Patents by Inventor Aude CHAPUIS

Aude CHAPUIS has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • HIGH AFFINITY MAGE-A1-SPECIFIC TCRS AND USES THEREOF
    Publication number: 20210355189
    Abstract: The present disclosure provides TCRs with high or enhanced affinity against various tumor associated antigens (including human MAGE-A1 epitopes), T cells expressing such high affinity antigen-specific TCRs, nucleic acids encoding the same, and compositions for use in treating diseases or disorders in which cells overexpress one or more of these antigens, such as in cancer.
    Type: Application
    Filed: December 22, 2020
    Publication date: November 18, 2021
    Inventors: Aude CHAPUIS, Thomas SCHMITT, Megan MCAFEE
  • MERKEL CELL POLYOMAVIRUS T ANTIGEN-SPECIFIC TCRS AND USES THEREOF
    Publication number: 20210252057
    Abstract: The present disclosure provides binding proteins and TCRs with high affinity and specificity against Merkel cell polyomavirus T antigen epitopes or peptides, T cells expressing such high affinity Merkel cell polyomavirus T antigen specific TCRs, nucleic acids encoding the same, and compositions for use in treating Merkel cell carcinoma.
    Type: Application
    Filed: May 15, 2019
    Publication date: August 19, 2021
    Inventors: Aude CHAPUIS, Paul NGHIEM, Megan MCAFEE, Natalie MILLER, Kelly PAULSON, David KOELLE, Thomas SCHMITT, Candice CHURCH
  • High affinity MAGE-A1-specific TCRs and uses thereof
    Patent number: 11034748
    Abstract: The present disclosure provides TCRs with high or enhanced affinity against various tumor associated antigens (including human MAGE-A1 epitopes), T cells expressing such high affinity antigen-specific TCRs, nucleic acids encoding the same, and compositions for use in treating diseases or disorders in which cells overexpress one or more of these antigens, such as in cancer.
    Type: Grant
    Filed: September 13, 2019
    Date of Patent: June 15, 2021
    Assignee: FRED HUTCHINSON CANCER RESEARCH CENTER
    Inventors: Aude Chapuis, Thomas Schmitt, Megan McAfee
  • HIGH AFFINITY MAGE-A1-SPECIFIC TCRS AND USES THEREOF
    Publication number: 20200017568
    Abstract: The present disclosure provides TCRs with high or enhanced affinity against various tumor associated antigens (including human MAGE-A1 epitopes), T cells expressing such high affinity antigen-specific TCRs, nucleic acids encoding the same, and compositions for use in treating diseases or disorders in which cells overexpress one or more of these antigens, such as in cancer.
    Type: Application
    Filed: September 13, 2019
    Publication date: January 16, 2020
    Inventors: Aude CHAPUIS, Thomas SCHMITT, Megan MCAFEE