Patents by Inventor Attila Lorincz

Attila Lorincz has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • CANCER MARKERS
    Publication number: 20180179597
    Abstract: Hence, the invention relates to a method for diagnosis and/or prognosis of cancer, comprising the steps of analyzing in a sample of a subject the DNA methylation status of a genomic region of at least one member of the group of, (i) SFN according to SEQ ID NO. 1, (ii) SLIT2 according to SEQ ID NO. 2, (iii) SERPINB5 according to SEQ ID NO. 3; and (iv) TWIST 1 according to SEQ ID NO 4; wherein, if (i) SFN shows a methylation cut-off value of above 80% and/or, (ii) SLIT2 shows a methylation cut-off value of above 45% and/or, (iii) SERPBINB5 shows a methylation cut-off value of above 70%, and/or (iv) TWIST 1 shows a methylation level below 15% the sample is categorized as a sample from a patient with cancer and/of a poor prognosis.
    Type: Application
    Filed: February 14, 2018
    Publication date: June 28, 2018
    Inventor: Attila Lorincz
  • Method for determining prognosis of prostate cancer in a subject
    Patent number: 9845506
    Abstract: A method for determining the prognosis of prostate cancer in a subject is provided which comprises the assessment of the methylation status of the HSPB1 gene in a prostate cancer sample.
    Type: Grant
    Filed: March 19, 2013
    Date of Patent: December 19, 2017
    Assignee: Queen Mary University of London
    Inventors: Attila Lorincz, Natasa Vasiljevic, Amar Ahmad
  • Individually synthesized primers to be used in whole genome amplification
    Patent number: 9593366
    Abstract: Disclosed are compositions and methods for random amplification of nucleic acid sequences of interest using random-G-deficient primers. Also disclosed are methods of randomly amplifying a target nucleic acid sequence using random G-deficient primers alone or in combination with random, partially random, or specific primers.
    Type: Grant
    Filed: October 26, 2009
    Date of Patent: March 14, 2017
    Assignee: QIAGEN GAITHERSBURG, INC.
    Inventors: Irina Nazarenko, Dominic O'Neil, Ha Thai, Attila Lorincz
  • Detection of nucleic acids by target-specific hybrid capture method
    Patent number: 9115410
    Abstract: Target-specific hybrid capture (TSHC) provides a nucleic acid detection method that is not only rapid and sensitive, but is also highly specific and capable of discriminating highly homologous nucleic acid target sequences. The method produces DNA:RNA hybrids which can be detected by a variety of methods.
    Type: Grant
    Filed: March 15, 2013
    Date of Patent: August 25, 2015
    Assignee: QIAGEN GAITHERSBURG, INC.
    Inventors: Irina Nazarenko, Attila Lorincz, Paul Eder, Brian Lowe, Richard Mallonee, Ha Thai
  • METHOD FOR DETERMINING PROGNOSIS OF PROSTATE CANCER IN A SUBJECT
    Publication number: 20150051084
    Abstract: A method for determining the prognosis of prostate cancer in a subject is provided which comprises the assessment of the methylation status of the HSPB1 gene in a prostate cancer sample.
    Type: Application
    Filed: March 19, 2013
    Publication date: February 19, 2015
    Inventors: Attila Lorincz, Natasa Vasiljevic, Amar Ahmad
  • Detection of nucleic acids by target-specific hybrid capture method
    Patent number: 8901287
    Abstract: Target-specific hybrid capture (TSHC) provides a nucleic acid detection method that is not only rapid and sensitive, but is also highly specific and capable of discriminating highly homologous nucleic acid target sequences. The method produces DNA:RNA hybrids which can be detected by a variety of methods.
    Type: Grant
    Filed: October 9, 2009
    Date of Patent: December 2, 2014
    Assignee: Qiagen Gaithersburg, Inc.
    Inventors: Irina Nazarenko, Attila Lorincz, Paul Eder, Brian Lowe, Richard Mallonee, Ha Thai
  • CANCER MARKERS
    Publication number: 20140051587
    Abstract: Hence, the invention relates to a method for diagnosis and/or prognosis of cancer, comprising the steps of analyzing in a sample of a subject the DNA methylation status of a genomic region of at least one member of the group of, (i) SFN according to SEQ ID NO. 1, (ii) SLIT2 according to SEQ ID NO. 2, (iii) SERPINB5 according to SEQ ID NO. 3; and (iv) TWIST 1 according to SEQ ID NO 4; wherein, if (i) SFN shows a methylation cut off value of above 80% and/or, (ii) SLIT2 shows a methylation cut-off value of above 45% and/or, (iii) SERPBINB5 shows a methylation cut-off value of above 70%, and/or (iv) TWIST 1 shows a methylation level below 15% the sample is categorized as a sample from a patient with cancer and/of a poor prognosis.
