Patents by Inventor Atul K. Tandon

Atul K. Tandon has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Enhancement of immunochemical staining in aldehyde-fixed tissues
    Patent number: 5578452
    Abstract: A method for restoring immunoreactivity of a tissue, particularly decalcified tissue, fixed width an aldehyde fixative agent and embedded in an embedding medium, usually comprising celloidin, the method comprising the steps of contacting the tissue with an aldehyde releasing reagent solution comprising a solvent and an aldehyde releasing reagent and removing aldehyde released by the aldehyde releasing reagent from contact with the tissue by reacting the aldehyde in a substantially irreversible manner to form a non-aldehyde derivative, and removing excess base from the tissue. A preferred solution for celloidin-embedded decalcified tissue comprises methanolic sodium hydroxide at about one-third saturation.
    Type: Grant
    Filed: April 7, 1994
    Date of Patent: November 26, 1996
    Assignee: Biogenex Laboratories
    Inventors: Shan-Rong Shi, Atul K. Tandon, Krishan L. Kalra, Nagesh Malhotra, Sheng-Hui Su, Cheng-Zhi Yu
  • Heat shock/stress response proteins and prognosis in cancer
    Patent number: 5447843
    Abstract: The invention relates to a method of predicting disease-free survival in cancer patients by relating the number and amount of stress response proteins in cancer tissue to the probability of tumor recurrence. Particular heat shock/stress response proteins useful in the determination of tumor recurrence are the stress response proteins, hsp70, hsp90, hsp27, and glucose regulated protein grp94. Specific levels of the stress response proteins relative to an internal standard are identified, above which the probability of tumor recurrence is highly significant. Kit methods are disclosed which could enable determination of the stress proteins by an antibody assay.
    Type: Grant
    Filed: November 25, 1992
    Date of Patent: September 5, 1995
    Assignee: Board of Regents, The University of Texas System
    Inventors: William L. McGuire, deceased, Gary M. Clark, Gary C. Chamness, Atul K. Tandon, Suzanne A. Fuqua
  • Method and kit for the prognostication of breast cancer patient via heat shock/stress protein determination
    Patent number: 5188964
    Abstract: The invention relates to a method of predicting disease-free survival in cancer patients by relating the number and amount of stress response proteins in the cancer tissue to the probability of tumor recurrence. Particular heat shock/stress response proteins useful in the determination of tumor recurrence are the stress response proteins, hsp70, hsp90, hsp27, and glucose regulated protein grp94. Specific levels of the stress response proteins are identified, above which the probability of tumor recurrence is highly signficant. Kit methods are disclosed which could enable determination of the stress proteins by an antibody assay.
    Type: Grant
    Filed: April 12, 1990
    Date of Patent: February 23, 1993
    Assignee: Board of Regents, The University of Texas System
    Inventors: William L. McGuire, Atul K. Tandon, Gary M. Clark, Gary C. Chamness
  • Enhancement of immunochemical staining in aldehyde-fixed tissue
    Patent number: RE40835
    Abstract: A method for restoring immunoreactivity of a tissue, particularly decalcified tissue, fixed width an aldehyde fixative agent and embedded in an embedding medium, usually comprising celloidin, the method comprising the steps of contacting the tissue with an aldehyde releasing reagent solution comprising a solvent and an aldehyde releasing reagent and removing aldehyde released by the aldehyde releasing reagent from contact with the tissue by reacting the aldehyde in a substantially irreversible manner to form a non-aldehyde derivative, and removing excess base from the tissue. A preferred solution for celloidin-embedded decalcified tissue comprises methanolic sodium hydroxide at about one-third saturation.
    Type: Grant
    Filed: August 12, 1993
    Date of Patent: July 7, 2009
    Assignee: BioGenx Laboratories, Inc.
    Inventors: Shan-Rong Shi, Atul K. Tandon, Krishan L. Kalra, Nagesh Malhotra, Sheng-Hui Su, Cheng-Zhi Yu