Patents by Inventor Atsushi Kajiyama
Atsushi Kajiyama has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 7189415Abstract: The present invention relates to a pharmaceutical composition useful for rapid disintegration, which comprises a sparingly soluble medicament held on a gel-forming water-soluble polymer as a solid dispersion, wherein it contains a salt substance that comprises an alkali and a weak or strong acid and has an endothermic standard enthalpy of solution or heat of solution. Since rapid disintegration of the pharmaceutical composition of the present invention and rapid dissolution of the medicament contained in the preparation can be made in the digestive tracts pH-independently, good bioavailability can be attained.Type: GrantFiled: November 30, 2004Date of Patent: March 13, 2007Assignee: Astellas Pharma Inc.Inventors: Hirokazu Takagi, Atsushi Kajiyama, Masahiro Yanagisawa
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Publication number: 20070014856Abstract: The present invention relates to a pharmaceutical composition useful for rapid disintegration, which comprises a sparingly soluble medicament held on a gel-forming water-soluble polymer as a solid dispersion, wherein it contains a salt substance that comprises an alkali and a weak or strong acid and has an endothermic standard enthalpy of solution or heat of solution. Since rapid disintegration of the pharmaceutical composition of the present invention and rapid dissolution of the medicament contained in the preparation can be made in the digestive tracts pH-independently, good bioavailability can be attained.Type: ApplicationFiled: September 19, 2006Publication date: January 18, 2007Inventors: Hirokazu Takagi, Atsushi Kajiyama, Masahiro Yanagisawa
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Patent number: 6899899Abstract: The present invention relates to a pharmaceutical composition useful for rapid disintegration, which comprises a sparingly soluble medicament held on a gel-forming water-soluble polymer as a solid dispersion, wherein it contains a salt substance that comprises an alkali and a weak or strong acid and has an endothermic standard enthalpy of solution or heat of solution. Since rapid disintegration of the pharmaceutical composition of the present invention and rapid dissolution of the medicament contained in the preparation can be made in the digestive tracts pH-independently, good bioavailability can be attained.Type: GrantFiled: July 9, 2002Date of Patent: May 31, 2005Assignee: Yamanouchi Pharmaceutical Co., Ltd.Inventors: Hirokazu Takagi, Atsushi Kajiyama, Masahiro Yanagisawa
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Publication number: 20050100598Abstract: The present invention relates to a quick disintegrating tablet in buccal cavity, comprising: a mixture, comprising a drug, a sugar (A), and an amorphous sugar (B), and after it is forming a tablet, it is humidified and dried. In particularly, the present invention relates to a quick disintegrating tablet in buccal cavity comprising: a mixture; comprising a drug, a sugar (A), and an amorphous sugar (B) which an amorphous-forming sugar in crystalline state is dissolved in a medicinally permitted solvent, the amorphous sugar is obtained from this solution by removing the solvent, and after it is forming a tablet, and it is humidified and dried. The tablet in the present invention is to provide stability against moisture at preserved, because the amorphous sugar changed to the crystalline state in a nonreversible reaction after it is humidified and dried in a manufacturing process.Type: ApplicationFiled: October 7, 2004Publication date: May 12, 2005Applicants: Yamanouchi Pharma Technologies, Inc.Inventors: Takao Mizumoto, Yoshinori Masuda, Atsushi Kajiyama, Masahiro Yanagisawa, Janaki Ram Nyshadham
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Publication number: 20050095289Abstract: The present invention relates to a pharmaceutical composition useful for rapid disintegration, which comprises a sparingly soluble medicament held on a gel-forming water-soluble polymer as a solid dispersion, wherein it contains a salt substance that comprises an alkali and a weak or strong acid and has an endothermic standard enthalpy of solution or heat of solution. Since rapid disintegration of the pharmaceutical composition of the present invention and rapid dissolution of the medicament contained in the preparation can be made in the digestive tracts pH-independently, good bioavailability can be attained.Type: ApplicationFiled: November 30, 2004Publication date: May 5, 2005Inventors: Hirokazu Takagi, Atsushi Kajiyama, Masahiro Yanagisawa
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Patent number: 6803054Abstract: The present invention relates to a quick disintegrating tablet in buccal cavity, comprising: a mixture, comprising a drug, a sugar (A), and an amorphous sugar (B), and after it is forming a tablet, it is humidified and dried. In particularly, the present invention relates to a quick disintegrating tablet in buccal cavity comprising: a mixture; comprising a drug, a sugar (A), and an amorphous sugar (B) which an amorphous-forming sugar in crystalline state is dissolved in a medicinally permitted solvent, the amorphous sugar is obtained from this solution by removing the solvent, and after it is forming a tablet, and it is humidified and dried. The tablet in the present invention is to provide stability against moisture at preserved, because the amorphous sugar changed to the crystalline state in a nonreversible reaction after it is humidified and dried in a manufacturing process.Type: GrantFiled: June 2, 2003Date of Patent: October 12, 2004Assignees: Yamanouchi Pharmaceutical Co., Ltd., Yamanouchi Pharma Technologies, Inc.Inventors: Takao Mizumoto, Yoshinori Masuda, Atsushi Kajiyama, Masahiro Yanagisawa, Janaki Ram Nyshadham
