Abstract: The present invention provides compounds of formula (I) and/or salts thereof and/or biologically active metabolites thereof and/or prodrugs thereof and/or solvates thereof and/or hydrates thereof and/or polymorphs thereof having affinity and selectivity for the gamma-aminobutyric acid A receptor subunit alpha 5 and act as GABAA ?5 positive allosteric modulators, thereby useful in the treatment or prevention of diseases related to the GABAA ?5 receptor, process for the preparation and intermediates of the preparation process thereof, pharmaceutical compositions comprising them alone or in combination with one or more other active ingredients and their use as medicaments.

Abstract: The present invention provides fungal proteases and improved fungal strains that are deficient in protease production.

Abstract: The present invention provides fungal proteases and improved fungal strains that are deficient in protease production.

Abstract: The present invention provides fungal proteases and improved fungal strains that are deficient in protease production.

Abstract: The present invention provides fungal proteases and improved fungal strains that are deficient in protease production.

Abstract: A system for handling slides having a tray moving on a carriage with seats for the slides and with a tray moving mechanism, a slide loading arm, and a slide holding frame having a slide loading arm driving motor. There are outstretched Maltese crosses on the lower side of the tray of the slide feeder and a crank is arranged in the carriage, opposite to and parallel with the crosses. The slide loading arm is arranged movably and tiltably above and a supporting plate is arranged movably and tiltably below the slide holder. The slide holding frame has a lifting means for tilting the slide loading arm and the supporting plate. The lifting means is actuated by a controller arranged on the disk of the crank.

Abstract: The present invention provides fungal proteases and improved fungal strains that are deficient in protease production.

Abstract: The invention relates to a system for handling slides comprising a tray moving on a carriage provided with seats for the slides and with a tray moving mechanism; a slide loading arm; and a slide holding frame provided with a slide loading arm driving motor, wherein the slide holder (30) is provided with slide holding elements; there are outstretched Maltese crosses (13) on the lower side of the tray (6 ) of the slide feeder (1) and a crank (14) is arranged in the carriage (4), opposite to and parallel with the crosses (13), said crank being coupled to said crosses; said slide loading arm (9) is arranged movably and tillable above (30) and a supporting plate (11) is arranged movably and tiltable below the slide holder, said supporting plate cooperating with said slide loading arm. The slide holding frame (7) is provided with lifting means for tilting the slide loading arm (9) and the supporting plate (11), said lifting means being actuated by controlling means arranged on the disk (15) of the crank (14).

Abstract: A focusing method is provided for the high speed digitalization of microscope slides using an imaging device, wherein the slide is divided into fields of view according to the imaging device and focusing is performed. During rough focusing, several images are captured within the focus range using large focus steps. On the basis of this set of images the position of the best contrast is determined. Fine focusing is performed by adjusting the focus according to the focus distance already determined for another field of view and by focusing with fine steps. A slide displacing device is provided, which enables the displacement of a slide parallel to the optical axis. The slide displacing device includes slide holding elements affixed to one side of a supporting member having two parallel sides, which are connected by stiffening elements defining at least two parallel planes.

Abstract: A method for the storage ensuring fast retrieval and efficient transfer of interrelated, high volume, mainly 3D, information, whereby the input information is assigned to two files, so that image data information required for histological reconstruction is stored in one file and information regarding predetermined parameters of the image data is stored in the other file, whereas in the course of the storing of the received information, associated information regarding the hierarchical relationship of individual image data is also stored in a further file. A computer program product for the storage ensuring fast retrieval and efficient transfer of interrelated, high-volume, mainly 3D, information, contains a computer-readable storage medium including a computer-readable programme code, further a software tool to store associated information regarding the hierarchical relationship of individual image data, while storing input information.

Abstract: A focusing method is provided for the high speed digitalization of microscope slides using an imaging device, wherein the slide is divided into fields of view according to the imaging device and focusing is performed. During rough focusing, several images are captured within the focus range using large focus steps. On the basis of this set of images the position of the best contrast is determined. Fine focusing is performed by adjusting the focus according to the focus distance already determined for another field of view and by focusing with fine steps. A slide displacing device is provided, which enables the displacement of a slide parallel to the optical axis. The slide displacing device includes slide holding elements affixed to one side of a supporting member having two parallel sides, which are connected by stiffening elements defining at least two parallel planes.

Abstract: A slide feeding unit for a microscope includes a slide magazine having a base plate; a toothed rack secured to a magazine side wall; and slide guiding elements perpendicular to an open magazine side. The unit further includes a magazine moving mechanism having a magazine-receiving trough including opposite side plates. Two rotary shafts supported by the trough extend along the trough side plates. Magazine-advancing feeding gears are supported by the side plates and may mesh with the toothed magazine rack. Lifting gears, held in the side plates, have pins on which the magazine is supported when raised or lowered. Driving worm gears are rotated by the shafts and mesh with the lifting gears. The unit also includes a slide feeding device having a robot arm displaceable perpendicularly to the direction of advance of the magazine for removing a slide from the magazine.

Abstract: A slide feeding unit for a microscope includes a slide magazine having a base plate; a toothed rack secured to a magazine side wall; and slide guiding elements perpendicular to an open magazine side. The unit further includes a magazine moving mechanism having a magazine-receiving trough including opposite side plates. Two rotary shafts supported by the trough extend along the trough side plates. Magazine-advancing feeding gears are supported by the side plates and may mesh with the toothed magazine rack. Lifting gears, held in the side plates, have pins on which the magazine is supported when raised or lowered. Driving worm gears are rotated by the shafts and mesh with the feeding gears and the lifting gears. The unit also includes a slide feeding device having a robot arm displaceable perpendicularly to the direction of advance of the magazine for removing a slide from the magazine.