Abstract: A method of controlling a temperature of a biopharmaceutical product during blow-fill sealing, includes developing a model based on heat transfer mechanisms that incorporates the effects of the blow-fill sealing on the biopharmaceutical product, providing a parison to a blow-fill sealing machine for accepting the biopharmaceutical product during the blow-fill sealing, predicting a temperature of at least one the biopharmaceutical product, the parison, and a component of the blow-fill sealing machine at a stage in the blow-fill sealing, and adjusting a parameter of the blow-fill sealing machine to reduce damage to the biopharmaceutical product.

Abstract: Disclosed are proteolysis-targeting chimeric molecules (PROTACs) that induce degradation of c-MYC protein. The disclosed PROTACs typically include a first targeting moiety that binds to c-MYC (Mc-MYC) which may be derived from a substituted heterocycle that binds to c-MYC such as a substituted pyrazole. The first targeting moiety typically is linked via a bond or a linker (L) to a second targeting moiety that binds to an E3 ubiquitin ligase (ME3). As such, the disclosed PROTACS may be described as having a formula Mc-MYC-L-ME3 or ME3-L-Mc-MYC.

Abstract: Disclosed are substituted heterocycle compounds including substituted pyrazoles, substituted pyrimidines, and substitute triazoles. The substituted heterocycles disclosed herein are shown to be useful in inhibiting c-MYC and may be utilized as therapeutics for treating cancer and cell proliferative disorders.

Abstract: Disclosed are substituted heterocycle compounds including substituted pyrazoles, substituted pyrimidines, and substitute triazoles. The substituted heterocycles disclosed herein are shown to be useful in inhibiting c-MYC and may be utilized as therapeutics for treating cancer and cell proliferative disorders.

Abstract: Disclosed are proteolysis-targeting chimeric molecules (PROTACs) that induce degradation of c-MYC protein. The disclosed PROTACs typically include a first targeting moiety that binds to c-MYC (Mc-MYC) which may be derived from a substituted heterocycle that binds to c-MYC such as a substituted pyrazole. The first targeting moiety typically is linked via a bond or a linker (L) to a second targeting moiety that binds to an E3 ubiquitin ligase (ME3). As such, the disclosed PROTACS may be described as having a formula Mc-MYC-L-ME3 or ME3-L-Mc-MYC.

Abstract: Systems, methods, and apparatus for transmitting and receiving signals are disclosed. In one or more embodiments, the disclosed method involves splitting a signal into low power portions. The method further involves coding the low power portions to produce coded low power portions, where the coding comprises convolving each low power portion with a respective different code. Also, the method involves summing the coded low power portions to produce a resultant coded signal. In addition, the method involves transmitting the resultant coded signal towards a target object. Additionally, the method involves receiving a reflected resultant coded signal, where the resultant coded signal reflects off the target object to produce the reflected resultant coded signal. Also, the method involves decoding the reflected resultant coded signal to produce a decoded signal. Further, the method involves correlating the decoded signal to produce a complete received signal.

Abstract: A fluid dispensing device includes a dispensing cylinder, a first inlet and a second inlet. The first inlet is disposed within a first container on which the fluid dispensing device is mounted. The first inlet and the second inlet are configured to facilitate intake of only one fluid into the dispensing cylinder at a given point in time. The fluid dispensing device also includes a first outlet and a second outlet. The first outlet and the second outlet are configured to dispense only one fluid out of the dispensing cylinder at a given point in time. The fluid dispensing device further includes a valve assembly fluidically coupled to the first inlet and the second inlet, and to the first outlet and the second outlet. The valve assembly is configured to control flow of the fluids within and/or out of the dispensing cylinder.

Abstract: Systems, methods, and apparatus for transmitting and receiving signals are disclosed. In one or more embodiments, the disclosed method involves splitting a signal into low power portions. The method further involves coding the low power portions to produce coded low power portions, where the coding comprises convolving each low power portion with a respective different code. Also, the method involves summing the coded low power portions to produce a resultant coded signal. In addition, the method involves transmitting the resultant coded signal towards a target object. Additionally, the method involves receiving a reflected resultant coded signal, where the resultant coded signal reflects off the target object to produce the reflected resultant coded signal. Also, the method involves decoding the reflected resultant coded signal to produce a decoded signal. Further, the method involves correlating the decoded signal to produce a complete received signal.

Abstract: A fluid dispensing device is provided. The fluid dispensing device includes a dispensing cylinder and a first inlet and a second inlet configured to facilitate intake of one of or more fluids into the dispensing cylinder. The first inlet is disposed within a first container on which the fluid dispensing device is mounted. The first inlet and the second inlet are configured to facilitate intake of only one fluid into the dispensing cylinder at a given point in time. The fluid dispensing device also includes a first outlet and a second outlet configured to dispense the one or more fluids. The first outlet and the second outlet are configured to dispense only one fluid out of the dispensing cylinder at a given point in time. The fluid dispensing device further includes a valve assembly fluidically coupled to the first inlet and the second inlet, and to the first outlet and the second outlet. The valve assembly is configured to control flow of the fluids within and/or out of the dispensing cylinder.

Abstract: A particular method includes splitting a signal into multiple portions corresponding to elements of an array. The method also includes coding and phase adjusting the multiple portions of the signal to form phase adjusted, coded portions of the signal by coding each portion of the multiple portions with a different code and by applying phase adjustments associated with the corresponding elements of the array to the portions. The method also includes transmitting the phase adjusted, coded portions of the signal via the corresponding elements of the array.