    Type: Application
    Filed: March 30, 2012
    Publication date: February 20, 2014
    Applicant: QUEEN MARY AND WESTFIELD COLLEGE UNIVERSITY OF LONDON
    Inventor: Attila Lorincz
  • Detection of nucleic acids by target-specific hybrid capture method
    Patent number: 8557973
    Abstract: Target-specific hybrid capture (TSHC) provides a nucleic acid detection method that is not only rapid and sensitive, but is also highly specific and capable of discriminating highly homologous nucleic acid target sequences. The method produces DNA-RNA hybrids which can be detected by a variety of methods.
    Type: Grant
    Filed: October 14, 2010
    Date of Patent: October 15, 2013
    Assignee: Qiagen Gaithersburg, Inc.
    Inventors: James Anthony, Attila Lorincz, John Troy, Yanglin Tan
  • Detection of nucleic acids by type-specific hybrid capture method
    Patent number: 8389219
    Abstract: Target-specific hybrid capture (TSHC) provides a nucleic acid detection method that is not only rapid and sensitive, but also highly specific and capable of discriminating highly homologous nucleic acid sequences. The method produces DNA/RNA hybrids which can be detected by a variety of methods.
    Type: Grant
    Filed: November 19, 2009
    Date of Patent: March 5, 2013
    Assignee: Qiagen Gaithersburg, Inc.
    Inventors: James Anthony, Attila Lorincz, Inna Williams, John Troy, Yanlin Tang
  • INDIVIDUALLY SYNTHESIZED PRIMERS TO BE USED IN WHOLE GENOME AMPLIFICATION
    Publication number: 20110256591
    Abstract: Disclosed are compositions and methods for random amplification of nucleic acid sequences of interest using random-G-deficient primers. Also disclosed are methods of randomly amplifying a target nucleic acid sequence using random G-deficient primers alone or in combination with random, partially random, or specific primers.
    Type: Application
    Filed: October 26, 2009
    Publication date: October 20, 2011
    Inventors: Irina Nazarenko, Dominic O'Neil, Ha Thai, Attila Lorincz
  • DETECTION OF NUCLEIC ACIDS BY TARGET-SPECIFIC HYBRID CAPTURE METHOD
    Publication number: 20110059542
    Abstract: Target-specific hybrid capture (TSHC) provides a nucleic acid detection method that is not only rapid and sensitive, but is also highly specific and capable of discriminating highly homologous nucleic acid target sequences. The method produces DNA-RNA hybrids which can be detected by a variety of methods.
    Type: Application
    Filed: October 14, 2010
    Publication date: March 10, 2011
    Applicant: QIAGEN GAITHERSBURG INC.
    Inventors: James Anthony, Attila Lorincz, John Troy, Yanglin Tan
  • Detection of nucleic acids by type specific hybrid capture method
    Patent number: 7829691
    Abstract: Target-specific hybrid capture (TSHC) provides a nucleic acid detection method that is not only rapid and sensitive, but is also highly specific and capable of discriminating highly homologous nucleic acid target sequences. The method produces DNA-RNA hybrids which can be detected by a variety of methods.
    Type: Grant
    Filed: October 19, 2008
    Date of Patent: November 9, 2010
    Assignee: Qiagen Gaithersburg, Inc.
    Inventors: James Anthony, Attila Lorincz, John Troy, Yanglin Tan
  • DETECTION OF NUCLEIC ACIDS BY TARGET-SPECIFIC HYBRID CAPTURE METHOD
    Publication number: 20100036104
    Abstract: Target-specific hybrid capture (TSHC) provides a nucleic acid detection method that is not only rapid and sensitive, but is also highly specific and capable of discriminating highly homologous nucleic acid target sequences. The method produces DNA:RNA hybrids which can be detected by a variety of methods.
    Type: Application
    Filed: October 9, 2009
    Publication date: February 11, 2010
    Applicant: QIAGEN GAITHERSBURG INC.
