Patents by Inventor Atsushi Enomoto

Atsushi Enomoto has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20230301950
    Abstract: The present invention provides a method for selecting a cancer patient for whom a combination therapy with a retinoid and a cancer treatment agent is effective, which comprises a step of selecting a cancer patient having a malignant tumor with the infiltration of cancer-associated fibroblasts in the stroma. In addition, the present invention provides a medicament which comprises a cancer patient having a malignant tumor with the infiltration of cancer-associated fibroblasts in the stroma is a subject and is administered in combination of a retinoid and a cancer therapeutic agent.
    Type: Application
    Filed: June 28, 2021
    Publication date: September 28, 2023
    Applicant: RaQualia Pharma Inc.
    Inventors: Tadashi IIDA, Atsushi ENOMOTO, Yasuyuki MIZUTANI, Masahide TAKAHASHI, Mitsuhiro FUJISHIRO, Hiroki KAWASHIMA, Yoshihisa MATSUKAWA, Takayuki OWAKI
  • Publication number: 20230289851
    Abstract: An information management apparatus, comprising a transmitting unit that transmits service information on a given service to a plurality of users, and a calculation unit that for each of the users of the service, calculates a degree of familiarity with a given dealer as to the service, wherein the service information includes sub-information for each of the users to use to proceed with a procedure for receiving the service, the calculation unit calculates the degree of familiarity, based on a communication history of the user, and the transmitting unit transmits the sub-information to a user whose degree of familiarity is lower than a reference value, and inhibits transmission of the sub-information to a user whose degree of familiarity is higher than the reference value.
    Type: Application
    Filed: February 17, 2023
    Publication date: September 14, 2023
    Applicant: HONDA MOTOR CO., LTD.
    Inventors: Yoshihiro Deguchi, Atsushi Enomoto
  • Publication number: 20230084099
    Abstract: An anti-MEFLIN antibody and a pharmaceutical composition comprising the antibody is described. The pharmaceutical composition may comprise an antibody-drug conjugate (ADC) of the anti-MEFLIN antibody and a cytotoxic agent, which may be connected to each other by a linker. The pharmaceutical composition may be used in the treatment of a cancer in a subject.
    Type: Application
    Filed: February 3, 2021
    Publication date: March 16, 2023
    Applicants: National University Corporation Tokai National Higher Education and Research System, Sowakai Medical Foundation
    Inventors: Atsushi ENOMOTO, Nobutoshi ESAKI, Masahide TAKAHASHI, Yuki MIYAI, Ryota ANDO, Yukihiro SHIRAKI, Yoshihiro NISHIDA, Makoto MATSUYAMA, Shino MANABE
  • Publication number: 20210002714
    Abstract: An object of the present invention is to provide a novel marker that can be used to predict the effect of anti-PD-1 antibody/anti-PD-L1 antibody therapy with high sensitivity, and use thereof. Provided is a biomarker for predicting the effect of anti-PD-1 antibody/anti-PD-L1 antibody therapy, including an immunoglobulin superfamily containing leucine-rich repeat (ISLR).
    Type: Application
    Filed: February 7, 2019
    Publication date: January 7, 2021
    Inventors: Yuki Miyai, Atsushi Enomoto, Masahide Takahashi, Yoshinori Hasegawa, Tetsunari Hase, Yuichi Ando
  • Patent number: 10398134
    Abstract: Provided are a knockout mouse, a method for screening a substance for suppressing mesial temporal lobe epilepsy, and a method for selecting a technique for suppressing mesial temporal lobe epilepsy. A knockout mouse 30 or more days of age that has lost the function of the Girdin gene in at least the nervous tissues and exhibits the phenotypes of (1), (2), and (3) below. (1) hippocampal sclerosis should be present, (2) extrahippocampal brain damage should be limited, and (3) spontaneous epilepsy that can be said to be of hippocampal origin should be present.
    Type: Grant
    Filed: October 13, 2015
    Date of Patent: September 3, 2019
    Assignee: NATIONAL UNIVERSITY CORPORATION NAGOYA UNIVERSITY
    Inventors: Masato Asai, Masahide Takahashi, Naoya Asai, Atsushi Enomoto, Kozo Uchiyama
  • Publication number: 20170223937
    Abstract: Provided are a knockout mouse, a method for screening a substance for suppressing mesial temporal lobe epilepsy, and a method for selecting a technique for suppressing mesial temporal lobe epilepsy. A knockout mouse 30 or more days of age that has lost the function of the Girdin gene in at least the nervous tissues and exhibits the phenotypes of (1), (2), and (3) below. (1) hippocampal sclerosis should be present, (2) extrahippocampal brain damage should be limited, and (3) spontaneous epilepsy that can be said to be of hippocampal origin should be present.
