Abstract: It is an object of the present invention to enable simple design and change of a probe set that can be easily reused corresponding to a DNA microarray. A nucleic acid information processing device comprises: a storage unit that stores information on a plurality of base sequences; a threshold value receiving unit adapted to receive information that identifies a similarity threshold; a cluster configuration unit adapted to configure clusters by classifying the plurality of base sequences based on the similarity threshold; and a representative base sequence setting unit adapted to set one of the base sequences included in the cluster as a representative base sequence.

Abstract: A nucleic acid information processing device includes a storage unit that stores first base sequence information including information on a plurality of base sequences, and second base sequence information including information on a plurality of base sequences; a threshold value receiving unit adapted to receive information that identifies a similarity threshold; a hybridization unit adapted to identify a degree of similarity and a starting position and a finishing position of a similar portion for one to one combinations with the base sequences included in the first base sequence information as a target, and the base sequences included in the second base sequence information as a probe; and a similar base sequence counting unit adapted to count for each probe a number of the targets for which the identified degree of similarity is greater than or equal to the similarity threshold, and storing the count in the storage unit.

Abstract: The object is to provide a novel organism identification method which can be used as an alternative method to a conventional organism identification method which utilizes DNA and requires enormous labor. Developed is an organism identification method for determining whether or not an organism of interest is identical to a specific organism or a progeny thereof, which is characterized by introducing a DNA tag(s) in advance into a cell(s) of the specific organism, or a parasite or a symbiont with the specific organism, and determining whether or not the organism of interest is identical to the specific organism or a progenitor thereof based on the detection or non-detection of the DNA tag in DNA extracted from the organism of interest, or the parasite or the symbiont with the organism of interest.

Abstract: The present invention relates to a biological-information processing apparatus and a method, which are capable of measuring a hybridisation of a DMA chip without making use of a complex measurement configuration, at a low cost and with a high degree of accuracy, as well as relates to a program and a recording medium. An area enclosed by a spot boundary 461 is divided into spot internal areas 522 each having debris 463 and spot internal areas 521 each having no debris 463. For each of the spot internal areas 521 and 522, a flag f is set in accordance with the reliability of each of the spot internal areas 521 and 522 respectively in order to prevent data of a spot internal area having low reliability from being used. The present invention can be applied to an apparatus for measuring the fluorescence intensity of the DNA chip.

Abstract: The present invention provides a method of testing whether a sequence of interest is contained in a sample nucleic acid or not, comprising performing a simple test on the sample nucleic acid and subjecting the same sample nucleic acid to a close examination when it has been judged that the sequence of interest is contained therein or when it has been judged that the sequence of interest is not contained therein; and a method of testing whether a sequence of interest is contained in a sample nucleic acid in more than a specific amount or not, comprising performing a simple quantitative test on the sample nucleic acid and subjecting the same sample nucleic acid to a close examination when it has been judged that the sequence of interest is contained therein in more than the specific amount. According to these methods, it becomes possible to examine individuals, species, habitats, etc. of organisms with much higher reliability than that in conventional techniques.

Abstract: Disclosed herein is a method and apparatus for determining the base sequence of a nucleic acid molecule by cleaving a nucleic acid molecule of interest while controlling the cleavage site, measuring the change in mass which occurs in the nucleic acid molecule after the cleavage step, and acquiring the base information of the cleaved nucleic acid molecule from the data about the change in mass. The method and apparatus are based on the principle which is entirely different from that used for the conventional technique.

Abstract: Disclosed herein is a method and apparatus for determining the base sequence of a nucleic acid molecule by cleaving a nucleic acid molecule of interest while controlling the cleavage site, measuring the change in mass which occurs in the nucleic acid molecule after the cleavage step, and acquiring the base information of the cleaved nucleic acid molecule from the data about the change in mass. The method and apparatus are based on the principle which is entirely different from that used for the conventional technique.

Abstract: The present invention aims at producing a biochip by an inkjet system without wasting a DNA solution. A biochip-producing solution is prepared to contain a combination of a DNA solution 6 to be spotted on a plate 5 and a low-cost buffer solution 7 to be remained in the device after the production. The buffer solution 7 used has a different specific gravity from that of the DNA solution 6 and thus is not mixed therewith.

Abstract: For comparatively displaying the abundances of a large number of biopolymer species as measured in two different samples in an efficient and distinguishable manner, the values measured for biopolymer abundances in the two samples are normalized so that the sum totals of the measured values as calculated for both samples become equal to each other and the biopolymer abundance ratios between both samples are displayed in the form of a line graph, with the ordinate (logarithmic scale axis) denoting the abundance ratio for each biopolymer between both samples and the abscissa denoting the biopolymer species. On the same graph, the sum of abundances of each biopolymer in both samples may also be displayed along the Y axis as a second axis.

Abstract: The present invention aims at producing a biochip by an inkjet system without wasting a DNA solution.