Patents by Inventor Attila Kis-Tamas
Attila Kis-Tamas has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 9487462Abstract: Compounds of general formula (I), salts or solvates thereof and pharmaceutical compositions containing same: wherein Z is N or CH or the Z(R1) part is replaced with a covalent bond, m and n is 0, 1, 2 or 3; HET is heteroaryl; X is CF3, halogen, CO-heterocyclyl, COOR3 or CONHR3; R1 is H, (CH2)o-aryl, (CH2)p-heteroaryl, (CH2)q-biphenyl; C(O)—R5; S(O)2—R6; R2 is H, aryl, heteroaryl, Y—(CH2)r-aryl, Y—(CH2)s-heteroaryl, where some of the above substituents may be substituted; Y is O or S; with the exclusion of the compound where HET is 1,3-thiazol, X is COOH, R1 is 4-fluorophenyl and R2 is benzyloxy. The invention also relates to the use of a compound of general formula (I), salts or solvates thereof for the use in the prevention or treatment of diseases where the activation of MMPs is involved in the pathomechanism. In this aspect the use of the above excluded compound is also inventive.Type: GrantFiled: December 19, 2011Date of Patent: November 8, 2016Assignees: PharmaHungary 2000 Kft., TargetEx Kft.Inventors: Péter Ferdinandy, Tamás Bálint Csont, Csaba Csonka, Krisztina Kedvesné Kupai, László Kovács, Attila Kis-Tamás, Ferenc Tamás Takács, Dénes Kónya, Gábor Medgyes, Sándor Cseh, István Hajdú, Zsolt Lörincz, György Dormán, Anikó Görbe
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Publication number: 20130303572Abstract: Compounds of general formula (I), salts or solvates thereof and pharmaceutical compositions containing same: wherein Z is N or CH or the Z(R1) part is replaced with a covalent bond, m and n is 0, 1, 2 or 3; HET is heteroaryl; X is CF3, halogen, CO-heterocyclyl, COOR3 or CONHR3; R1 is H, (CH2)o-aryl, (CH2)p-heteroaryl, (CH2)q-biphenyl; C(O)—R5; S(O)2—R6; R2 is H, aryl, heteroaryl, Y—(CH2)r-aryl, Y—(CH2)s-heteroaryl, where some of the above substituents may be substituted; Y is O or S; with the exclusion of the compound where HET is 1,3-thiazol, X is COOH, R1 is 4-fluorophenyl and R2 is benzyloxy. The invention also relates to the use of a compound of general formula (I), salts or solvates thereof for the use in the prevention or treatment of diseases where the activation of MMPs is involved in the pathomechanism. In this aspect the use of the above excluded compound is also inventive.Type: ApplicationFiled: December 19, 2011Publication date: November 14, 2013Inventors: Péter Ferdinandy, Tamás Bálint Csont, Csaba Csonka, Krisztina Kedvesné Kupai, László Kovács, Attila Kis-Tamás, Ferenc Tamás Takács, Dénes Kónya, Gábor Medgyes, Sándor Cseh, István Hajdú, Zsolt Lõrincz, György Dormán, Anikó Görbe
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Patent number: 6239286Abstract: Process for the preparation of compounds of formula (I) wherein R means hydrogen atom, or C1-6 alkyl group, or C7-12 aralkyl group or phenyl group, characterised in that: a) the compound of formula (III) is reacted with a compound of formula (IV) wherein X means halogen atom or C1-5 alkoxy group or hydroxyl group and the resulting compound of formula (II) is transformed in the presence of an oxidising agent in a reaction medium with pH above 7, into the compound of formula (I), or b) the compound of formula (III) is reacted with an anhydride of general formula (V) and the resulting compound of formula (II) transformed in the presence of an oxidising agent, in a reaction medium with pH above 7, into the compound of formula (I), or c) a compound of formula (II) is transformed in the presence of an oxidising agent, in a reaction medium with pH above 7, into the compound of formula (I), and if desired, the resulting compounds of formula (I), before or after isolation, are transformed into acid addition salts, orType: GrantFiled: May 15, 2000Date of Patent: May 29, 2001Assignee: Sanofi-SynthelaboInventors: Attila Kis-Tamás, Csaba Huszár, Bertrand Castro, Attila Németh, Péter Aranyosi, Károly Gyüre, István Mészáros, Ilona Dervalicsné Zrínyi, Katalin Dubovszki, Lajosné Páli, Antal Gajáry, Attila Supic, Zsuzsanna Nád, Zoltán Makovi, Endre Kollár, Zsuzsanna Csetriné Hári, Ágnes Kunsztné Kárász, Erzsébet Bognár
