Patents by Inventor Attila Csehi

Attila Csehi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 5589486
    Abstract: The invention relates to novel N-hydroxy-substituted 1,2,3,6-tetrahydropyridine and piperidine derivatives of the formula ##STR1## wherein A, B, D, E, G, I and R are as defined in the specification, m is 0, 1 or 2, with the proviso that:m is 0 or 2, or both G and I are hydrogen, when A is benzyl or halogen-monosubstituted benzyl group; andm is 1, when A is 2-picolyl, as well as their pharmaceutically acceptable acid addition salts. The compounds of formula (I) are useful for enhancing the tolerance of mammals (including man) against hypoxic and/or ischaemic states as well as for treating the degenerative and functional disturbances arising from hypoxic and/or ischaemic results.
    Type: Grant
    Filed: January 17, 1995
    Date of Patent: December 31, 1996
    Assignee: Richter Gedeon Vegyeszeti Gyar Rt.
    Inventors: Kalman Harsanyi, Tibor Gizur, Eva Agai-Csongor, Anna Kallai-Sohonyai, Marta Kapolnas-Pap, Eva Csizer, Bela Heged us, Laszlo Szporny, Bela Kiss, Egon Karpati, Eva Palosi, Zsolt Szombathelyi, Adam Sarkadi, Aniko Gere, Mihaly Bodo, Katalin Csomor, Judit Laszy, Zsolt Szentirmai, Erzsebet Lapis, Sandor Szabo, Peter Bod, Attila Csehi
  • Patent number: 5583138
    Abstract: The invention relates to novel 17.beta.-substituted 4-azaandrostane derivatives of general formula (I), ##STR1## wherein R means hydrogen or a C.sub.1-3 alkyl group;R.sup.1 and R.sup.2 are the same or different and stand for hydrogen or a C.sub.1-4 alkyl group with the proviso that both can mean hydrogen only in the case when n is higher than 5; orR.sup.1 and R.sup.2 together means an .alpha.,.omega.-alkylene group containing 5 to 7 carbon atoms, the terminal carbon atoms of said alkylene group being bound to the same ring carbon atom;n is 4, 5, 6 or 7; and--- bond line represents a single or double bond.Furthermore, the invention relates to pharmaceutical composition containing these compounds as well as a process for the preparation of the compounds of general formula (I).The compounds of general formula (I) exert a 5.alpha.
    Type: Grant
    Filed: March 23, 1995
    Date of Patent: December 10, 1996
    Assignee: Richter Gedeon Vegyeszeti Gyar Rt.
    Inventors: Zolt an Tuba, Judit Horv ath, L aszl o Koll ar, M aria Lovas n ee Marsai, G abor Balogh, Attila Csehi, Andr as J avor, Gy orgy Hajo os, L aszl o Szporny
  • Patent number: 5478949
    Abstract: The invention relates to carbazolone derivatives of the formula ##STR1## wherein A stands for a group of formula--CH.sub.2 --R (V),wherein R means a hydroxyl or 2-methyl-1H-imidazol-1-yl group;B represents a group of formula ##STR2## wherein R.sub.1 means hydrogen or a methyl or ethyl group; or A and B together form a group of formula ##STR3## wherein R.sub.2 means a methyl or ethyl group; or A and B together form a group of formula ##STR4## The above compounds are useful intermediates in the synthesis of ondansetron of formula ##STR5## chemically 9-methyl-3-[(2-methyl-1H-imidazol-1-yl)methyl]-1,2,3,9-tetrahydro-4H-carba zol-4-one.The invention further relates to a novel process for the preparation of compounds of the formula (I) , wherein A and B are the same as in formula (I) but B may be also hydrogen. Thus, this novel process is suitable for the preparation of ondansetron itself.
    Type: Grant
    Filed: November 25, 1994
    Date of Patent: December 26, 1995
    Assignee: Richter Gedeon Vegyeszeti Gyar Rt.
