Abstract: The present disclosure provides novel pladienolide compounds, pharmaceutical compositions containing such compounds, and methods for using the compounds as therapeutic agents. These compounds may be useful in the treatment of cancers, particularly cancers in which agents that target the spliceosome and mutations therein are known to be useful. Also provided herein are methods of treating cancers by administering at least one compound disclosed herein and at least one additional therapy.

Abstract: The present invention has its object to provide a polyester resin composition which can give molded articles which even upon exposure to elevated temperatures, will not lose their surface gloss and will show little warping and are high in elastic modulus and thermal stability. Molding a polyester resin composition which comprises a polyalkylene terephthalate resin having an acid value of not higher than 30 ?eq/g and a layered compound can make it possible to obtain the molded articles having the above-mentioned properties.

Abstract: An object of the present invention is to provide a polyamide resin composition having high mechanical properties and high heat resistance while achieving a satisfactory balance between various physical properties. A molded product made of this polyamide resin exhibits a lower warpage and excellent surface appearance. A method for producing the polyamide, resin composition is also provided. The present invention provides a polyamide resin composition containing a polyamide resin and swelling mica treated with a polyether compound having a bisphenol structure. The present invention also provides a method for making the polyamide resin composition including melt-mixing a polyamide resin with a polyether compound.

Abstract: An object of the present invention is to provide a polyamide resin composition having high mechanical properties and high heat resistance while achieving a satisfactory balance between various physical properties. A molded product made of this polyamide resin exhibits a lower warpage and excellent surface appearance. A method for producing the polyamide, resin composition is also provided. The present invention provides a polyamide resin composition containing a polyamide resin and swelling mica treated with a polyether compound having a bisphenol structure. The present invention also provides a method for making the polyamide resin composition including melt-mixing a polyamide resin with a polyether compound.

Abstract: A vehicular pillar cover which is drastically improved in a performance for absorbing and damping an impact. The vehicular pillar cover comprises ribs (3a and 3b) staggered in a body (2) having a generally C-shaped or folded section, at a suitable spacing, and so extended generally at a right angle with respect to the longitudinal direction of the body (2) from the individual side wall portions (2a and 2b) of the body (2) as to form gaps between the opposed side wall portions and cut-off portions (4a and 4b) in the upper faces of the ribs (3a and 3b) and along the inner side shape of the body (2).