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Patent number: 6211382Abstract: Process for the preparation of compounds of formula (I) wherein R means hydrogen atom, or C1-6 alkyl group, or C7-12 aralkyl group or phenyl group, characterised in that a) the compound of formula (III) is reacted with a compound of formula (IV) wherein X means halogen atom or C1-5 alkoxy group or hydroxyl group, and the resulting compound of formula (II) is transformed, in a reaction medium with pH above 7, into the compound of formula (I) or b) the compound of formula (III) is reacted with an anhydride of general formula (V) and the resulting compound of formula (II) transformed, in a reaction medium with pH above 7, into the compound of formula (I), or c) a compound of formula (II) is transformed, in a reaction medium with pH above 7, into the compound of formula (I), and if desired, the resulting compounds of formula (I), before or after isolation, are transformed into acid addition salts, or the compounds of formula (I) are liberated from their acid addition salts.Type: GrantFiled: April 13, 2000Date of Patent: April 3, 2001Assignee: Sanofi-SynthelaboInventors: Csaba Huszár, Attila Kis-Tamás, Attila Németh, Zsuzsanna Nád, Zoltán Makovi, Antal Gajáry, Endre Kollár, Péter Aranyosi, Károly Gyüre, István Mészáros, Zsuzsanna Csetriné Hári, Attila Supic, Ilona Dervalicsne Zrinyi, Katalin Dubovszki, Lajosné Páli, Ágnes Kunsztné Kárász, Erzsébet Bognár
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Patent number: 6162923Abstract: The present invention relates to a process for the preparation of a compound of general formula (I), ##STR1## wherein R.sup.1 represents a hydrogen atom or an alkyl group of 1-6 carbon atoms, and their salts, wherein the compound of formula (II): ##STR2## is reacted with a compound of formula (III): ##STR3## wherein R represents an alkyl group of 1-4 carbon atoms and R.sup.1 is the same as defined above, by heating their neutral pH mixtures at the boiling temperature of the mixture, and the resulting compound of general formula (IV): ##STR4## wherein R and R.sup.1 are the same as defined above, is cyclized into the compound of general formula (I) by further elevating the temperature of the neutral mixture, and if desired, the compounds of general formula (I) are transformed into their salts, or the compounds of general formula (I) are liberated from their salts.Type: GrantFiled: April 26, 2000Date of Patent: December 19, 2000Assignee: Sanofi-SynthelaboInventors: Csaba Huszar, Attila Kis-Tamas, Attila Nemeth, Antal Gajary, Lajosne Pali
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Patent number: 4740228Abstract: The invention relates to new plant growth regulating compositions, which contain as active agent 0.001 to 95% by weight of one or more compound(s) of the general formula (I), ##STR1## wherein R.sup.1 and R.sup.2 each represent hydrogen atom, a C.sub.1-5 alkyl group, a C.sub.5-7 cycloalkyl group, an aryl group, a halogen-substituted aryl group, an aralkyl group, a C.sub.2-5 alkenyl group or a C.sub.2-5 alkynyl group, orR.sup.1 and R.sup.2 form, together with the adjacent nitrogen atom, a morpholino, pyrrolidino, piperidino or perhydroazepinyl group, andR.sup.3 stands for hydrogen or a C.sub.1-5 alkyl group,together with an inert, solid, liquid and/or gaseous carrier or diluent, and optionally one or more additives, such as surfactants or other substances of plant biological activity.The compounds of the general formula (I) in which R.sup.1 is hydrogen and R.sup.2 stands for hydrogen, C.sub.1-3 alkyl, aralkyl or C.sub.3-5 alkenyl group, furthermore in which R.sup.1 and R.sup.3 are hydrogen and R.sup.Type: GrantFiled: January 10, 1984Date of Patent: April 26, 1988Assignee: Egyt Gyogyszervegyeszeti GyarInventors: Attila Kis-Tamas, Ferenc Jurak, Zoltan Vig, Pal Fekete, Judit Kulcsar
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Patent number: 4588435Abstract: The invention relates to new N-substituted amino propane sulfonic acid derivatives of the Formula I ##STR1## and salts and hydrates thereof, a process for the preparation thereof and plant growth regulating agents comprising the same whereinR.sup.1 and R.sup.2 may be identical or different and stand for hydrogen, halogen, lower alkyl or lower alkoxy andR stands for furyl; or lower alkyl or phenyl the two latter groups being optionally substituted by one or more halogeno atom(s).Type: GrantFiled: January 31, 1985Date of Patent: May 13, 1986Assignee: EGYT Gyogyszervegyeszeti GyarInventors: Zoltan Budai, Attila Kis-Tamas, Aranka Lay nee Konya, Zoltan Vig, Viktor Andriska, Tibor Mezei
