Patents by Inventor Audrey P. Gasch

Audrey P. Gasch has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Over-expression of AZF1 improves the rate of anaerobic xylose fermentation in engineered yeast strains
    Patent number: 11591376
    Abstract: The present invention provides an isolated AZF1 gene sequence, recombinant vectors, and recombinant yeast which are useful in methods of enhanced biofuel production, particularly ethanol production. Methods of bioengineering recombinant yeast with isolated AZF1 gene sequence useful for biofuel production are also provided.
    Type: Grant
    Filed: October 10, 2018
    Date of Patent: February 28, 2023
    Assignee: Wisconsin Alumni Research Foundation (WARF)
    Inventors: Audrey P. Gasch, Kevin Myers
  • Engineered yeast strains enabling anaerobic xylose fermentation decoupled from microbial growth
    Patent number: 11326174
    Abstract: The present invention relates to materials and methods for the production of ethanol. More particularly, the present invention provides genetically modified strains of Saccharomyces cerevisiae exhibiting decreased level of BCY1 protein activity and capable of anaerobic fermentation of xylose into ethanol without the need for cell growth. Also provided are methods of using such genetically engineered yeast strains for improved anaerobic xylose fermentation in the yeast for industrial-scale production of various fuels, chemical feedstocks, and synthetic polymers.
    Type: Grant
    Filed: August 16, 2019
    Date of Patent: May 10, 2022
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Kevin S Myers, Audrey P Gasch
  • ENGINEERED YEAST STRAINS ENABLING ANAEROBIC XYLOSE FERMENTATION DECOUPLED FROM MICROBIAL GROWTH
    Publication number: 20200056194
    Abstract: The present invention relates to materials and methods for the production of ethanol. More particularly, the present invention provides genetically modified strains of Saccharomyces cerevisiae exhibiting decreased level of BCY1 protein activity and capable of anaerobic fermentation of xylose into ethanol without the need for cell growth. Also provided are methods of using such genetically engineered yeast strains for improved anaerobic xylose fermentation in the yeast for industrial-scale production of various fuels, chemical feedstocks, and synthetic polymers.
    Type: Application
    Filed: August 16, 2019
    Publication date: February 20, 2020
    Inventors: Kevin S Myers, Audrey P Gasch
  • Genes that improve tolerance to lignocellulosic toxins when overexpressed in yeast
    Patent number: 10443062
    Abstract: The present invention provides isolated gene sequences useful in increasing lignocellulosic toxin tolerance in yeast. Such engineered yeast are useful in methods of biofuel production, particularly ethanol production. Methods of bioengineering recombinant yeast with increased lignocellulosic toxin tolerance are also provided.
    Type: Grant
    Filed: September 1, 2017
    Date of Patent: October 15, 2019
    Assignee: WISCONSIN ALUMNI RESEARCH FOUNDATION
    Inventors: Maria Sardi, Audrey P. Gasch
  • Over-Expression of AZF1 Improves the Rate of Anaerobic Xylose Fermentation in Engineered Yeast Strains
    Publication number: 20190106469
    Abstract: The present invention provides an isolated AZF1 gene sequence, recombinant vectors, and recombinant yeast which are useful in methods of enhanced biofuel production, particularly ethanol production. Methods of bioengineering recombinant yeast with isolated AZF1 gene sequence useful for biofuel production are also provided.
    Type: Application
    Filed: October 10, 2018
    Publication date: April 11, 2019
    Inventors: Audrey P. Gasch, Kevin Myers
  • GENES THAT IMPROVE TOLERANCE TO LIGNOCELLULOSIC TOXINS WHEN OVEREXPRESSED IN YEAST AND METHODS OF USE IN BIOFUEL PRODUCTION
    Publication number: 20180073033
    Abstract: The present invention provides isolated gene sequences useful in increasing lignocellulosic toxin tolerance in yeast. Such engineered yeast are useful in methods of biofuel production, particularly ethanol production. Methods of bioengineering recombinant yeast with increased lignocellulosic toxin tolerance are also provided.
    Type: Application
    Filed: September 1, 2017
    Publication date: March 15, 2018
    Inventors: Maria Sardi, Audrey P. Gasch
  • Genes related to xylose fermentation and methods of using same for enhanced biofuel production
    Patent number: 9506088
    Abstract: The present invention provides isolated gene sequences involved in xylose fermentation and related recombinant yeast which are useful in methods of enhanced biofuel production, particularly ethanol production. Methods of bioengineering recombinant yeast useful for biofuel production are also provided.
