Patents by Inventor August A. Ebeling

August A. Ebeling has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Preparation of pharmaceutical grade hemoglobins by heat treatment in partially oxygenated form
    Patent number: 5741894
    Abstract: During the purification of pharmaceutical grade crosslinked hemoglobin mixtures of crosslinked and uncrosslinked hemoglobin are heated in the presence of nonstoichiometric amounts of oxygen, resulting in the selective precipitation of the uncrosslinked hemoglobin. After separation of the precipitated uncrosslinked tetramers, the crosslinked hemoglobin remaining in the supernatant is so purified that a further chromatography purification step is unnecessary. This hemoglobin is highly crosslinked absolutely free of chromatography fines, and has a low methemoglobin content.
    Type: Grant
    Filed: September 22, 1995
    Date of Patent: April 21, 1998
    Assignee: Baxter International, Inc.
    Inventors: Mahmood Rezazadeh Azari, August A. Ebeling, John E. Picken, Timothy N. Estep