    Inventors: Irina Nazarenko, Attila Lorincz, Paul Eder, Brian Lowe, Richard Mallonee, Ha Thai
  • Detection of nucleic acids by type-specific hybrid capture method
    Patent number: 7645571
    Abstract: Target-specific hybrid capture (TSHC) provides a nucleic acid detection method that is not only rapid and sensitive, but is also highly specific and capable of discriminating highly homologous nucleic acid target sequences. The method produces DNA/RNA hybrids which can be detected by a variety of methods.
    Type: Grant
    Filed: June 15, 2001
    Date of Patent: January 12, 2010
    Assignee: Qiagen Gaithersburg, Inc.
    Inventors: James Anthony, Attila Lorincz, Inna Williams, John Troy, Yanlin Tang
  • Detection of nucleic acids by target-specific hybrid capture method
    Patent number: 7601497
    Abstract: Target-specific hybrid capture (TSHC) provides a nucleic acid detection method that is not only rapid and sensitive, but is also highly specific and capable of discriminating highly homologous nucleic acid target sequences. The method produces DNA:RNA hybrids which can be detected by a variety of methods.
    Type: Grant
    Filed: November 7, 2005
    Date of Patent: October 13, 2009
    Assignee: Qiagen Gaithersburg, Inc.
    Inventors: Irina Nazarenko, Attila Lorincz, Paul Eder, Brian Lowe, Richard Mallonee, Ha Thai
  • DETECTION OF NUCLEIC ACIDS BY TYPE SPECIFIC HYBRID CAPTURE METHOD
    Publication number: 20090162851
    Abstract: Target-specific hybrid capture (TSHC) provides a nucleic acid detection method that is not only rapid and sensitive, but is also highly specific and capable of discriminating highly homologous nucleic acid target sequences. The method produces DNA-RNA hybrids which can be detected by a variety of methods.
    Type: Application
    Filed: October 19, 2008
    Publication date: June 25, 2009
    Applicant: DIGENE CORPORATION
    Inventors: JAMES ANTHONY, ATTILA LORINCZ, JOHN TROY, YANGLIN TAN
  • Detection of nucleic acids by type-specific hybrid capture method
    Patent number: 7439016
    Abstract: Target-specific hybrid capture (TSHC) provides a nucleic acid detection method that is not only rapid and sensitive, but is also highly specific and capable of discriminating highly homologous nucleic acid target sequences. The method produces DNA-RNA hybrids which can be detected by a variety of methods.
    Type: Grant
    Filed: June 15, 2000
    Date of Patent: October 21, 2008
    Assignee: Digene Corporation
    Inventors: James Anthony, Attila Lorincz, John Troy, Yanglin Tan
  • Novel approach to molecular diagnosis of human papillomavirus-related diseases
    Publication number: 20070243552
    Abstract: The present invention relates to an accurate, sensitive, and efficient sequential or concurrently sequential method for molecular diagnosis of human papillomavirus (HPV)-based disease, where the method improves the accuracy and reliability of diagnostic and prognostic assessments of HPV-based disease. The method of the invention comprises a primary screen of a sample for HPV nucleic acids, followed by a secondary screen for molecular markers, such as proliferation and cell cycle control group protein markers. The sequential or concurrently sequential method significantly reduces the number of false positive results.
    Type: Application
    Filed: May 24, 2007
    Publication date: October 18, 2007
    Inventors: Inna Williams, Attila Lorincz, Aisling O'Hara
  • ASSESSMENT OF HUMAN PAPILLOMA VIRUS-RELATED DISEASE
    Publication number: 20070154884
    Abstract: This invention provides novel methods for assessing HPV infection. Gene expression levels are used to assess the progression of HPV infection from benign to malignant growth. Also provided are kits for carrying out the methods of this invention.
    Type: Application
    Filed: March 2, 2007
    Publication date: July 5, 2007
    Inventors: Attila Lorincz, James Lazar
  • Detection of nucleic acids by target-specific hybrid capture method
    Publication number: 20060051809
    Abstract: Target-specific hybrid capture (TSHC) provides a nucleic acid detection method that is not only rapid and sensitive, but is also highly specific and capable of discriminating highly homologous nucleic acid target sequences. The method produces DNA:RNA hybrids which can be detected by a variety of methods.
    Type: Application
    Filed: November 7, 2005
    Publication date: March 9, 2006
    Inventors: Irina Nazarenko, Attila Lorincz, Paul Eder, Brian Lowe, Richard Mallonee, Ha Thai