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Patent number: 4511737Abstract: The invention relates to new bicyclo(2.2.1)heptane derivatives of the general formula I ##STR1## wherein R represents a C.sub.1-12 alkyl group optionally substituted by a lower alkoxy group, a C.sub.2-4 alkenyl group or a phenyl-(lower alkyl) group optionally substituted on (I), phenyl ring by one or more lower alkoxy groups or halogen atoms.The invention relates further to plant growth regulating compositions comprising as active agent 0.001 to 95% by weight of a racemic and/or optically active compound of the general formula I, wherein R has the above defined meanings, along with a conventional organic or inorganic, solid and/or liquid carrier and/or filler and/or diluent and/or surfactant.Type: GrantFiled: November 15, 1983Date of Patent: April 16, 1985Assignee: EGYT Gyogyszervegyeszeti GyarInventors: Zoltan Budai, Attila Kis-Tamas, Tibor Mezei, Aranka Lay, Zoltan Vigh, Agnes Sokorai
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Patent number: 4469703Abstract: The invention relates to nitroalkanol derivatives of the general formula (I), ##STR1## wherein R.sub.1 is a C.sub.2-12 alkenyl or alkadienyl group, a C.sub.4-12 alkoxyalkyl or alkoxyalkenyl group having one or more C.sub.1-3 alkyl substituents, a C.sub.3-6 cycloalkyl or cycloalkenyl group, a furyl group, a nitrofuryl group, or a phenyl group having optionally one or more identical or different substituents selected from the group consisting of hydroxy, C.sub.1-4 alkoxy, halogen, nitro, C.sub.1-4 alkylenedioxy and C.sub.1-4 alkenoyloxy groups,R.sub.2 and R.sub.4 each represent hydrogen or they form together a valence bond,R.sub.3 is a C.sub.1-12 alkanoyloxy group, a benzoyloxy group having optionally one or more halogen substituents or hydrogen atom, andR.sub.5 is a C.sub.1-12 alkyl group or a phenyl group having optionally one or more halogen substituents,with the proviso that if R.sub.2 and R.sub.4 each stand for hydrogen, R.sub.1 is other than unsubstituted phenyl and R.sub.3 may represent only a C.sub.Type: GrantFiled: February 22, 1982Date of Patent: September 4, 1984Assignee: Egyt Gyogyszervegyeszeti GyarInventors: Attila Kis-Tamas, Gyula Mikite, Erzsebet Csutak nee Jakucs, Laszlo Kocsis
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Patent number: 4425158Abstract: The invention relates to new bicyclo(2.2.1)heptane derivatives of the general formula I ##STR1## wherein R represents a C.sub.1-12 alkyl group optionally substituted by a lower alkoxy group, a C.sub.2-4 alkenyl group or a phenyl-(lower alkyl) group optionally substituted on the phenyl ring by one or more lower alkoxy groups or halogen atoms.The invention relates further to plant growth regulating compositions comprising as active agent 0.001 to 95% by weight of a racemic and/or optically active compound of the general formula I, wherein R has the above defined meanings, along with a conventional organic or inorganic, solid and/or liquid carrier and/or filler and/or diluent and/or surfactant.Type: GrantFiled: November 18, 1981Date of Patent: January 10, 1984Assignee: EGYT Gyogyszervegyeszeti GyarInventors: Zoltan Budai, Attila Kis-Tamas, Tibor Mezei, Aranka Lay nee Konya, Zoltan Vigh, Agnes Sokorai nee Janki
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Patent number: 4364931Abstract: The invention relates to a composite insect attractant for male white-line dart moths [Scotia segetum] containing 7[Z]-dodecen-l-ol acetate of the formula [I] ##STR1## and 9[Z]-tetradecen-l-ol acetate of the formula [II] ##STR2## as active agents in a weight ratio of I to II of [50-99]:[50-1], optionally along with a liquid or solid adjuvant.Another object of the invention is an insect trap containing said composition and a process for attracting and trapping male white-line dart moths as well as a process for disrupting their mating by air permeation technique. The invention relates further to a novel process for the preparation of the active ingredients of the composition.Type: GrantFiled: December 24, 1980Date of Patent: December 21, 1982Assignee: Egyt Gyogyszervegyeszeti GyarInventors: Csaba Szantay, Lajos Novak, Miklos Toth, Jozsef Jakab, Attila Kis-Tamas, Istvan Ujvari
