERY OF ANTIVIRAL AGENTS AND CONTRACEPTIVES
    Publication number: 20230149296
    Abstract: This invention relates to novel implant drug delivery systems for long-acting delivery of antiviral and contraceptive drugs. These compositions are useful for the treatment or prevention of human immunodeficiency virus (HIV) infection and the prevention of pregnancy.
    Type: Application
    Filed: April 30, 2021
    Publication date: May 18, 2023
    Applicant: Merck Sharp & Dohme LLC
    Inventors: Morgan B. Giles, Seth P. Forster, Stephanie Elizabeth Barrett, Athanas Koynov, Ryan S. Teller
  • DRUG DELIVERY SYSTEM FOR THE DELIVERY OF ANTIVIRAL AGENTS
    Publication number: 20220362277
    Abstract: This invention relates to novel implant drug delivery systems for long-acting delivery of antiviral drugs. These compositions are useful for the treatment or prevention of human immunodeficiency virus (HIV) infection.
    Type: Application
    Filed: August 11, 2020
    Publication date: November 17, 2022
    Applicant: Merck Sharp & Dohme Corp.
    Inventors: Seth P. Forster, Stephanie Elizabeth Barrett, Ryan S. Teller, Morgan B. Giles, Athanas Koynov
  • PROCESS FOR PREPARING PHARMACEUTICAL COMPOSITIONS
    Publication number: 20220016031
    Abstract: A process for preparing and isolating pharmaceutical active ingredient particles having a particle size of between about 0.1 and 30 microns, wherein a slurry comprising the active ingredient and one or more pharmaceutically acceptable excipients is fed into a thin film evaporator under suitable conditions for less than 10 minutes sufficient to generate solid matrix particles comprising active ingredient and one or more excipients, wherein the particles have less than 5% residual solvent.
    Type: Application
    Filed: September 29, 2021
    Publication date: January 20, 2022
    Applicant: Merck Sharp & Dohme Corp.
    Inventors: Luke R. Schenck, David J. Lamberto, Joseph L. Kukura, II, Francisco J. Guzman, Aaron Cote, Athanas Koynov
  • Process for Preparing Large Size Isoxazoline Particles
    Publication number: 20200331867
    Abstract: The application relates to a process to produce large isoxazoline compound particles which comprises initiating crystallization and then maintaining the temperature of the crystallization in the metastable region by removing, reheating and recycling a portion of the solvent thereby allowing the existing crystals to grow larger while minimizing the formation of newer smaller crystals.
    Type: Application
    Filed: November 6, 2018
    Publication date: October 22, 2020
    Applicant: Intervet Inc.
    Inventors: Luke Ryan Schenck, Athanas Koynov, George X. Zhou, Aaron Cote
  • PROCESS FOR PREPARING PHARMACEUTICAL COMPOSITIONS
    Publication number: 20200261365
    Abstract: A process for preparing and isolating pharmaceutical active ingredient particles having a particle size of between about 0.1 and 30 microns, wherein a slurry comprising the active ingredient and one or more pharmaceutically acceptable excipients is fed into a thin film evaporator under suitable conditions for less than 10 minutes sufficient to generate solid matrix particles comprising active ingredient and one or more excipients, wherein the particles have less than 5% residual solvent.
    Type: Application
    Filed: December 13, 2016
    Publication date: August 20, 2020
    Applicant: Merck Sharp & Dohme Corp.
    Inventors: Luke R. Schenck, David J. Lamberto, Joseph L. Kukura, II, Francisco J. Guzman, Aaron Cote, Athanas Koynov