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Publication number: 20030203022Abstract: The present invention relates to a quick disintegrating tablet in buccal cavity, comprising: a mixture, comprising a drug, a sugar (A), and an amorphous sugar (B), and after it is forming a tablet, it is humidified and dried. In particularly, the present invention relates to a quick disintegrating tablet in buccal cavity comprising: a mixture; comprising a drug, a sugar (A), and an amorphous sugar (B) which an amorphous-forming sugar in crystalline state is dissolved in a medicinally permitted solvent, the amorphous sugar is obtained from this solution by removing the solvent, and after it is forming a tablet, and it is humidified and dried.Type: ApplicationFiled: June 2, 2003Publication date: October 30, 2003Applicants: Yamanouchi Pharmaceutical Co., Ltd., Yamanouchi Pharma Technologies, Inc.Inventors: Takao Mizumoto, Yoshinori Masuda, Atsushi Kajiyama, Masahiro Yanagisawa, Janaki Ram Nyshadham
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Patent number: 6589554Abstract: The present invention relates to a quick disintegrating tablet in buccal cavity, comprising: a mixture, comprising a drug, a sugar (A), and an amorphous sugar (B), and after it is forming a tablet, it is humidified and dried. In particularly, the present invention relates to a quick disintegrating tablet in buccal cavity comprising: a mixture; comprising a drug, a sugar (A), and an amorphous sugar (B) which an amorphous-forming sugar in crystalline state is dissolved in a medicinally permitted solvent, the amorphous sugar is obtained from this solution by removing the solvent, and after it is forming a tablet, and it is humidified and dried. The tablet in the present invention is to provide stability against moisture at preserved, because the amorphous sugar changed to the crystalline state in a nonreversible reaction after it is humidified and dried in a manufacturing process.Type: GrantFiled: September 14, 2000Date of Patent: July 8, 2003Assignees: Yamanouchi Pharmaceutical Co., Ltd., Yamanouchi Pharma Technologies, Inc.Inventors: Takao Mizumoto, Yoshinori Masuda, Atsushi Kajiyama, Masahiro Yanagisawa, Janaki Ram Nyshadham
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Publication number: 20030003146Abstract: The present invention relates to a pharmaceutical composition useful for rapid disintegration, which comprises a sparingly soluble medicament held on a gel-forming water-soluble polymer as a solid dispersion, wherein it contains a salt substance that comprises an alkali and a weak or strong acid and has an endothermic standard enthalpy of solution or heat of solution. Since rapid disintegration of the pharmaceutical composition of the present invention and rapid dissolution of the medicament contained in the preparation can be made in the digestive tracts pH-independently, good bioavailability can be attained.Type: ApplicationFiled: July 9, 2002Publication date: January 2, 2003Applicant: YAMANOUCHI PHARMACEUTICAL CO., LTD.Inventors: Hirokazu Takagi, Atsushi Kajiyama, Masahiro Yanagisawa
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Publication number: 20020031547Abstract: The present invention relates to a pharmaceutical composition useful for rapid disintegration, which comprises a sparingly soluble medicament held on a gel-forming water-soluble polymer as a solid dispersion, wherein it contains a salt substance that comprises an alkali and a weak or strong acid and has an endothermic standard enthalpy of solution or heat of solution. Since rapid disintegration of the pharmaceutical composition of the present invention and rapid dissolution of the medicament contained in the preparation can be made in the digestive tracts pH-independently, good bioavailability can be attained.Type: ApplicationFiled: June 18, 1999Publication date: March 14, 2002Applicant: YAMANOUCHI PHARMACEUTICAL CO., LTD.Inventors: HIROKAZU TAKAGI, ATSUSHI KAJIYAMA, MASAHIRO YANAGISAWA
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Patent number: 5258186Abstract: A coating material for controlling drug release, useful for long acting formulations--e.g. for once-a-day administration, and to a long acting granular composition comprising a drug (especially one conventionally difficult to prepare in long acting form) coated with the coating material. This composition may be mixed with other granular drug formulations. The drug-release controlling coating material comprising, in a specific ratio, one specific water-insoluble and low water-permeability polymers and two materials differing from each other in the pH-dependency of their solubility (pH-dependent polymer-materials).Type: GrantFiled: May 18, 1992Date of Patent: November 2, 1993Assignee: Yamanouchi Pharmaceutical Co., Ltd.Inventors: Tadayoshi Ohmura, Muneo Fukui, Hiroshi Sugiura, Satoru Yoneya, Toshiharu Hosono, Atsushi Kajiyama
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Patent number: 5028664Abstract: A coating material for controlling drug release, useful for long acting formulations--e.g. for once-a-day administration, and to a long acting granular composition comprising a drug (especially one conventionally difficult to prepare in long acting form) coated with the coating material. This composition may be mixed with other granular drug formulations. The drug-release controlling coating material comprising, in a specific ration, one specific water-insoluble and low water-permeability polymers and two materials differing from each other in the pH-dependency of their solubility (pH-dependent polymer-materials).Type: GrantFiled: March 8, 1990Date of Patent: July 2, 1991Assignee: Yamanouchi Pharmaceutical Co., Ltd.Inventors: Tadayoshi Ohmura, Muneo Fukui, Hiroshi Sugiura, Satoru Yoneya, Toshiharu Hosono, Atsushi Kajiyama
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Patent number: 4772475Abstract: A pharmaceutical controlled-release individual unit or multiple units formulation in which the individual unit comprises a granulation product obtained by adding a release controlling agent to a mixture of a physiologically active substance and units-forming substance(s) and granulating and resultant mixture, said granulation product (granules) being substantially not disintegrated but gradually releasing the physiologically active substance in the gastrointestinal tract.Type: GrantFiled: February 27, 1986Date of Patent: September 20, 1988Assignee: Yamanouchi Pharmaceutical Co., Ltd.Inventors: Muneo Fukui, Kouji Tomuro, Shigeru Masuyama, Atsushi Kajiyama, Tamio Hikosaka, Masayoshi Aruga, Saburo Higuchi, Yoshiaki Soeishi