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Patent number: 4344959Abstract: The invention relates to new compounds of the general formula (I), ##STR1## wherein R.sup.1 is hydrogen or a lower alkoxy group andZ.sup.1 is hydrogen, orR.sup.1 and Z.sup.1 form together a double bond,Z.sup.2 is hydrogen andB is hydroxy, orZ.sup.2 and B form together a double bond,Z.sup.3 and Z.sup.4 each stand for hydrogen or they form together an ethylene group, orZ.sup.4 and D form together a double bond,C is oxygen atom or a lower alkoxy group,D is a valence bond if C stands for oxygen, or otherwise D forms a double bond together with Z.sup.4 or Z.sup.5,Z.sup.5 forms a double bond together with D or represents hydrogen, andR.sup.2 is a group of the general formula --COOR.sup.3, wherein R.sup.3 is lower alkyl, orZ.sup.5 and R.sup.2 form together a 1-oxo-2-oxa-tetramethylene group, with the proviso that if Z.sup.3 and Z.sup.4 form together an ethylene group, R.sup.2 may stand only for a --COOR.sup.3 group,insecticidal compositions containing them, as well as to a process for their preparation.Type: GrantFiled: April 6, 1981Date of Patent: August 17, 1982Assignee: Egyt Gyogyszervegyeszeti GyarInventors: Lajos Novak, Csaba Szantay, Janos Rohaly, Attila Kis-Tamas, Laszlo Varjas, Janos Csutak
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Patent number: 4310348Abstract: Racemic or optionally active 2-(propargyloxyimino)-1,7,7-trimethyl-bicyclo[2,2,1]heptane of the formula (I) ##STR1## or a mixture of these isomers is prepared by reacting a racemic or optically active 1,7,7-trimethyl-bicyclo[2,2,1]heptane derivative of the general formula (II), ##STR2## wherein Y stands for oxygen atom, sulfur atom or oxime group, with a propyne derivative of the general formula (III),R--CH.sub.2 --C.tbd.CH (III)whereinR stands for halogen atom or aminooxy group, with the proviso that if Y represents oxime group, R may stand only for halogen, and if R represents aminooxy group, Y may stand only for oxygen or sulfur atom.The resulting product is new and possesses strong plant growth promoting and insecticidal effects.This is a division of application Ser. No. 065,156, filed Aug. 9, 1979, now U.S. Pat. No. 4,244,888, Jan. 13, 1981.Type: GrantFiled: July 9, 1980Date of Patent: January 12, 1982Assignee: Egyt Gyogyszervegyeszeti GyarInventors: Zoltan Budai, Ferenc Jurak, Attila Kis-tamas, Aranka Lay nee Konya, Tibor Mezei, Zoltan Vig, Terez Zubovits nee Kristof
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Patent number: 4244888Abstract: Racemic or optically active 2-(propargyloxyimino)-1,7,7-trimethyl-bicyclo[2,2,1]heptane of the formula (I) ##STR1## or a mixture of these isomers is prepared by reacting a racemic or optically active 1,7,7-trimethyl-bicyclo[2,2,1]heptane derivative of the general formula (II), ##STR2## wherein Y stands for oxygen atom, sulfur atom or oxime group, with a propyne derivative of the general formula (III),R--CH.sub.2 --C.tbd.CH (III)whereinR stands for halogen atom or aminooxy group, with the proviso that if Y represents oxime group, R may stand only for halogen, and if R represents aminooxy group, Y may stand only for oxygen or sulfur atom.The resulting product is new and possesses strong plant growth promoting and insecticidal effects.Type: GrantFiled: August 9, 1979Date of Patent: January 13, 1981Assignee: Egyt Gyogyszervegyeszeti GyarInventors: Zoltan Budai, Ferenc Jurak, Attila Kis-Tamas, Aranka Lay nee Konya, Tibor Mezei, Zoltan Vig, Terez Zubovits nee Kristof
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Patent number: 4243660Abstract: The invention relates to a composite insect attractant for male cabbage moths (Mamestra brassicae) containing (Z)-11-hexadecenyl acetate and (Z)-11-heptadecenyl acetate as active agents in a weight ratio of 70 to 90:80 to 1, optionally along with a liquid or solid adjuvant. An insect trap can contain the composition which is used for attracting and trapping cabbage moth. Their mating is disrupted by air permeation techniques. (Z)-11-heptadecenyl acetate is a synergistically active new compound. The composition according to the invention produces a significantly stronger stimulating reaction on male cabbage moths than the known sex lure compositions.Type: GrantFiled: April 19, 1979Date of Patent: January 6, 1981Assignee: Egyt Gyogyszervegyeszeti GyarInventors: Csaba Szantay, Lajos Novak, Miklos Toth, Jozsef Balla, Bela Stefko, Attila Kis-Tamas
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Patent number: 4160035Abstract: A plant protecting composition with pesticidal effects contains an effective amount of at least one compound of the formula ##STR1## wherein R is a C.sub.1-20 alkyl group or a phenyl or phenyl-C.sub.1-3 alkylene group having optionally one or more C.sub.1-3 alkyl or halogen substituents on the phenyl ring, and a diluent in an amount necessary to make up the final weight of the composition. To kill plant pests, the composition is applied to growing plants either prior to or after emergence.Type: GrantFiled: November 3, 1977Date of Patent: July 3, 1979Assignee: Egyt Gyogyszervegyeszeti GyarInventors: Laszlo Levai, Gyula Mikite, Attila Kis-Tamas