Patents by Inventor Aubrey R. Tiernan

Aubrey R. Tiernan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Cell culture methods involving HDAC inhibitors or rep proteins
    Patent number: 11898170
    Abstract: The invention relates to methods of culturing cells, generating cell lines, and delivering polynucleotides to cells involving the use of HDAC inhibitors and/or adeno-associated virus (AAV) rep proteins.
    Type: Grant
    Filed: March 22, 2018
    Date of Patent: February 13, 2024
    Assignee: Ultragenyx Pharmaceutical Inc.
    Inventors: Aubrey R. Tiernan, Christopher Tipper
  • ENGINEERED PRODUCER CELL LINES AND METHODS OF MAKING AND USING THE SAME
    Publication number: 20200325455
    Abstract: This application relates to recombinant adeno-associated virus (rAAV) packaging and/or producer cell lines which have been engineered to reduce expression and/or activity of one or more genes and/or proteins to increase rAAV titers. The methods of generating the engineered cell lines have also been described herein.
    Type: Application
    Filed: April 9, 2020
    Publication date: October 15, 2020
    Inventors: Aubrey R. Tiernan, Nicholas Richards
  • CELL CULTURE METHODS INVOLVING HDAC INHIBITORS OR REP PROTEINS
    Publication number: 20200032221
    Abstract: The invention relates to methods of culturing cells, generating cell lines, and delivering polynucleotides to cells involving the use of HDAC inhibitors and/or adeno-associated virus (AAV) rep proteins.
    Type: Application
    Filed: March 22, 2018
    Publication date: January 30, 2020
    Inventors: Aubrey R. Tiernan, Christopher Tipper