Patents by Inventor August Verbruggen

August Verbruggen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • GDF15 as a differential marker for spondyloarthropathy
    Patent number: 9086419
    Abstract: In vitro methods for differential diagnosis of spondyloarthropathy are disclosed which involve determining the levels of GDF15 in biological samples.
    Type: Grant
    Filed: February 17, 2010
    Date of Patent: July 21, 2015
    Assignee: Universiteit Gent
    Inventors: Stijn Lambrecht, Dieter Deforce, Dirk Elewaut, August Verbruggen
  • Scoring system to monitor natural or drug-modified disease progression in “erosive osteoarthritis” of the interphalangeal finger joints
    Patent number: 8532362
    Abstract: The present invention provides a scoring system to monitor natural or drug-modified disease progression in erosive inter-phalangeal finger joint osteoarthrits and the use of said scoring system to identify and value drugs with anticatabolic and/or repair promoting potential.
    Type: Grant
    Filed: July 24, 2009
    Date of Patent: September 10, 2013
    Assignee: Ghent University
    Inventors: August Verbruggen, Ruth Wittoek, Bert Vander Cruyssen, Dirk Elewaut
  • GDF15 AS A DIFFERENTIAL MARKER FOR SPONDYLOARTHROPATHY
    Publication number: 20110300562
    Abstract: In vitro methods for differential diagnosis of spondyloarthropathy are disclosed which involve determining the levels of GDF15 in biological samples.
    Type: Application
    Filed: February 17, 2010
    Publication date: December 8, 2011
    Applicant: UNIVERSITEIT GENT
    Inventors: Stijn Lambrecht, Dieter Deforce, Dirk Elewaut, August Verbruggen
  • SCORING SYSTEM TO MONITOR NATURAL OR DRUG-MODIFIED DISEASE PROGRESSION IN "EROSIVE OSTEOARTHRITIS" OF THE INTERPHALANGEAL FINGER JOINTS
    Publication number: 20110263948
    Abstract: The present invention provides a scoring system to monitor natural or drug-modified disease progression in erosive inter-phalangeal finger joint osteoarthrits and the use of said scoring system to identify and value drugs with anticatabolic and/or repair promoting potential.
    Type: Application
    Filed: July 24, 2009
    Publication date: October 27, 2011
    Applicant: GHENT UNIVERSITY
    Inventors: August Verbruggen, Ruth Wittoek, Bert Vander Cruyssen, Dirk Elewaut
  • Use of polysulphated alginate in cellular matrices
    Patent number: 7988962
    Abstract: The present invention describes an in vitro/ex vivo method for the cultivation of connective tissue cells or progenitor cells (e.g. chondrogenic cells) in matrix comprising polysulphated alginate. These cultivated cells can be used in the preparation of a medicament for the treatment or prevention of osteochondral defects. The invention also describes a matrix comprising polysulphated alginate and mammalian connective tissue cells or progenitor cells thereof.
    Type: Grant
    Filed: December 2, 2004
    Date of Patent: August 2, 2011
    Assignee: Universiteit Gent
    Inventors: August Verbruggen, Eric Veys
  • MARKERS OF MATRIX GENE EXPRESSION AND CELLULAR DIFFERENTIATION IN CHONDROCYTES
    Publication number: 20100330036
    Abstract: The invention relates generally to the field of tissue engineering. More particularly, the present invention relates to methods for identifying a population of cells suitable for the repair of connective tissue, including cartilage. The invention further provides methods and compositions related to the generation of a population of cells suitable for the repair of cartilage, in particular in the repair of cartilage degeneration associated with osteoarthritis. Methods of using said cells thus identified or thus generated, in methods to extend the period of cell manipulation, i.e. to increase the yield of cells suitable in the aforementioned methods, are also provided by the present invention.
    Type: Application
    Filed: October 20, 2008
    Publication date: December 30, 2010
    Applicant: UNIVERSITEIT GENT
    Inventors: Stijn Lambrecht, Dieter Deforce, Dirk Elewaut, August Verbruggen
  • Use of polysulphated alginate in cellular matrices
    Publication number: 20070128173
    Abstract: The present invention describes an in vitro/ex vivo method for the cultivation of connective tissue cells or progenitor cells (e.g. chondrogenic cells) in matrix comprising polysulphated alginate. These cultivated cells can be used in the preparation of a medicament for the treatment or prevention of osteochondral defects. The invention also describes a matrix comprising polysulphated alginate and mammalian connective tissue cells or progenitor cells thereof.
    Type: Application
    Filed: December 2, 2004
    Publication date: June 7, 2007
    Inventors: August Verbruggen, Eric Veys