Patents by Inventor Audrey Bernstein

Audrey Bernstein has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • USP10 TARGETED SELF-DELIVERABLE SIRNA COMPOSITIONS AND METHODS FOR PREVENTING OR INHIBITING FIBROSIS AND/OR SCARRING
    Publication number: 20230122801
    Abstract: The present disclosure provides compositions and methods for using self-deliverable siRNA (sdRNAi) directed against USP-10 for the treatment of various medical conditions, including skin scarring due to trauma wounds and surgery, corneal and retina scarring due to injury and surgery, internal organ scarring due to injury and surgery, heart tissue scarring due to heart attack and surgery, and lung, liver, and kidney fibrosis due to inflammation and injury. In embodiments, compositions including self-deliverable siRNA (sdRNAi) directed against USP-10 are suitable for use in pharmaceutical formulations and treatments resulting in significant less scar formation, and include synthetic nucleic acids such as sense and antisense oligonucleotides.
    Type: Application
    Filed: February 28, 2021
    Publication date: April 20, 2023
    Inventors: Audrey Bernstein, Alexey Wolfson, Sean McCauley
  • RNAi inhibition of USP10 to treat ocular disorders
    Patent number: 9714424
    Abstract: Reduction of ocular scarring is accomplished from the discovery that silencing of the expression of USP10 in the area of a wound under healing will reduce the accumulation of integrin on the cell's surface and activation of the fibrotic growth factor TGF?, thereby preventing ocular scarring.
    Type: Grant
    Filed: December 15, 2015
    Date of Patent: July 25, 2017
    Assignee: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
    Inventors: Audrey Bernstein, Stephanie Gillespie