    Type: Grant
    Filed: August 19, 2015
    Date of Patent: November 29, 2016
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Dana J. Wohlbach, Audrey P. Gasch
  • Genes Related to Xylose Fermentation and Methods of Using Same for Enhanced Biofuel Production
    Publication number: 20160076059
    Abstract: The present invention provides isolated gene sequences involved in xylose fermentation and related recombinant yeast which are useful in methods of enhanced biofuel production, particularly ethanol production. Methods of bioengineering recombinant yeast useful for biofuel production are also provided.
    Type: Application
    Filed: August 19, 2015
    Publication date: March 17, 2016
    Inventors: Dana J. Wohlbach, Audrey P. Gasch
  • Genes related to xylose fermentation and methods of using same for enhanced biofuel production
    Patent number: 9145567
    Abstract: The present invention provides isolated gene sequences involved in xylose fermentation and related recombinant yeast which are useful in methods of enhanced biofuel production, particularly ethanol production. Methods of bioengineering recombinant yeast useful for biofuel production are also provided.
    Type: Grant
    Filed: June 17, 2014
    Date of Patent: September 29, 2015
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Dana J. Wohlbach, Audrey P. Gasch
  • Genes Related to Xylose Fermentation and Methods of Using Same for Enhanced Biofuel Production
    Publication number: 20150104841
    Abstract: The present invention provides isolated gene sequences involved in xylose fermentation and related recombinant yeast which are useful in methods of enhanced biofuel production, particularly ethanol production. Methods of bioengineering recombinant yeast useful for biofuel production are also provided.
    Type: Application
    Filed: June 17, 2014
    Publication date: April 16, 2015
    Inventors: Dana J. Wohlbach, Audrey P. Gasch
  • Genes related to xylose fermentation and methods of using same for enhanced biofuel production
    Patent number: 8795996
    Abstract: The present invention provides isolated gene sequences involved in xylose fermentation and related recombinant yeast which are useful in methods of enhanced biofuel production, particularly ethanol production. Methods of bioengineering recombinant yeast useful for biofuel production are also provided.
    Type: Grant
    Filed: April 6, 2012
    Date of Patent: August 5, 2014
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Dana J. Wohlbach, Audrey P. Gasch
  • GENES RELATED TO XYLOSE FERMENTATION AND METHODS OF USING SAME FOR ENHANCED BIOFUEL PRODUCTION
    Publication number: 20120258511
    Abstract: The present invention provides isolated gene sequences involved in xylose fermentation and related recombinant yeast which are useful in methods of enhanced biofuel production, particularly ethanol production. Methods of bioengineering recombinant yeast useful for biofuel production are also provided.
    Type: Application
    Filed: April 6, 2012
    Publication date: October 11, 2012
    Applicant: Wisconsin Alumni Research Foundation
    Inventors: Dana J. Wohlbach, Audrey P. Gasch
  • Recombinant yeast with improved ethanol tolerance and related methods of use
    Patent number: 8178331
    Abstract: The present invention provides isolated Elo1 and Mig3 nucleic acid sequences capable of conferring increased ethanol tolerance on recombinant yeast and methods of using same in biofuel production, particularly ethanol production. Methods of bioengineering yeast using the Elo1 and, or, Mig3 nucleic acid sequences are also provided.
    Type: Grant
    Filed: September 14, 2011
    Date of Patent: May 15, 2012
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Audrey P. Gasch, Jeffrey A. Lewis
  • RECOMBINANT YEAST WITH IMPROVED ETHANOL TOLERANCE AND RELATED METHODS OF USE
    Publication number: 20120064591
    Abstract: The present invention provides isolated Elo1 and Mig3 nucleic acid sequences capable of conferring increased ethanol tolerance on recombinant yeast and methods of using same in biofuel production, particularly ethanol production. Methods of bioengineering yeast using the Elo1 and, or, Mig3 nucleic acid sequences are also provided.
    Type: Application
    Filed: September 14, 2011
    Publication date: March 15, 2012
    Applicant: Wisconsin Alumni Research Foundation
    Inventors: Audrey P. Gasch, Jeffrey A. Lewis