Abstract: A system and method for pricing software service requests is provided. The method includes entering input details corresponding to a clients' software service usage data. The method further includes calculating a cost per ticket for each severity level of the software service request. A margin for each severity level is assigned to each severity level in the order of increasing severity. Thereafter, a price per software service request is calculated for each severity level using the corresponding margin. Additionally, the method includes determining an optimal staffing scheme corresponding to one or more software services.

Abstract: Systems and methods according to one or more embodiments provide for a multicode transmitter/receiver that acts like a high power array when a correlated receiver is used, but acts as a collection of small low gain transmitters when an uncorrelated receiver is used. In one embodiment, a method of transmitting and receiving signals comprises splitting a signal into more than one portion for feeding the signal into separate elements of an array; coding each portion of the signal for transmission through each separate element of the array with a different code respectively; transmitting each coded portion of the signal through a corresponding separate element of the array; receiving the coded portions of the signal by at least one element on a receiver side; decoding the coded portions of the signal; and adding decoded portions of the signal to form a complete received signal.

Abstract: A method, system and computer program product for efficiently quantifying the economic impact of retiming flights without the necessity of implementing the traditional airline forecasting system from scratch. A forecast module computes the difference in impact prior to and after the retiming of a flight. A flight grouping module, using the computed difference in impact, generates a new schedule, which is used by the forecast module to generate new changes in impact, until the schedule converges. A flyable module generates a list of retimed flights based on the converged schedule for resolving operational infeasibilities of the latter. The forecast module generates a profit for each of the retimed flights, which is used by a scheduling module to improve the schedule, which is used by the forecast module to revise the economic impacts for the list of all retimed flights. This process continues until no further economic improvement can be made.

Abstract: Systems and methods according to one or more embodiments provide for a multicode transmitter/receiver that acts like a high power array when a correlated receiver is used, but acts as a collection of small low gain transmitters when an uncorrelated receiver is used. In one embodiment, a method of transmitting and receiving signals comprises splitting a signal into more than one portion for feeding the signal into separate elements of an array; coding each portion of the signal for transmission through each separate element of the array with a different code respectively; transmitting each coded portion of the signal through a corresponding separate element of the array; receiving the coded portions of the signal by at least one element on a receiver side; decoding the coded portions of the signal; and adding decoded portions of the signal to form a complete received signal.

Abstract: A system and method for pricing software service requests is provided. The method includes entering input details corresponding to a clients' software service usage data. The method further includes calculating a cost per ticket for each severity level of the software service request. A margin for each severity level is assigned to each severity level in the order of increasing severity. Thereafter, a price per software service request is calculated for each severity level using the corresponding margin. Additionally, the method includes determining an optimal staffing scheme corresponding to one or more software services.

Abstract: A method, system and computer program product for efficiently quantifying the economic impact of retiming flights without the necessity of implementing the traditional airline forecasting system from scratch. A forecast module computes the difference in impact prior to and after the retiming of a flight. A flight grouping module, using the computed difference in impact, generates a new schedule, which is used by the forecast module to generate new changes in impact, until the schedule converges. A flyable module generates a list of retimed flights based on the converged schedule for resolving operational infeasibilities of the latter. The forecast module generates a profit for each of the retimed flights, which is used by a scheduling module to improve the schedule, which is used by the forecast module to revise the economic impacts for the list of all retimed flights. This process continues until no further economic improvement can be made.

Abstract: The present invention is a system and method for allowing an administrator of a computer network higher up in a hierarchical arrangement to define the scope of policies for the services offered, and users lower in the hierarchical arrangement to customize policies within the scope defined by the administrator. While defining policy rules, administrators classify them as scoping or non-scoping. Users lower in the hierarchical arrangement can then customize scoping rules by defining sub-rules. Policy rules have a condition part and an action part, and the sub-rules can be used to change the scope of the condition and action parts. The present invention adds all the non-scoping policy rules, all the scoping policy rules, and all the sub-rules (with their scope limited by the scoping rules) to a rules database. This rules database is then used by any policy enforcement engine to enforce policy rules.

Abstract: A circuit and method for reducing the power consumed by module-based scan testing. In one embodiment constant data is provided to inputs, such as 33, of scan chains not used in testing, such as 32. Another embodiment is a method whereby transitions in a subset of scan chains, such as 32, are minimized through the use of constant input data.

Abstract: A timing closure analysis associated with SoCs uses voltage drop based standard delay formats (SDFs). Static timing analysis (STA) is implemented using multiple SDFs, one for each mode (ATPG Test, BIST Test, Functional) as contrasted with doing STA with only one worst-case SDF for all modes. The multiple SDFs account for the impact of dynamic voltage drops on delays in addition to static IR drops.

Abstract: The present invention provides a system, method and computer program product for managing customers in a hierarchical manner. The customer hierarchy comprises a root service provider (RSP), tiered service providers (TSPs) and end customers. The present invention enables the governing of the customers by a large service provider by providing an ability to make smaller service providers as customers and managing their resources. The smaller service provider, in turn, can have its own customers. The smaller service provider governs these customers without interference from the service providers above it in the hierarchy. The customers are governed by policies. A policy is a set of rules laid down by the service provider to control the customers. The present invention also enables the service provider to implement different policies on different customers and change the policy for a customer without affecting other customers.