Abstract: The present invention provides a method for culturing odontoma cells or normal cells, wherein these cells are cultured in the presence of a Rho kinase inhibitor.

Abstract: Provided is a method of determining a therapeutic effect of cancer chemotherapy with an anticancer drug obtained by blending three ingredients, i.e., tegafur, gimeracil, and oteracil potassium as active ingredients (hereinafter abbreviated as S-1) quickly, simply, and accurately before carrying out the cancer chemotherapy. Specifically, provided is a method of determining an administration effect in chemotherapy with S-1, the method comprising: a step (a) of measuring expression level of a decorin gene in a biological sample collected from a subject to be diagnosed; and a step (b) of determining an administration effect of S-1 based on the expression level of the gene obtained from the measurement.

Abstract: A wire harness including a wire fitting is provided that maintains the length of the portion of the wire bundle that extends to the outside of the wire fitting reliably at a tolerance range without impeding the freedom of bending the wire bundle. A wire harness includes a wire fitting having a base and a cover covering a portion of a wire bundle together with the base. The base is provided with a protrusion that pierces the insulated wires at a portion further to an outer edge of the base than a portion of the wire bundle that is tied together by a first tie member, the wire bundle extending from the base to an outside of the base.

Abstract: Provided is a method of determining a therapeutic effect of cancer chemotherapy with an anticancer drug obtained by blending three ingredients, i.e., tegafur, gimeracil, and oteracil potassium as active ingredients (hereinafter abbreviated as S-1) quickly, simply, and accurately before carrying out the cancer chemotherapy. Specifically, provided is a method of determining an administration effect in chemotherapy with S-1, the method comprising: a step (a) of measuring expression level of a decorin gene in a biological sample collected from a subject to be diagnosed; and a step (b) of determining an administration effect of S-1 based on the expression level of the gene obtained from the measurement.

Abstract: A wiring tool (10) includes a base (1) and a cover (2) each of which is a plate with projections and recesses. The base (1) has partition walls (12A, 12B) standing from a wiring portion (11) to surround protection spaces (90A, 90B) where protected portions (41, 42) are to be arranged. The cover (2) is assembled with the base (1) to cover an area of the base (1) including the wiring portion (11). The cover (2) includes lids (24) that project toward the base (1) and fit into the inner sides of the partition walls (12A, 12B) of the base (1) to close openings formed by the partition walls (12A, 12B). The base (1) and the cover (2) are obtained by vacuum forming a flat resin plate.

Abstract: A wiring tool for holding wires has a plate-like member with connector support (15) that supports a connector (91) by engaging a coupling portion (92) of the connector (91). The connector support (15) has two parallel recesses (151) that form parallel grooves extending straight in from an outer edge of the plate-like member. Two parallel projections (921) of the coupling (92) are fit into the grooves. An intermediate plate (152) of the connector support (15) is between the parallel recesses (151) and is inserted into a clearance between the outer surface of the connector (91) and a beam (922) of the coupling (92). The intermediate plate (152) has a hole (153) that engages a facing projection (923) formed on the beam (922).

Abstract: This disclosure provides methods for catalyzing the release of ADP-ribose from poly(ADP-ribose) or O-acetyl-ADP-ribose. Also provided are methods for modifying DNA repair or chromatin structure by introducing into the cell an agent that modifies the activity of an ARH3 polypeptide, or variant or fragment thereof. Further provided are methods for screening molecules involved in the poly(ADP-ribosyl)ation of proteins or O-acetyl-ADP-ribose content, and method for treating disorders by altering activity of an ARH3 protein.

Abstract: This disclosure provides methods for catalyzing the release of ADP-ribose from poly(ADP-ribose) or O-acetyl-ADP-ribose. Also provided are methods for modifying DNA repair or chromatin structure by introducing into the cell an agent that modifies the activity of an ARH3 polypeptide, or variant or fragment thereof. Further provided are methods for screening molecules involved in the poly(ADP-ribosyl)ation of proteins or O-acetyl-ADP-ribose content, and method for treating disorders by altering activity of an ARH3 protein.