Abstract: The present invention provides a two-component drug delivery system for intravenous administration of an aqueous and sterile acetylsalicylic acid composition comprising: a first and second component which are physically separated, wherein the first component comprises a therapeutically effective amount of an acetylsalicylic acid; wherein the second component has a pH of 5.0 to 11.0 comprising an aqueous buffer solution; and providing a buffered aqueous solution of acetylsalicylic acid with a pH of 6.0-8.0 upon mixing, wherein said first component comprises a sterile spray dried or a sterile 20-90 kGy gamma irradiated, or an autoclaved terminally sterilized acetyl salicylic acid particulate powder; with the proviso that arginine, lysine, glutamic acid and betaine are excluded. The invention also provides drug delivery devices comprising the two-component drug delivery system, use of the system and devices in acetyl salicylic acid treatment of patients in need thereof and methods of manufacturing.

Abstract: A fan unit a nozzle assembly including a plurality of nozzles configured to receive an air flow and to expel the air flow through a plurality of outlets corresponding to the plurality of nozzles. A controller configured to control a longitudinal movement of a nozzle of the plurality of nozzles based on an operating condition associated with the fan unit.

Abstract: The invention involves novel, oral solutions of bitter drugs using Vitamin E TPGS as a masking agent and methods of using the same (e.g., for treating attention deficit/hyperactivity disorder (ADHD)). Atomoxetine (e.g., Atomoxetine HCl) is an example of a bitter drug whose bitterness can be masked by the presence of Vitamin E TPGS alone or in combination with additional ingredients.

Abstract: The invention relates to a novel metolazone lyophilizate composition and a pharmaceutically acceptable diluent that can be used to reconstitute the metolazone lyophilizate for parenteral administration. The invention also relates to a novel metolazone pre-lyophilizate composition as well as uses of the reconstituted metolazone lyophilizate.

Abstract: Systems and methods for implementing a command stack for an application are disclosed and an embodiment includes receiving an input for executing a first command of the application, initiating execution of the first command, executing one or more second commands which are set to execute based on execution of the first command, completing execution of the first command, and including the first command in the command stack such that an association is defined between the first command and the one or more second commands. In one embodiment, defining the association in the command stack between the first command the one or more second commands may include generating a first nested command stack associated with the first command, including the one or more second commands in the first nested command stack, and including the first command and the first nested command stack in the command stack.

Abstract: In a blockchain network, a “cold wallet” allows users to securely create and store their private key and sign their transaction data only when the wallet is completely offline. When a user requests a transaction, a user key tag that identifies the user's key is determined. The transaction data and the user's key tag are transmitted to a cold wallet that includes an HSM Trusted Client and an HSM over a first one-way communication channel during a window in a first sequence of connection windows. Inside the cold wallet, the HSM Trusted Client uses the user key tag to determine an encrypted version of the user's signing key. During a processing window, the transaction data and encrypted signing key are transmitted to the HSM, where a cleartext key is recovered and used to sign the transaction, and the signed transaction is transmitted back to the HSM Trusted Client. During a second connection window, the signed transaction is transmitted from the HSM Trusted Client for transmission to the blockchain network.

Abstract: An air-gapped system enables the secure transfer and control of digital assets, such as those associated with crypto-currency. The system includes an Integration Server for receiving requests from an application interface, a Central Control Center for verifying the requests received and authorizing the requests using digital signatures, and multiple Distributed Data Centers, each including a cold Data Center Hardware Security Module (DC HSM). These DC HSMs securely store and manage cryptographic keys. Each Data Center also includes an offline Processing Unit coupling its DC HSM to a dedicated Remote Controlled Server. The Remote Controlled Server receives requests from the Integration Server and forwards them to the Processing Unit of a DC HSM using a Near-Field Communication (NFC) Interface between the two. Preferably, the NFC interface is physically shielded to resist side channel attacks.

Abstract: Systems and methods for implementing a command stack for an application are disclosed and an embodiment includes receiving an input for executing a first command of the application, initiating execution of the first command, executing one or more second commands which are set to execute based on execution of the first command, completing execution of the first command, and including the first command in the command stack such that an association is defined between the first command and the one or more second commands. In one embodiment, defining the association in the command stack between the first command the one or more second commands may include generating a first nested command stack associated with the first command, including the one or more second commands in the first nested command stack, and including the first command and the first nested command stack in the command stack.

Abstract: Systems and methods for implementing a command stack for an application are disclosed and an embodiment includes receiving an input for executing a first command of the application, initiating execution of the first command, executing one or more second commands which are set to execute based on execution of the first command, completing execution of the first command, and including the first command in the command stack such that an association is defined between the first command and the one or more second commands. In one embodiment, defining the association in the command stack between the first command the one or more second commands may include generating a first nested command stack associated with the first command, including the one or more second commands in the first nested command stack, and including the first command and the first nested command stack in the command stack.

Abstract: Systems and methods for implementing a command stack for an application are disclosed and an embodiment includes receiving an input for executing a first command of the application, initiating execution of the first command, executing one or more second commands which are set to execute based on execution of the first command, completing execution of the first command, and including the first command in the command stack such that an association is defined between the first command and the one or more second commands. In one embodiment, defining the association in the command stack between the first command the one or more second commands may include generating a first nested command stack associated with the first command, including the one or more second commands in the first nested command stack, and including the first command and the first nested command stack in the command stack.

Abstract: An air-gapped system enables the secure transfer and control of digital assets, such as those associated with crypto-currency. The system includes an Integration Server for receiving requests from an application interface, a Central Control Center for verifying the requests received and authorizing the requests using digital signatures, and multiple Distributed Data Centers, each including a cold Data Center Hardware Security Module (DC HSM). These DC HSMs securely store and manage cryptographic keys. Each Data Center also includes an offline Processing Unit coupling its DC HSM to a dedicated Remote Controlled Server. The Remote Controlled Server receives requests from the Integration Server and forwards them to the Processing Unit of a DC HSM using a Near-Field Communication (NFC) Interface between the two. Preferably, the NFC interface is physically shielded to resist side channel attacks.

Abstract: The present invention relates to a composition comprising caspofungin or a pharmaceutical acceptable salt thereof and succinate or lactate as a buffering agent.

Abstract: The present invention provides solid oral pharmaceutical compositions comprising combination of metformin and sitagliptin or salts thereof. In particular, the present invention relates to a multilayered coated pharmaceutical composition comprising at least two compartments of metformin or salts thereof exhibiting immediate and extended release and at least one compartment of sitagliptin and metformin or salts thereof exhibiting immediate release. The invention also includes process of preparing such compositions and method of use of such compositions for treating type II diabetes.

Abstract: The present invention provides solid oral pharmaceutical compositions comprising combination of metformin and sitagliptin or salts thereof. In particular, the present invention relates to a pharmaceutical composition comprising metformin and sitagliptin or salts thereof which is glidant and/or surface active agent. The invention also includes process of preparing such compositions and method of use of such compositions for treating type II diabetes.

Abstract: The present invention relates to a composition comprising caspofungin or a pharmaceutical acceptable salt thereof and succinate or lactate as a buffering agent.

Abstract: Provided are controlled release pharmaceutical compositions comprising desvenlafaxine oxalate, one or more release rate controlling polymers, and pharmaceutically acceptable excipients.

Abstract: The present invention relates to a composition comprising caspofungin or a pharmaceutical acceptable salt thereof and succinate or lactate as a buffering agent.

Abstract: Dosage forms of oxcarbazepine or a pharmaceutically acceptable salt thereof and a pH modifying agent for use in oral administration are provided.