    Inventors: Peter Bod, Kalman Harsanyi, Ferenc Trischler, Eva Fekecs, Attila Csehi, Bela Hegedus, Eva Mersich nee Donat, Gyorgyi Szabo nee Komlosi, Erika Horvath nee Sziki
  • Patent number: 5416221
    Abstract: The invention relates to carbazolone derivatives of the formula ##STR1## wherein A stands for a group of formula--CH.sub.2 --R (V),wherein R means a hydroxyl or 2-methyl-1H-imidazol-1-yl group;B represents a group of formula ##STR2## wherein R.sub.1 means hydrogen or a methyl or ethyl group; or A and B together form a group of formula ##STR3## wherein R.sub.2 means a methyl or ethyl group; or A and B together form a group of formula ##STR4## The above compounds are useful intermediates in the synthesis of ondansetron of formula ##STR5## chemically 9-methyl-3-[(2-methyl)-1H-imidzol-1-yl)methyl]1,2,3,9-tetrahydro-4H-carbaz ol-4-one.The invention further relates to a novel process for the preparation of compounds of the formula (I), wherein A and B are the same as in formula (I) but B may be also hydrogen. Thus, this novel process is suitable for the preparation of ondansetron itself.
    Type: Grant
    Filed: October 13, 1993
    Date of Patent: May 16, 1995
    Inventors: Peter Bod, Kalman Harsanyi, Ferenc Trischler, Eva Fekecs, Attila Csehi, Bela Hegedus, Eva Mersich ne/ e Donat, Gyorgyi Szabonee Komlosi, Erika Horvath nee Sziki
  • Patent number: 5225416
    Abstract: The present invention relates to novel 1,2,3,6-tetrahydropyridine derivatives of the general formula (I) ##STR1## wherein R stands for hydrogen or an alkyl group,X stands for an unsubstituted phenyl or benzyl group or for a phenyl or benzyl group substituted with a halogen atom,Y stands for hydrogen or halogen or a trifluoro-methyl groupas well as enantiomers acid addition salts thereof.The invention further extends to pharmaceutical compositions containing said compounds as active ingredient mainly for improving cerebral blood circulation and antihypoxic activity.
    Type: Grant
    Filed: December 10, 1991
    Date of Patent: July 6, 1993
    Assignee: Richter Gedeon Vegyeszeti Termekek Gyara Rt.
    Inventors: Tibor Gizur, Kalman Harsanyi, Attila Csehi, Aniko Demeter nee Szabo, Ferenc Trischler, Eva Vajda, Laszlo Szporny, Bela Kiss, Egon Karpati, Eva Palosi, Zsolt Szombathelyi, Adam Sarkadi, Aniko Gere, Mihaly Bodo, Katalin Csomor, Judit Laszy, Zsolt Szentirmai, Erzsebet Lapis, Sandor Szabo
  • Patent number: 5169859
    Abstract: The present invention relates to novel compounds of the general formula (I) ##STR1## wherein R means hydrogen or C.sub.1-4 alkyl group; andY stands for cyano, trifluoromethyl, aryloxy or aryl(C.sub.1-4 alkyl)oxy group.The compounds according to the invention show a gastric acid secretion-inhibiting effect and therefore, they are useful for the treatment of gastric and duodenal ulcers. In addition, they exert a cytoprotective action against gastric laesions induced, e.g. by indomethacin or acid-containing alcohol.
    Type: Grant
    Filed: July 18, 1991
    Date of Patent: December 8, 1992
    Assignee: Richter Gedeon Vegyeszeti Gyar RT
    Inventors: Istvan Szabadkai, Kalman Harsanyi, Zsoltne Szabo, Bela Hegedus, Elemer Ezer, Judit Matuz, Laslo Szporny, Katalin Saghy, Gyorgy Hajos, Attila Csehi, Gabor Balogh
  • Patent number: 5162359
    Abstract: Novel antihyperlipoproteinemic compounds are disclosed of the formula I, ##STR1## wherein X is a halogen atom, methyl, ethyl, methoxy or ethoxy group,Y is hydroxy if X is methoxy or ethoxy, otherwise it is a hydrogen atom or a, methoxy or ethoxy group,Z is a methoxy or ethoxy group if X or Y is a methoxy group or an ethoxy group; otherwise it is hydrogen atom,The invention also covers antiartheriosclerotic, antihyperlipoproteinemic pharmaceutical compositions, suitable for inhibiting the formation of thrombuses, comprising the compounds of formula I in an effective dose, a process for preparing the same and methods for the treatment of hyperlipoproteinemia with the aid of the said compounds or compositions.
    Type: Grant
    Filed: September 3, 1991
    Date of Patent: November 10, 1992
    Assignee: Richter Gedeon Vegyeszeti Gyar Rt.
    Inventors: Kalman Harsanyi, Peter Tetenyi, Tamas Nagy, Attila Csehi, Tibor Gizur, Bela Hegedus, Andrea Maderspach, Andras Javor, Gyorgy Hajos, Laszlo Szporny