    Type: Application
    Filed: October 13, 2015
    Publication date: August 10, 2017
    Inventors: Masato ASAI, Masahide TAKAHASHI, Naoya ASAI, Atsushi ENOMOTO, Kozo UCHIYAMA
  • Patent number: 9372189
    Abstract: The purpose of the present invention is to provide: a biomarker specific to lymphocytic infundibuloneurohypophysitis; and use applications of the biomarker. Provided are: a biomarker comprising an anti-rabphilin 3a antibody; and a test method using the biomarker.
    Type: Grant
    Filed: November 16, 2012
    Date of Patent: June 21, 2016
    Assignee: NATIONAL UNIVERSITY CORPORATION NAGOYA UNIVERSITY
    Inventors: Yoshihisa Sugimura, Yutaka Oiso, Shintaro Iwama, Atsushi Enomoto, Takuya Kato
  • Publication number: 20160041176
    Abstract: Antibodies are provided that specifically bind to Acting Binding Protein Girdin (Akt Phosphorylation Enhancer), a new substrate of serine/threonine kinase. Additionally, methods of making hybridomas for producing said antibodies and methods of detecting girdin using said antibodies are provided herein. The antibodies and methods are useful for detecting girdin in tissue samples, such as tissue samples from subjects having or suspected of having a disorder in which any of cell motility, cell movement, and angiogenesis is involved.
    Type: Application
    Filed: October 21, 2015
    Publication date: February 11, 2016
    Inventors: Masahide Takahashi, Atsushi Enomoto, Toyoaki Murohara
  • Patent number: 9206242
    Abstract: It is intended to identity a protein involved in a molecular mechanism between Akt and cell motility as well as to elucidate its function and find its application. In the present teachings, for achieving the above object, protein or partial peptide thereof containing an amino acid sequence identical or substantially identical to the amino acid sequence represented by SEQ ID: 2 is utilized in the screening of a compound or a salt thereof that activates or inhibits any of cell motility, cell migration and angiogenesis.
    Type: Grant
    Filed: November 10, 2006
    Date of Patent: December 8, 2015
    Assignee: NATIONAL UNIVERSITY CORPORATION NAGOYA UNIVERSITY
    Inventors: Masahide Takahashi, Atsushi Enomoto
  • Publication number: 20150160209
    Abstract: The purpose of the present invention is to provide: a biomarker specific to lymphocytic infundibuloneurohypophysitis; and use applications of the biomarker. Provided are: a biomarker comprising an anti-rabphilin 3a antibody; and a test method using the biomarker.
    Type: Application
    Filed: November 16, 2012
    Publication date: June 11, 2015
    Applicant: NATIONAL UNIVERSITY CORPORATION NAGOYA UNIVERSITY
    Inventors: Yoshihisa Sugimura, Yutaka Oiso, Shintaro Iwama, Atsushi Enomoto, Takuya Kato
  • Publication number: 20100050278
    Abstract: It is intended to identity a protein involved in a molecular mechanism between Akt and cell motility as well as to elucidate its function and find its application. In the present teachings, for achieving the above object, protein or partial peptide thereof containing an amino acid sequence identical or substantially identical to the amino acid sequence represented by SEQ ID: 2 is utilized in the screening of a compound or a salt thereof that activates or inhibits any of cell motility, cell migration and angiogenesis.
    Type: Application
    Filed: November 10, 2006
    Publication date: February 25, 2010
    Applicant: NATIONAL UNIVERSITY CORPORATION NAGOYA UNIVERSITY
    Inventors: Masahide Takahashi, Atsushi Enomoto, Toyoaki Murohara
  • Patent number: 7582447
    Abstract: It is intended to identify and provide a novel carnitine transporter gene participating in carnitine transport in the testis and epididymis and carnitine transporter which is a protein encoded by the gene. A protein comprising the amino acid sequence represented by SEQ ID NO: 2 or an amino acid sequence derived therefrom by deletion, substitution or addition of one to several amino acids and being capable of transporting carnitine or its analog; and a gene encoding this protein.
    Type: Grant
    Filed: July 3, 2007
    Date of Patent: September 1, 2009
    Assignee: Human Cell Systems, Inc.
    Inventors: Hitoshi Endou, Yoshikatsu Kanai, Atsushi Enomoto
  • Patent number: 7510847
    Abstract: It is intended to identify and provide a novel urate transporter gene participating in the urate transport in the kidney and a urate transporter which is a polypeptide encoded by the above gene. Namely, a protein comprising the amino acid sequence represented by SEQ ID NO:1 or an amino acid sequence derived therefrom by deletion, substitution or addition of one to several amino acids and being capable of transporting uric acid and its analogs; and a gene encoding this protein.
    Type: Grant
    Filed: December 21, 2006
    Date of Patent: March 31, 2009
    Assignee: Human Cell Systems, Inc.
    Inventors: Hitoshi Endou, Yoshikatsu Kanai, Atsushi Enomoto
  • Publication number: 20080050811
    Abstract: It is intended to identify and provide a novel carnitine transporter gene participating in carnitine transport in the testis and epididymis and carnitine transporter which is a protein encoded by the gene. A protein comprising the amino acid sequence represented by SEQ ID NO:1 or an amino acid sequence derived therefrom by deletion, substitution or addition of one to several amino acids and being capable of transporting carnitine or its analog; and a gene encoding this protein.
    Type: Application
    Filed: July 3, 2007
    Publication date: February 28, 2008
    Applicant: Human Cell Systems, Inc.
    Inventors: Hitoshi Endou, Yoshikatsu Kanai, Atsushi Enomoto
  • Patent number: 7281578
    Abstract: A borehole tool positioning and measuring apparatus and its methods of use are provided. The apparatus and method can be used to centralize a logging tool in a wellbore, or position a logging tool at a desired relative alignment relative to the wellbore perimeter surface. The method and apparatuses can be used to determine useful information regarding borehole size and configuration. Various embodiments are useful for centralizing, eccentralizing, and otherwise positioning a borehole tool in a wellbore. Methods of determining borehole size and configuration measurements using a positioning apparatus are also provided.
    Type: Grant
    Filed: June 18, 2004
    Date of Patent: October 16, 2007
    Assignee: Schlumberger Technology Corporation
    Inventors: Hiroshi Nakajima, Atsushi Enomoto
  • Patent number: 7244556
    Abstract: It is intended to identify and provide a novel carnitine transporter gene participating in carnitine transport in the testis and epididymis and carnitine transporter which is a protein encoded by the gene. A protein comprising the amino acid sequence represented by SEQ ID NO:2 or an amino acid sequence derived therefrom by deletion, substitution or addition of one to several amino acids and being capable of transporting carnitine or its analog; and a gene encoding this protein.
    Type: Grant
    Filed: May 27, 2002
    Date of Patent: July 17, 2007
    Assignee: Human Cell Systems, Inc.
    Inventors: Hitoshi Endou, Yoshikatsu Kanai, Atsushi Enomoto
  • Publication number: 20070117162
    Abstract: It is intended to identify and provide a novel urate transporter gene participating in the urate transport in the kidney and a urate transporter which is a polypeptide encoded by the above gene. Namely, a protein comprising the amino acid sequence represented by SEQ ID NO: 1 or an amino acid sequence derived therefrom by deletion, substitution or addition of one to several amino acids and being capable of transporting uric acid and its analogs; and a gene encoding this protein.
    Type: Application
    Filed: December 21, 2006
    Publication date: May 24, 2007
    Applicant: Human Cell Systems, Inc.
    Inventors: Hitoshi Endou, Yoshikatsu Kanai, Atsushi Enomoto
  • Publication number: 20050279498
    Abstract: A borehole tool positioning and measuring apparatus and its methods of use are provided. The apparatus and method can be used to centralize a logging tool in a wellbore, or position a logging tool at a desired relative alignment relative to the wellbore perimeter surface. The method and apparatuses can be used to determine useful information regarding borehole size and configuration. Various embodiments are useful for centralizing, eccentralizing, and otherwise positioning a borehole tool in a wellbore. Methods of determining borehole size and configuration measurements using a positioning apparatus are also provided.
    Type: Application
    Filed: June 18, 2004
    Publication date: December 22, 2005
    Inventors: Hiroshi Nakajima, Atsushi Enomoto
  • Publication number: 20050054035
    Abstract: It is intended to identify and provide a novel carnitine transporter gene participating in carnitine transport in the testis and epididymis and carnitine transporter which is a protein encoded by the gene. A protein comprising the amino acid sequence represented by SEQ ID NO: 2 or an amino acid sequence derived therefrom by deletion, substitution or addition of one to several amino acids and being capable of transporting carnitine or its analog; and a gene encoding this protein.
    Type: Application
    Filed: May 27, 2002
    Publication date: March 10, 2005
    Inventors: Hitoshi Endou, Yoshikatsu Kanai, Atsushi Enomoto
  • Publication number: 20040265819
    Abstract: It is intended to identify and provide a novel urate transporter gene participating in the urate transport in the kidney and a urate transporter which is a polypeptide encoded by the above gene. Namely, a protein comprising the amino acid sequence represented by SEQ ID NO:1 or an amino acid sequence derived therefrom by deletion, substitution or addition of one to several amino acids and being capable of transporting uric acid and its analogs; and a gene encoding this protein.
    Type: Application
    Filed: January 29, 2004
    Publication date: December 30, 2004
    Inventors: Hitoshi Endou, Yoshikatsu Kanai, Atsushi Enomoto